Yoshie Mikihiro

ヨシエミキヒロ | Yoshie Mikihiro

Research field (3)： Fetal medicine/Pediatrics , Obstetrics and gynecology , Pharmacology

Research keywords (9)：脱落膜化 , 着床 , 妊娠 , ovarian cancer , decidualization , trophoblast , placenta , stathmin , Epac

Research theme for competitive and other funds (10)：

2020 - 2023 子宮がん自然発症マウスモデルを用いたがん発生を制御する上皮・間質の相互応答の解明
2019 - 2022 Approaches to understanding the pathogenesis of pregnancy-induced hypertension using an endometrial organoid model
2016 - 2019 子宮・胎盤における非古典的プロゲステロン受容体の病態生理学的役割の解明
2015 - 2018 Regulatory mechanisms of inflammasome-mediated placental inflammation by alpha1-antitrypsin
2013 - 2015 Cyclic AMP signaling network in the decidualization of endometrial stromal cells

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Papers (64)：

Atsuya Tsuru, Mikihiro Yoshie, Mei Suzuki, Hiroki Mochizuki, Satoshi Kametaka, Takako Ohmaru-Nakanishi, Mana Azumi, Kazuya Kusama, Kiyoko Kato, Kazuhiro Tamura. Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line. The Journal of endocrinology. 2024. 260. 2
吉田佳乃子, 草間和哉, 安曇麻奈, 吉江幹浩, 田村和広, 小島淳哉, 小野政徳, 西洋孝. ミトコンドリア酵素ジヒドロオロト酸デヒドロゲナーゼは胎盤栄養膜細胞の融合を調節する. 東京医科大学雑誌. 2023. 81. 4. 434-435
Kazuya Kusama, Takumi Suzuki, Ryosuke Motohashi, Takumi Nobusawa, Koichiro Ota, Mana Azumi, Mikihiro Yoshie, Hiroaki Miyaoka, Kazuhiro Tamura. Cordyceps militaris Extract and the Main Component, Cordycepin, Modulate the Functions of Prostate Cancer Cells Partially Through the Adenosine A1 Receptor. Natural Product Communications. 2022. 17. 10. 1934578X2211308-1934578X2211308
Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, Kazuhiro Tamura. PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells. Biomolecules. 2022. 12. 8
Kazuya Kusama, Ayaka Satoyoshi, Mana Azumi, Mikihiro Yoshie, Junya Kojima, Yumi Mizuno, Masanori Ono, Hirotaka Nishi, Takeshi Kajihara, Kazuhiro Tamura. Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells. Frontiers in endocrinology. 2022. 13. 966455-966455

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MISC (55)：

Mikihiro Yoshie. THE 5ALPHA-REDUCTASE-MEDIATED PROGESTERONE METABOLISM AND ITS INVOLVEMENT IN THE DECIDUALIZATION OF HUMAN ENDOMETRIAL STROMAL CELLS. PLACENTA. 2017. 59. 178-179
N. Kuwabara, T. Kurihara, M. Yoshie, K. Tamura, M. Kutsukake, E. Tachikawa. Mechanism of cortisol production in adrenal cortical cells under the non-stress and stress conditions: role of cyclic AMP and calcium in vitro study. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017. 27. S623-S624
Mikihiro Yoshie, Kazuhiro Tamura, Ryo Yonekawa, Hirotaka Nishi, Keiichi Isaka, Naoko Kuwabara, Eiichi Tachikawa. POSSIBLE ROLES OF UTERINE PGRMC1 IN THE IMPLANTATION AND DECIDUALIZATION. PLACENTA. 2017. 57. 267-267
奥隅奈都希, 田村和広, 吉江幹浩, 大根田若菜, 石川源, 中井章人, 竹下俊行, 井坂惠一, 桑原直子, 立川英一. 絨毛栄養膜細胞におけるNLRP3インフラマソーム経路の意義. 日本内分泌学会雑誌. 2017. 92. 3. 827-827
桑原直子, 小澤史織, 斉藤萌菜美, 佐藤響, 張宇実, 吉江幹浩, 田村和広, 横須賀章人, 三巻祥浩, 佐藤弘人, et al. 副腎細胞におけるストレスホルモン分泌に対するリンゴ葉からの精製成分の影響. 日本生化学会大会(Web). 2017. 90th

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Education (2)：

- 2006 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy
- 2001 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy

Professional career (1)：

薬学博士 (東京薬科大学)

Work history (7)：

2021/04 - 現在東京薬科大学薬学部内分泌薬理学教室准教授
2020/04 - 2021/03 東京薬科大学薬学部薬理学教室准教授
2019/04 - 2020/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2015/04 - 2019/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2008/04 - 2015/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy

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Committee career (2)：

2014 - 現在日本胎盤学会学術評議員
2009 - 現在日本薬理学会学術評議員

Awards (5)：

2020/12 - 第25回日本生殖内分泌学会学術奨励賞子宮内膜間質細胞の脱落膜化過程における細胞老化とプロゲステロン受容体膜構成因子1 との関係
2015 - 第19回日本生殖内分泌学会学術講演会学術奨励賞
2008 - 第16回日本胎盤学会学術集会相馬賞
2008 - 第81回日本薬理学会年会年会優秀発表賞
2007 - The Y.W. Loke New Investigator Travel Award13th International Federation Placenta Association (IFPA) Meeting

Association Membership(s) (5)：

日本内分泌学会 , 日本薬学会 , 日本胎盤学会 , 日本生殖内分泌学会 , 日本薬理学会

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