Rchr
J-GLOBAL ID：200901093780562141
Update date: Feb. 01, 2024
Sakasai Ryo
サカサイ リョウ | Sakasai Ryo
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
https://kmu-bc1.jimdo.com/
Research field (1)：
Applied molecular and cellular biology
Research keywords (2)：
DNA修復
, DNA repair
Research theme for competitive and other funds (11)：
- 2021 - 2024 Investigation for the regulatory mechanism of DNA double-strand break repair by nuclear myosin
- 2021 - 2024 Mechanisms for cell surface expression of chromatin in apoptotic cells
- 2021 - 2024 Cellular responses to DNA double-strand breaks caused by transcription stress
- 2018 - 2021 A role of DNA-damage repair protein 53BP1 in apoptotic cells.
- 2018 - 2021 Analysis of the contribution of transcription to homologous recombination pathway
- 2015 - 2018 Analysis of the mechanism of cell sensitivity against anti-cancer drug caused by ubiquitination-dependent DNA-PK activation
- 2014 - 2018 Regulation of DNA repair pathway choice and gene editing by DNA repair machinery
- 2014 - 2018 A DNA damage-independent role for 53BP1 in apoptotic cells
- 2012 - 2016 Analysis of cell death and repair pathway choice of DNA double-strand breaks caused by anti-cancer drug
- 2002 - DNAの非相同末端連結に伴うエラーとそのメカニズムの解析
- 2002 - analysis mechanisms of error-prone nonhomologous end-joining.
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Papers (20)：
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Ryo Sakasai, Tadashi Matsui, Yumi Sunatani, Kuniyoshi Iwabuchi. UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks. Biochemical and biophysical research communications. 2023. 668. 42-48
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Ryo Sakasai, Mitsuo Wakasugi, Tadashi Matsui, Yumi Sunatani, Masafumi Saijo, Tsukasa Matsunaga, Kuniyoshi Iwabuchi. Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair. DNA repair. 2022. 113. 103318-103318
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Teppei Shibata, Masahito Ikawa, Ryo Sakasai, Yasuhito Ishigaki, Etsuko Kiyokawa, Kuniyoshi Iwabuchi, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo. Lens-specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity. Mechanisms of Ageing and Development. 2021. 196
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Misaki Matsui, Ryo Sakasai, Masako Abe, Yusuke Kimura, Shoki Kajita, Wakana Torii, Yoko Katsuki, Masamichi Ishiai, Kuniyoshi Iwabuchi, Minoru Takata, et al. USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9. Oncogenesis. 2020. 9. 6. 60-60
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Yusuke Okamoto, Watal M Iwasaki, Kazuto Kugou, Kazuki K Takahashi, Arisa Oda, Koichi Sato, Wataru Kobayashi, Hidehiko Kawai, Ryo Sakasai, Akifumi Takaori-Kondo, et al. Replication stress induces accumulation of FANCD2 at central region of large fragile genes. Nucleic acids research. 2018. 46. 6. 2932-2944
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MISC (2)：
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逆井 良. DNA複製及び転写を介したDNA鎖切断 : トポイソメラーゼI阻害剤とDNA損傷応答 (特集 DNA二本鎖切断研究の新展開 : 総説). 放射線生物研究. 2011. 46. 4. 359-378
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Yosuke Ichijima, Ryo Sakasai, Naoyuki Okita, Kinji Asahina, Hirobumi Teraoka. Phosphorylation of histone H2AX at m phase in human cells without DNA damage response. CELL STRUCTURE AND FUNCTION. 2005. 30. 41-41
Education (4)：
- 2002 - 2006 Tokyo medical and Dental University
- - 2002 Nara Institute of Science and Technology Graduate School, Division of Biological Science Molecular Biology
- 1996 - 2000 Toho University Faculty of Science Department of Biology
- - 2000 Toho University department of biology
Professional career (1)：
Association Membership(s) (3)：
日本放射線影響学会
, 日本生化学会
, 日本分子生物学会
