Mizuno Risuke

ミズノリスケ | Mizuno Risuke

Affiliation and department：
Homepage URL (1)： http://www.vet.ous.ac.jp/seminar/yakuri/

Research field (4)： Clinical pharmacy , Physiology , Biomaterials , Biomedical engineering

Research theme for competitive and other funds (24)：

2022 - 2025 腎臓排出リンパ管の局所RASは食塩感受性高血圧症の病態に関連する
2019 - 2022 Lymphatic vessels acquires inflammatory abilities
2019 - 2021 Development of new treatment for reproductive disorders with myosin phosphatase inhibitory factor
2019 - 2021 Lymphatic system facilitates amyloid beta clearance for dementia
2016 - 2019 Developmental research for treatment of salt-sensitive hypertension by regulation of lymphatic Na+ pump

2013 - 2015 Development of a new treatment for salt-sensitive hypertension by improvement of the lymphatic system

2010 - 2012 Improvement of peripheral microcirculation by a new gas transmitter delivery

2009 - 2011 Imaging of intracellular dynamics of Ca^<2+>-influx-associated molecules and its physiological significance in endothelial cells.

2007 - 2010 組織間隙からセンチネルリンパ節への特異的な薬物集積システムの開発

2007 - 2009 Basic and clinical research for evaluating micro-environmental changes in sentinel lymph node produced by micro-metastasis of carcinoma cell.

2008 - 2008 リンパ管壁への薬物伝達システムによるリンパ管機能再生に関する開発的研究

2005 - 2007 Developmental study for hybrid artificial lymph vessels:its potential role of permeability

2005 - 2007 Basic research of lymphangiogenesis for new treatment of lymph edema

2005 - 2006 前哨リンパ節(SLN)への癌転移因子解明のリンパ学的研究

2003 - 2005 Development of drug delivery system (DDS) target for the lymphatic system

2003 - 2004 前哨リンパ節への癌転移因子解明のリンパ生理学的研究

2003 - 2004 人工リンパ管開発のための培養リンパ管細胞を用いた基礎的研究

2001 - 2002 癌のリンパ行性転移モデルを利用した組織間隙・リンパ循環間の連繋機能の評価研究

1999 - 2000 Physiome and pathophysiome research projects for studying cooperative functions of interstitial space and lymphatic system.

1995 - 1996 DEVELOPMENT OF A NEW EXPERIMENTAL APPARATUS FOR STUDYING OF MECHANICAL ACTIVITY OF ISOLATED ARTERIOLES.

微小循環生理学実験機器の開発

歯肉微小循環調節機構における生理病態生理学的研究

骨内循環調節機構における生理病態生理学的研究

微小循環-リンパ循環の生理病態生理学研究

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Papers (50)：

Masashi Mukohda, Takanori Yano, Toshiyasu Matsui, Sho Nakamura, Jiro Miyamae, Kensuke Toyama, Ryoji Mitsui, Risuke Mizuno, Hiroshi Ozaki. Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats. Scientific Reports. 2023. 13. 1
Masashi Mukohda, Risuke Mizuno, Fumiyo Saito, Toshiyasu Matsui, Hiroshi Ozaki. Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway. American journal of physiology. Heart and circulatory physiology. 2022. 323. 6. H1118-H1129
Masashi Mukohda, Risuke Mizuno, Hiroshi Ozaki. [Gut microflora and metabolic syndrome: new insight into the pathogenesis of hypertension]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2022. 157. 5. 311-315
Masashi Mukohda, Sho Nakamura, Kosuke Takeya, Akira Matsuda, Takanori Yano, Mihiro Seki, Risuke Mizuno, Hiroshi Ozaki. Streptococcal Exotoxin Streptolysin O Causes Vascular Endothelial Dysfunction Through PKCβ Activation. The Journal of pharmacology and experimental therapeutics. 2021
Mukohda Masashi, Seki Mihiro, Nakamura Sho, Takeya Kosuke, Takanori Akira, Yano Takanori, Mizuno Risuke, Ozaki Hiroshi. Streptolysin O: a novel mediator of endothelial dysfunction. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 2-O-D3-2

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MISC (30)：

Masashi Mukohda, Toshiyasu Matsui, Hiroshi Ozaki, Risuke Mizuno. Lymphatic Contraction Was Enhanced In Spontaneously Hypertensive Rats. HYPERTENSION. 2020. 76
Mukohda Masashi, Nakamura Sho, Takeya Kosuke, Matsuda Akira, Yano Takanori, Mizuno Risuke, Ozaki Hiroshi. Bacterial toxin, streptolysin O caused vascular endothelial dysfunction: Relationship between dysbiosis and hypertension. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 2-O-061
Mukohda Masashi, Mizuno Risuke, Ozaki Hiroshi. Thoracic duct function was impaired in spontaneously hypertensive rat. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 0. 2-YIA-25
K. Hiwatashi, K. Doi, R. Mizuno, M. Yokosuka. Feasibility of measuring urine glucose concentrations by a digital meter in dogs and cats. Journal of Pet Animal Nutrition. 2018. 21. 2. 102-105
Masashi Isshiki, Risuke Mizuno, Mitsuhiro Nishimoto, Toshiro Fujita. A FRET-based Sensor Detects Caveolae as Spatially Distinct Ca2+Stores in Endothelial Cells. CIRCULATION. 2012. 126. 21

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Education (2)：

- 1995 Shinshu University
- 1991 Nippon Veterinary and Life Science University Faculty of Veterinary Science School of Veterinary Medicine

Professional career (2)：

PhD (Shinshu University)
DVM

Work history (7)：

2018 - 現在 Okayama University of Science
2015 - 2018 Tsukuba International University Faculty of Health Sciences
2014 - 2015 The University of Tokyo Graduate School of Agricultural and Life Sciences
2009 - 2014 The University of Tokyo Graduate School of Medicine
2000 - - 信州大学講師

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Committee career (3)：

日本微小循環学会評議員
日本リンパ学会評議員
日本生理学会評議員

Awards (2)：

2001 - 日本リンパ学会奨励賞
1996 - AHA NY State Affiliate Fellowship

Association Membership(s) (9)：

THE JAPANESE SOCIETY OF VETERINARY SCIENCE , 米国微小循環学会 , 米国生理学会 , JAPANESE SOCIETY FOR MEDICAL AND BIOLOGICAL ENGINEERING , 日本微小循環学会 , 日本リンパ学会 , 日本生理学会 , Microcirculatory Society Inc. , The American Physiological Society

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