Rchr

J-GLOBAL ID：200901095122397598 Update date: Feb. 01, 2024

Ito Takaaki

イトウタカアキ | Ito Takaaki

Affiliation and department：
Job title： Professor

Research field (4)： Developmental biology , Cell biology , Experimental pathology , Human pathology

Research theme for competitive and other funds (45)：

2020 - 2024 小細胞肺癌でのがん免疫療法における、mTOR阻害剤併用の有用性の検証
2020 - 2024 Signal molecules of ASCL1, a lineage-specific transcription factor for small cell carcinoma of the lung
2018 - 2021 マウス胎仔単離肺上皮器官培養による小細胞肺癌モデルの開発
2017 - 2020 Development of a method to predict prognosis and treatment effect based on estrogen receptor expression level
2016 - 2018 Investigation of the mechanisms of regulating tumor microenvironment by secreted micro RNA from intractable oral cancer, and development a new treatment strategy

2015 - 2018 Hydrogen sulfide and sulfur oxdies production failure model: metabolic disorder in sulfurtransferase-knockout mice

2014 - 2017 Development of the stainier and SPECT probe for the diagnosis of CXCR4 expression in small cell lung carcinoma

2012 - 2017 Identification of stem cells from oncogenic mouse lungs by epithelial growth factor receptor gene mutation

2014 - 2016 Functional analysis of oral cancer stem cell-related microRNAs and development of novel therapies

2014 - 2016 混合型小細胞肺癌の発生機構:Notchシグナルからの解明

2012 - 2015 Comprehensive study of sulfurtransferase-knockout mice associated with insufficiency of hydrogen sulfide production

2012 - 2014 Investigation of the function of nucleostemin in oral squamous cell carcinoma and develop the new therapeutic approoach

2011 - 2013 Analysis of beta-Catenin/Sox2/p63 Signal Pathway in Lung Epithelial Differentiation and Tumorigenesis

2009 - 2012 肺特異的遺伝子改変マウスを用いた肺上皮・癌幹細胞研究:スフェア形成法による解析

2010 - 2012 単一細胞解析法による肺上皮細胞の発現遺伝子プロファイリング

2009 - 2011 Involvement of oxidative stress in the pathogenesis of ARDS associated with viral pneumonia

2008 - 2010 Molecular mechanisms coordinating between cell cycle and differentiation in lung epithelial cells

2007 - 2008 癌幹細胞の病理組織切片における同定と臨床病理学

2007 - 2008 Expression of Choline kinase on lung adenocarcinoma with correlationto 11C-acetate positron emission tomography

2007 - 2008 Involvement of nitrative stress due to influenza virus infection on the pathogenesis and progression of interstitial pneumonias

2006 - 2007 Involvement of MCAF1-MBD1 complex in hererochromatin formation and nuclear atypia. (2006)

2006 - 2007 Mechanism of lung differentiation : Notch, Stat signaling pathway

2005 - 2007 Beakc Research of Molecular Imaging on Familial Amyloiclotic Ployneuropathy

1997 - 2007 Tissue and cell injury and regeneration

2004 - 2005 Mechanisms of neuroendocrine differentiation of lung carcinoma cells and their cell biological siginifcances : trials from the points of proteomics analyses

2002 - 2003 The investigation on the expression regulation and the role on chemosensitivity of a xenobiotic enzyme GSTP1 in lung cancer.

2002 - 2003 Establishment of tumor immunotherapy using class II

2001 - 2002 GENE THERAPY TARGETTING FOR GLUCOSE METABLOLISM IN PACREAS CANCER

2001 - 2002 Significance of Notch signaling in cell fact determination of lung

1999 - 2000 The regulation of insulin targeted cell proliferation and differentiation in the insulin resistance ; the role of expression of glucose transporters

1999 - 2000 Network of proneural basic helix-loop-helix transcription factors for regualtion of pulmonary neuroendocrine cells.

1998 - 2000 Flt3-ligandを用いた樹状細胞と特異的T細胞誘導による癌性腹膜炎の制圧

1997 - 1998 Evaluation of the mechanism of amelioration of insulin resistance induced by dehydroepiandrosterone

1996 - 1997 Alterations in intracellular metabolism and apoptosis in cancer cachexia Difference between tumor-bearing hosts and cancer cells

1997 - 肺癌の分化調節機構

1997 - Mechanisms of cell differentiation of lung carcinomas

1995 - 1996 MECHANISM OF INSULIN SIGNAL ON GLUCOSE TRANSPORT IN KNOCKOUT MICE

1995 - 1996 Cell Adhesion Molecules and Growth Factors for Cytodifferentiation and Proliferation of Pulmonary Endocrine Cells

1995 - 1996 Cardiac cachexia -pathophysiology and its mechanisms-

1994 - 1995 Is caner a glucose eater?

