Okada Tetsuya

オカダテツヤ | Okada Tetsuya

Affiliation and department：
Job title： Instuctor
Homepage URL (1)： http://www.users.kudpc.kyoto-u.ac.jp/~s50218/mori/

Research field (2)： Cell biology , Molecular biology

Research keywords (6)：構造異常タンパク質 , タンパク質の品質管理 , 小胞体ストレス , unfolded protein , Quality Control , ER stress

Research theme for competitive and other funds (7)：

2018 - 2021 Regulation of ER-localized mannosidase EDEM2 via the intermolecular disulfide bond
2015 - 2018 Substrate recognition mechanism of the endoplasmic reticulum-localized mannosidase EDEM
2014 - 2017 Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates
2011 - 2016 Establishment of high-throughput screening of toxic chemical compounds.
2009 - 2010 The activation mechanism of a membrane-bound transcription factor ATF6 in response to Endoplasmic Reticulum Stress

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Papers (40)：

Tomoyo Ikeda, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Masaya Ono, Kazutoshi Mori. Proteomic analysis of fatty liver induced by starvation of medaka fish larvae. Cell structure and function. 2023. 48. 2. 123-133
Byungseok Jin, Tokiro Ishikawa, Makoto Kashima, Rei Komura, Hiromi Hirata, Tetsuya Okada, Kazutoshi Mori. Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish. Life Science Alliance. 2023. 6. 7. e202201771-e202201771
Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori. Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice. Molecular Biology of the Cell. 2023
Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori. Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice. Molecular biology of the cell. 2023. mbcE22070292
Shunsuke Saito, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Kazutoshi Mori. A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b. eLife. 2022. 11

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MISC (7)：

蜷川暁, GEORGE Ginto, 矢木宏和, 住友嘉樹, 神谷由紀子, 石川時郎, 武田俊一, 佐久間哲史, 山本卓, 加藤晃一, et al. 高等動物におけるN型糖鎖トリミングを基軸とした小胞体関連分解機構の解析. 日本糖質学会年会要旨集. 2019. 38th
森和俊, 岡田徹也. 小胞体に存在する複数のオルガネラ・ゾーン. 生体の科学. 2018. 69. 6. 527-531
Tetsuya Okada, Satoshi Ninagawa, Kazutoshi Mori. Mannose trimming mechanism in endoplasmic reticulum-associated degradation of glycoproteins. Seikagaku. 2016. 88. 2. 257-260
岡田徹也. 生き物たちのつづれ織り(下) 第5章-1 「タンパク合成を支える細胞内システム」. 2012. 3-14
佐藤吉美, 灘中里美, 岡田徹也, 森和俊. 小胞体膜結合性転写因子ATF6を小胞体ストレス依存的に還元する仕組みの解析. 生化学. 2009

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Lectures and oral presentations (15)：

The regulation by OS9 and XTP3B in ER-associated degradation depends on the degree of structural abnormality of degradation substrates
(日本糖質学会年会要旨集 2021)
Super-resolution live cell imaging of endoplasmic reticulum stress-induced transport of the membrane-bound transcription factor ATF6.
(2020)
超解像イメージングによる小胞体ストレスセンサーATF6選別輸送ゾーンの解析
(第3回オルガネラ・ゾーン研究会 2019)
小胞体膜タンパク質Seipinの神経変性誘導変異体に起因する小胞体ストレス発生機構の解析
(日本生化学会大会プログラム・講演要旨集 2019)
小胞体ストレスセンサーATF6αはジスルフィド結合を介して2種類の二量体を形成する(Endoplasmic reticulum stress sensor ATF6α forms two types of dimers via disulfide-bonding)
(日本生化学会大会プログラム・講演要旨集 2019)

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Education (2)：

Professional career (2)：

Work history (2)：

Association Membership(s) (6)：

日本細胞生物学会 , 日本分子生物学会 , 日本生化学会 , Japan Society for Cell Biology , The Molecular Biology Society of Japan , The Japanese Biochemical Society

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