Rchr
J-GLOBAL ID：200901092273831045
Update date: Mar. 20, 2024
Hosoya Akihiro
ホソヤ アキヒロ | Hosoya Akihiro
Affiliation and department：
Homepage URL (1)：
http://www3.hoku-iryo-u.ac.jp/courses/2/019/index.html
Research field (2)：
Oral medicine
, Anatomy
Research keywords (4)：
歯髄幹細胞
, 象牙質再生
, 象牙芽細胞
, Pulp calcification
Research theme for competitive and other funds (39)：
- 2022 - 2026 癌の骨破壊病変に対するHedgehogシグナルの分子基盤の構築と新たな治療戦略
- 2022 - 2025 株化歯根膜幹細胞の樹立と骨芽細胞分化メカニズムの解明
- 2022 - 2025 歯髄-象牙質の治癒・再生過程におけるCD146陽性幹細胞の局在と分化機序の解明
- 2021 - 2024 歯髄の創傷治癒・再生過程におけるGli1陽性幹細胞の動態と分化誘導機構の解明
- 2020 - 2023 Shh-Gli1応答性歯根膜幹細胞分化機構の解明と歯槽骨再生への応用
- 2020 - 2023 In vivo機能解析による唾液腺の代償性機能亢進機構の解明と分泌亢進誘導
- 2020 - 2023 Identification of novel dental pulp stem cells and analysis of their regulatory mechanisms of differentiation
- 2019 - 2022 Osteoblast differentiation of periodontal ligament stem cells expressing Gli1/Tomato fluorescence
- 2018 - 2021 Elucidation of odontoblast differentiation factors by fate mapping analysis and its application to dentin regeneration therapy
- 2017 - 2020 Tissue-resident macrophages in dental pulp regulate the microenvironment for reparative dentine formation
- 2017 - 2020 Analysis of reparative dentin formation regulated by dental pulp stem cells using a fate mapping approach
- 2016 - 2020 A study on the mechanisms of induction and differentiation of stem cells during wound healing and regeneration of dentin-pulp complex
- 2016 - 2019 Elucidation of the mechanism of bone-resorption in osteoclasts regulated by Pkn3.
- 2016 - 2019 Roles Gli1-positive dental pulp stem cells during dentin regeneration
- 2015 - 2018 Functional roles of the cancer stem cell marker EpCAM in cancer bone metastasis
- 2015 - 2017 Role of M2 macrophages in reparative dentin formation and development of new endodontic regerative treatment
- 2014 - 2017 The study of the mandibular condyle regeneration using the cell sheet
- 2014 - 2016 How is the formation site of osteoclasts determined?
- 2012 - 2015 The effect of SUMOylation on bone formation in mouse
- 2012 - 2015 Functional analysis of Osterix in immature odontoblasts for cell differentiation
- 2013 - 2014 骨代謝共役を担うWntシグナルの解明
- 2011 - 2013 The mechanisms of bone-selective cancer metastases based on the pre-metastatic bone niche hypothesis
- 2011 - 2012 We elucidated osteogenic capacity of CD90-posidive cells and side population (SP) cells derived from bone marrow stromal cells to establish the hard tissue regeneration therapy. Most of bone marrow stromal cells expressed CD90, one of mesenchymal stem cell markers, and contained 0.5% SP cells. CD90-positive cells and SP cells could differentiate osteoblastic cells in in vitro and in vivo. However, we could not clarify specific genes of osteoprogenitor cells.
- 2009 - 2012 Roles of cancer stem cells in the development and progression of cancer metastasis to bone
- 2010 - 2011 Dentin regeneration by Thy-1-positive dental pulp cells
- 2009 - 2010 歯根膜組織幹細胞の誘導と再生歯科医療の可能性
- 2008 - 2010 Analysis of molecular mechanism of carbon nanotube regulating bone metabolism
- 2008 - 2009 造血幹細胞ニッチを介した癌の骨転移成立機構の解明
- 2008 - 2009 An analysis of odontoblast differentiation mechanisms by using dental pulp SP cells
- 2006 - 2008 A study on mechanisms of tissue repair and regeneration of the dentin-pulp complex
- 2006 - 2007 The relationship between cell proliferation and RANKL-induced osteoclastogenesis
- 2006 - 2007 ヒト造血系細胞再構成マウスを用いた歯槽骨リモデリング機構の解析
- 2005 - 2006 BMP antagonist調節による歯および骨の再生
- 2005 - 2006 摘出歯髄を用いた硬組織形成機構の解明
- 2004 - 2005 Ca^<2+> kinetics in mature osteoclast
- 2004 - 2005 A study on mechanisms of tissue formation and regeneration of the dentin-pulp complex
- 2004 - 2005 再生骨および歯と受容者(recipient)組織間の特異的相互作用の解析
- 2003 - 2004 The establishment of inducible osteocyte ablation mouse model to elucidate the mechanisms of maxillo-mandibular dysmorphia.
