Rchr
J-GLOBAL ID：200901093983719356
Update date: Feb. 01, 2024
Kuwajima Kunihiro
クワジマ クニヒロ | Kuwajima Kunihiro
Affiliation and department：
Job title：
Emeritus Professor
Other affiliations (1)：
Research field (4)：
Molecular biology
, Biophysics
, Structural biochemistry
, Molecular biochemistry
Research keywords (4)：
NMR
, ストップトフロー法
, 分子シャペロン
, 蛋白質フォールディング
Research theme for competitive and other funds (38)：
- 2020 - 2023 Residual Structures of Denatured Proteins Studied by Two-Dimensional NMR Using a Spin-Desalting Column
- 2016 - 2020 Studies on the protein-folding transition state based on correlation analysis of kinetic folding data and protein structure
- 2013 - 2016 Folding mechanism of non-two-state proteins based on correlation analyses of kinetic folding data
- 2008 - 2014 Management for Molecular Science of Fluctuations toward Biological Functions
- 2008 - 2013 Structural fluctuations and functional expression of the chaperonin complexes
- 2011 - 2012 Development of analytical method for structural change dynamics of biomolecules and its application
- 2008 - 2011 The second ATP-binding site of the chaperonin GroEL and its functional role
- 2003 - 2009 Chemistry of Biological Processes Created by Water and Biomolecules
- 2005 - 2008 Kinetic Studie on the Functional Expression of Chaperonin
- 2003 - 2008 Physicochemical interpretations of mechanism of protein folding
- 2002 - 2002 大腸菌シャペロニンの機能発現の速度論
- 2002 - 2002 蛋白質フォールディングの物理化学的解析
- 2000 - 2002 Studies on Protein Folding by the High-Pressure Temperature-Jump Method and Computer Simulations
- 2001 - 2001 蛋白質フォールディング研究の企画調査
- 1997 - 2001 Dynamic interaction between chaperone and its substrates
- 1997 - 2000 Search for new biological motors
- 1998 - 1999 Molecular Mechanism of Functional Expression of the Chaperonin
- 1995 - 1999 Administration of researches on principles of protein architecture
- 1995 - 1997 Molecular Mechanisms of Recognition of Target Proteins by the Chaperonin GroEL
- 1996 - 1996 分子シャペロンによる細胞機能制御
- 1995 - 1996 Study of folding mechanism of proline mutants of staphylococcal nuclease
- 1995 - 1996 Joint Study on the Mechanism of Protein Folding
- 1995 - 1995 Structure and function of stress proteins
- 1994 - 1995 Method for protein design based on module units.
- 1994 - 1995 Structures and Formation Mechanisms of Folding Intermediates of Proteins
- 1994 - 1994 タンパク質立体構造の構築原理
- 1994 - 1994 大腸菌のGroELにより認識されるタンパク質の中間構造状態の解析
- 1993 - 1993 水素交換ラベルと二次元NMRによるタンパク質の膜透過型分子構造の解析
- 1991 - 1993 Kinetic Studies of Protein Folding Using Protein Engineering
- 1992 - 1992 水素交換パルスラベルとNMR測定のためのプログラマブル多段混合装置の製作
- 1992 - 1992 新局面を迎えたタンパク質の構造、物性、機能研究に関する我国の現状分析と展望
- 1992 - 1992 水素交換ラベルと二次元NMRによるタンパク質の膜透過型分子構造の解析
- 1991 - 1991 タンパク質立体構造の構築原理を解明するための基礎研究
- 1989 - 1990 Studies on the Critical Structure of Protein Folding by Means of Site-Directed Amino Acid Replacements.
- 1986 - 1989 Characterization of Structural Intermediates of Proteins by Hydrogen Exchange Method
- 1985 - 1986 Analysis of Early Secodary Structure in Globular-Protein Folding.
