Rchr
J-GLOBAL ID:200901094648779090
Update date: Apr. 17, 2024
Kametani Fuyuki
カメタニ フユキ | Kametani Fuyuki
Affiliation and department:
Job title:
Research Scientist
Homepage URL (1):
http://www.igakuken.or.jp/
Research field (2):
Neuroscience - general
, Neuroanatomy and physiology
Research keywords (10):
mass spectrometry analysis
, proteomics
, プロテオーム
, アミロイド線維タンパク
, アルツハイマー病
, アミロイド
, Proteome
, Amyloid fibril protein
, Alzheimer's disease
, Amyloid
Research theme for competitive and other funds (25):
- 2017 - 2020 Integrative pathology of Amyloidosis: Exploratory research on the basis of transmission phenomena
- 2016 - 2019 Molecular mechanisms of BACE1 dysregulation and synaptic degeneration in Alzheimer's disease
- 2014 - 2018 Analysis of Amyloid Related Proteins with Advanced Laser Microdissection
- 2015 - 2017 The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations
- 2014 - 2017 Development of preventive and therapeutic treatments based on the pathogenesis of the transmission of amyloidosis
- 2013 - 2016 Elucidation of the pathological upregulation of beta-secretase and its molecular regulation
- 2011 - 2014 Pathological Investigation of the Pathogenesis and Development of Preventive and Therapeutic Procedures for Amyloidosis
- 2011 - 2013 Comprehensive Proteome Analysis of Age-related Changes in Amyloid Like Aggregates
- 2010 - 2012 A study toward development of novel Alzheimer therapies based on the regulation ofβ-secretase function
- 2008 - 2010 Systemic analysis of amyloidosis using animal models
- 2010 - タンパク質ミスホールディング病発症機序のプロテオミクス解析
- 2007 - 2009 Regeneration research of peripheral nerve injury via macrophage stimulated by oxidized galectin-1
- 2007 - 2008 Elucidation of the regulation mechanisms of activity, expression and cellular localization of β-secretase in neuronal cells
- 2003 - 2004 Analysis of the regulation mechanism of β-secretase function
- 1998 - 2000 Influence of presenilin 1 on amyloid precursor protein processing
- 1997 - 1997 プレセニリン断片の細胞生物学的解析
- 1996 - 1996 プレセニリン分解酵素の分子生物学的解析
- 1996 - 1996 アルツハイマー病患者脳の可溶性β蛋白およびS182遺伝子産物の病因的意義の研究
- 1992 - 1992 アルツハイマー病脳におけるB/A4の産生とアミロイド線継形成に関する研究
- 1990 - 1991 Molecular biological study on the mechanism of neuronal degeneration using teratoma cells
- 1990 - 1990 アルツハイマ-病脳アミロイド形成機序に関する研究
- 1989 - 1989 アルツハイマ-病脳アミロイド形成機序に関する研究
- 1987 - 1989 Molecular biological study on modulatory effects of psychotropic agents on biosynthesis and metabolism of neuropeptides
- 1986 - 1989 Molecular biological, neurochemical and immunohistochemical studies of the senile dementia-Alzheimer's disease brains.
- Molecular pathology of Alzheimer's disease Mechanism of amyloid fibril formation
Show all
Papers (234):
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Shojiro Ichimata, Yukiko Hata, Tsuneaki Yoshinaga, Nagaaki Katoh, Fuyuki Kametani, Masahide Yazaki, Yoshiki Sekijima, Naoki Nishida. Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition: Comprehensive Analysis Using Immunohistochemistry, Proteomics, and a Literature Review. International Journal of Molecular Sciences. 2024
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河上 緒, 野中 隆, 原 範和, 宮下 哲典, 亀谷 富由樹, 鴻江 真維, 佐藤 祐太, 田平 万莉奈, 長谷川 舞衣, 月江 珠緒, et al. 新規L344F変異を有するPick diseaseの多面的病態解析. Dementia Japan. 2023. 37. 4. 662-662
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Yoshinori Tanaka, Shun-ichi Ito, Yuki Honma, Masato Hasegawa, Fuyuki Kametani, Genjiro Suzuki, Lina Kozuma, Kosuke Takeya, Masumi Eto. Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43. Journal of Biological Chemistry. 2023. 105272-105272
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Airi Tarutani, Fuyuki Kametani, Marina Tahira, Yuko Saito, Mari Yoshida, Andrew C Robinson, David M A Mann, Shigeo Murayama, Taisuke Tomita, Masato Hasegawa. Distinct tau folds initiate templated seeding and alter the post-translational modification profile. Brain. 2023
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Diana Arseni, Renren Chen, Alexey G Murzin, Sew Y Peak-Chew, Holly J Garringer, Kathy L Newell, Fuyuki Kametani, Andrew C Robinson, Ruben Vidal, Bernardino Ghetti, et al. TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP. Nature. 2023. 620. 7975. 898-903
more...
MISC (51):
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小林 杏子, 酒井 洋樹, 亀谷 富由樹, 村上 智亮. 犬の毛包腫瘍におけるアミロイド沈着の原因蛋白質同定の試み(続報). 日本獣医学会学術集会講演要旨集. 2021. 164回. [BO-31]
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亀谷富由樹, 松原知康, 安藤孝志, 長谷川一子, 村山繁雄, 吉田真理, 長谷川成人. 多系統萎縮症患者脳内に蓄積したαシヌクレインの翻訳後修飾の解析. Dementia Japan. 2020. 34. 4
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亀谷富由樹, 下沢明希, 長谷川成人. 固定神経変性疾患脳組織からのアミロイド関連タンパク質の抽出およびその網羅的解析. Dementia Japan. 2018. 32. 3
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亀谷富由樹, 下沢明希, 長谷川成人. 固定脳組織からのアミロイドおよびアミロイド様タンパク質の抽出およびその網羅的解析. 日本アミロイドーシス研究会学術集会プログラム・抄録集. 2018. 6th
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細川雅人, 野中隆, 新井哲明, 新井哲明, 亀谷富由樹, 近藤ひろみ, 秋山治彦, 長谷川成人. TDP-43proteinopathyモデルマウスの作製. 日本薬学会年会要旨集(CD-ROM). 2017. 137th. ROMBUNNO.27I-am09-1198]
more...
Books (1):
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Secretory derivatives of Alzheimer’s amyloid cursor protein in cerebrospinal fluid and brain: Only Kunitz-containing forms show amyloid immunoreactivity. Allsop D, Kennedy HE, Kametani F,
Alzheimer’s Disease: Advances in Clinical and basic research, John Wiley & Sons. Ltd. 1993
Education (2):
- - 1981 Tokyo Metropolitan University Faculty of Science Department of Chemistry
- - 1981 Tokyo Metropolitan University Faculty of Science
Professional career (1):
Association Membership(s) (2):
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