- 2002 - 2004 Analysis of molecular mechanisms in bone formation and regeneration
Show all
Papers (95)：
-
Yuri Seki, Hiroaki Takebe, Yuya Nakao, Kohei Sato, Toshihide Mizoguchi, Hiroaki Nakamura, Masahiro Iijima, Akihiro Hosoya. Osteoblast differentiation of Gli1+ cells via Wnt and BMP signaling pathways during orthodontic tooth movement. Journal of oral biosciences. 2024
-
Karnoon Shamsoon, Daichi Hiraki, Koki Yoshida, Kiyofumi Takabatake, Hiroaki Takebe, Kenji Yokozeki, Naohiro Horie, Naomasa Fujita, Nisrina Ekayani Nasrun, Tatsuo Okui, et al. The Role of Hedgehog Signaling in the Melanoma Tumor Bone Microenvironment. International journal of molecular sciences. 2023. 24. 10
-
Saki Fujii, Hiroaki Takebe, Toshihide Mizoguchi, Hiroaki Nakamura, Tsuyoshi Shimo, Akihiro Hosoya. Bone formation ability of Gli1+ cells in the periodontal ligament after tooth extraction. Bone. 2023. 116786-116786
-
Toru Shibui, Akihiro Hosoya, Hiroaki Takebe, Masami Takahashi, Yuri Seki, Saki Fujii, Kazuharu Irie. Immunohistochemical localization of CD146 and alpha-smooth muscle actin during dentin formation and regeneration. Anatomical record (Hoboken, N.J. : 2007). 2023
-
Yuri Seki, Hiroaki Takebe, Toshihide Mizoguchi, Hiroaki Nakamura, Masahiro Iijima, Kazuharu Irie, Akihiro Hosoya. Differentiation ability of Gli1+ cells during orthodontic tooth movement. Bone. 2022. 116609-116609
ｍore...
MISC (71)：
-
Nazmus Shalehin. Three-dimensional morphological analysis of Dens invaginatus using micro CT. 2020. 39. 1. 11-15
-
吉羽永子, 大倉直人, 前川知樹, 泉健次, 細矢明宏, 中村浩彰, 前田健康, 野杁由一郎, 吉羽邦彦. ヒト歯髄においてシュワン細胞はマクロファージをM2型へ転換する. Journal of Oral Biosciences Supplement (Web). 2019. 2019
-
吉羽 永子, 大倉 直人, 細矢 明宏, 中村 浩彰, 野杁 由一郎, 吉羽 邦彦, 枝並 直樹, 遠間 愛子, 竹内 亮介. ヒト歯髄組織創傷治癒過程における骨髄由来間葉系前駆細胞fibrocyteの動態検索. Journal of Oral Biosciences Supplement. 2017. 2017. 427-427
-
吉羽永子, 大倉直人, 細矢明宏, 中村浩彰, 野杁由一郎, 吉羽邦彦. ヒト歯髄組織創傷治癒過程における骨髄由来間葉系前駆細胞fibrocyteの動態検索. Journal of Oral Biosciences Supplement (Web). 2017. 2017
-
細矢明宏, 建部廣明, 入江一元. 分泌タンパク質RELM-b/FIZZ2の歯根形成における役割. 北医療誌. 2017. 36(2). 47
ｍore...
Books (1)：
Education (2)：
- 2001 - Niigata University
- 1997 - Niigata University Faculty of Dentistry
Professional career (1)：
Work history (6)：
Awards (2)：
- 2009 - 歯科基礎医学会賞(第51回歯科基礎医学会総会)
- 2007 - デンツプライ賞(第125回日本歯科保存学会秋期大会)
Association Membership(s) (5)：
JAPANESE ASSOCIATION OF REGENERATIVE DENTISTRY
, 日本骨代謝学会
, 日本歯科保存学会
, 日本解剖学会
, 歯科基礎医学会