- The Mechanism of Molecular Recognition of Chaperonins
- The Folding Mechanism of Globular Proteins
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Papers (136)：
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Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kunihiro Kuwajima. The B Domain of Protein A Retains Residual Structures in 6 M Guanidinium Chloride as Revealed by Hydrogen/Deuterium-Exchange NMR Spectroscopy. Protein science : a publication of the Protein Society. 2023. e4569
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Kunihiro Kuwajima, Maho Yagi-Utsumi, Saeko Yanaka, Koichi Kato. DMSO-Quenched H/D-Exchange 2D NMR Spectroscopy and Its Applications in Protein Science. Molecules (Basel, Switzerland). 2022. 27. 12
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Maho Yagi-Utsumi, Mahesh S Chandak, Saeko Yanaka, Methanee Hiranyakorn, Takashi Nakamura, Koichi Kato, Kunihiro Kuwajima. Residual Structure of Unfolded Ubiquitin as Revealed by Hydrogen/Deuterium-Exchange 2D NMR. Biophysical journal. 2020. 119. 10. 2029-2038
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Shimizu M, Kajikawa Y, Kuwajima K, Dobson CM, Okamoto Y. Determination of the structural ensemble of the molten globule state of a protein by computer simulations. Proteins. 2019. 87. 8. 635-645
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Cheng Q, Joung I, Lee J, Kuwajima K, Lee J. Exploring the Folding Mechanism of Small Proteins GB1 and LB1. Journal of chemical theory and computation. 2019. 15. 6. 3432-3449
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MISC (155)：
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Qianyi Cheng, Insuk Joung, Keehyoung Joo, Kunihiro Kuwajima, Jooyoung Lee. Folding Mechanisms of Small Proteins GB1 and LB1. BIOPHYSICAL JOURNAL. 2017. 112. 3. 60A-61A
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K. Makabe, K. Kuwajima. Folding kinetics of outer surface protein A. FEBS JOURNAL. 2014. 281. 410-411
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Terauchi Shun, Kamba Keisuke, Mori Yoshiharu, Sakae Yoshitake, Nakamura Takashi, Okamoto Yuko, Kuwajima Kunihiro, Maki Kosuke. 30aPS-98 The hydrogen bonds formation of Staphylococcal Nuclease at the Residue Level. Meeting abstracts of the Physical Society of Japan. 2014. 69. 1. 422-422
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刈谷 龍昇, 松田 幸樹, 中村 敬, 古水 雄志, 鈴木 元, 桑島 邦博, 上岡 龍一, 岡田 誠治. HAMLET/BAMLETの原発性滲出性悪性リンパ腫に対する抗腫瘍効果. 日本エイズ学会誌. 2013. 15. 4. 396-396
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KUWAJIMA Kunihiro. Protein Folding and Non-Folding. 2013. 62. 9. 498-498
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Books (7)：
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Antitumor Complexes Formed by Oleic Acid and Molten Globule Intermediates of Proteins
Springer, Tokyo, 2016 ISBN:9784431558408
-
Experimental and Simulation Studies of the Folding/Unfolding of Goat alpha-Lactalbumin
Springer - Verlag, Berlin & Heiderberg, 2009
-
Equilibrium and kinetically observed molten globule states.(review)
Wiley-VCH Verlag GmbH, Weinheim, 2005
-
The molten globule state : the physical picture and biological significance.
In Mechanisms of protein folding(Second edition). Edited by Pain R. H. Oxford University Press, Oxford. 2000
-
Molten globule. (review)
In Encyclopedia of Molecular Biology(Creighton, T. E. ed) John. Wiley & Sone, Inc. , New York. 1999
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Professional career (1)：
- DSc (Hokkaido University)
Work history (14)：
- 2013 - 2021/03 Tokyo University of Science Faculty of Industrial Science and Technology Part-time Lecturer (Protein Structures)
- 2013 - 2021/03 Korea Institute for Advanced Study (KIAS) School of Computational Sciences KIAS Scholar
- 2013/04 - 2015/03 Graduate University for Advanced Studies (Sokendai) Center for the Promotion of Integrated Sciences Adjunct Professor
- 2007 - 2013 SOKENDAI (The Graduate University for Advanced Studies) Department of Functional Molecular Science, School of Physical Sciences Professor
- 2007 - 2013 National Institutes of Natural Sciences Okazaki Institute for Integrative Bioscience and Institute for Molecular Science Professor
- 2013 - SOKENDAI (The Graduate University for Advanced Studies) Professor Emeritus
- 2013 - Institute for Molecular Science Professor Emeritus
- 2013 - The University of Tokyo Professor Emeritus
- 2008/04 - 2010/03 SOKENDAI (The Graduate University for Advanced Studies) School of Physical Sciences Dean
- 1999 - 2007 University of Tokyo Graduate School of Science Professor
- 1992 - 1999 University of Tokyo Faculty of Science (Graduate School of Science from 1993) Associate Professor
- 1983 - 1992 Hokkaido University Faculty of Science Assistant Professor
- 1975 - 1983 Hokkaido University Faculty of Science Research Associate
- 1980 - 1982 Stanford University Department of Biochemstry NIH International Fellow
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Committee career (8)：
- 2010/04 - 2012/03 The Protein Science Society of Japan President
- 2010/04 - 2012/03 日本蛋白質科学会 会長
- 2009/04 - 2011/03 Japanese Biophysical Society Head of Chubu Branch
- 2009/04 - 2011/03 日本生物物理学会中部支部 支部長
- 2005/09 - 2008/08 The Protein Society Executive Council
- 2006 - 2007 蛋白質科学会(Protein Society) Executive Council Member
- 1999/01 - 2001/12 Japanese Biophysical Society Steering Committee
- 1999 - 2000 日本生物物理学会 運営委員
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Association Membership(s) (6)：
日本化学会
, 日本物理学会
, 蛋白質科学会(Protein Society)
, 日本蛋白質科学会
, 日本生化学会
, 日本生物物理学会