1993 - 1994 Mechanisms of insulin resistance in the tumor-bearing state

1991 - 1993 Metabolic Alterations associated with Cancer Cachexia An analysis of mechanisms from microstructure and molecular biology-

1990 - 1991 Role of Epidermal Growth Factor in Growth and Regeneration of Adult Human Airway Epithelium

1985 - 1987 細気管支無線毛(Clara)細胞の代謝活性と細胞動態

神経ガイダンス分子ー受容体を標的とした新たな小細胞肺癌制御機構

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Papers (265)：

Masaya Yamazaki, Shinjiro Hino, Shingo Usuki, Yoshihiro Miyazaki, Tatsuya Oda, Mitsuyoshi Nakao, Takaaki Ito, Kazuya Yamagata. YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperproliferation in pancreatic cancer. EMBO J. 2023. 42. 14. e112614
Mune Sanada, Masaya Yamazaki, Tatsuya Yamada, Kosuke Fujino, Shinji Kudoh, Yuki Tenjin, Haruki Saito, Noritaka Kudo, Younosuke Sato, Akira Matsuo, et al. Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer. Human Cell. 2022. 36. 1. 409-420
Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K, Tamura M, Oike Y, et al. SIRT7 deficiency extends lifespan in male mice with an increase of fibroblast growth factor 21. Cells. 2022. 11. 12. 3609
Keiichi Nakahara, Koutaro Takamatsu, Noritaka Kudo, Takaaki Ito, Mitsuharu Ueda. Histopathological Features of Gerhardt Syndrome in a Patient With Multiple System Atrophy: An Autopsy Case Report. Cureus. 2022. 14. 10. e30415
Takaaki Ito, Shinji Kudoh, Kosuke Fujino, Mune Sanada, Yuki Tenjin, Haruki Saito, Yuko Nakaishi-Fukuchi, Hiroki Kameyama, Takaya Ichimura, Naoko Udaka, et al. Pulmonary neuroendocrine cells and small cell lung carcinoma: Immunohistochemical study focusing on mechanisms of neuroendocrine differentiation. ACTA HISTOCHEMICA ET CYTOCHEMICA. 2022. 55. 3. 75-83

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MISC (89)：

Junki Sakata, Ryoji Yoshida, Yuichiro Matsuoka, Kenta Kawahara, Hidetaka Arita, Hikaru Nakashima, Akiyuki Hirosue, Hisaki Naito, Hisashi Takeshita, Sho Kawaguchi, et al. FOXP3 lymphocyte status may predict the risk of malignant transformation in oral leukoplakia. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2020. 32. 1. 33-39
佐藤陽之輔, 松尾顕, 工藤信次, 長谷川功紀, 長谷川功紀, 伊藤隆明. 肺癌における新しいガイダンス分子であるドラキシンについて. 日本病理学会会誌. 2018. 107. 1
Takaaki Ito, Shinji Kudoh, Takaya Ichimura, Kosuke Fujino, Wael Ahmed Maher Abdo Hassan, Naoko Udaka. Small cell lung cancer, an epithelial to mesenchymal transition (EMT)-like cancer: significance of inactive Notch signaling and expression of achaete-scute complex homologue 1. HUMAN CELL. 2017. 30. 1. 1-10
Fujino Kosuke, Kazuhiro Yasufuku, Makoto Suzuki, Takaaki Ito. INSM1 is a Novel Biomarker and a Crucial Regulator of the Neuroendocrine Differentiation Pathway in Neuroendocrine Tumors of the Lung. JOURNAL OF THORACIC ONCOLOGY. 2017. 12. 1. S404-S405
Takamasa Koga, Kosuke Fujino, Kentaro Yoshimoto, Koei Ikeda, Yonosuke Sato, Takaaki Ito, Takeshi More, Makoto Suzuki. Recurrence and Survival Outcome after Segmentectomy for Non-Small Cell Lung Cancer: A Long-Term Follow-Up Study at a Single Institute. JOURNAL OF THORACIC ONCOLOGY. 2017. 12. 1. S637-S638

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Books (1)：

病理組織学的鑑別診断:肺の神経内分泌癌との比較を中心に
金原出版・Merkel細胞・Merkel細胞癌この謎多き細胞達(小野友道、鈴木啓之編) 2005

Lectures and oral presentations (8)：

The molecular regulation of differentiation, proliferation and highly malignancy character of small cell lung cancer by proteomic analysis of post-translational modification
(14th International Congress of Histochemistry and Cytochemistry 2012)
Significance of stat3-Hes1 system in mouse fetal lung epithelial differentiation
(14th International Congress of Histochemistry and Cytochemistry 2012)
Mutant epidermal growth factor receptor reduces expression of Notch receptors and modifies lung epithelial differentiation.
(14th International Congress of Histochemistry and Cytochemistry 2012)
Significance of Notch signaling in biology and pathology of lung carcinoma cell lines.
(14th International Congress of Histochemistry and Cytochemistry 2012)
マウス肺におけるメチル化DNA結合蛋白質MeCP2の発現.
(日本組織細胞化学会 2005)

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Works (7)：

MCAF抗体を用いた新たなガン診断マーカー
2007 - 2008
癌幹細胞の病理組織切片における同定と臨床病理学的意義
2007 - 2008
牛深地域の疾患の病理学的研究
2006 - 2008
炎症性疾患におけるガレクチン9の役割と探索
2005 - 2007
肺発生過程における肺神経内分泌細胞分化と低酸素シグナルについて
2005 - 2007

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Education (4)：

- 1985 Yokohama City University
- 1985 Yokohama City University Graduate School, Division of Medicine
- 1980 Yokohama City University
- 1980 Yokohama City University Faculty of Medicine

Professional career (1)：

Doctor of Medicine (Yokohama City University)

Work history (10)：

2021/04 - 現在 Kumamoto Health Science University Faculty of Health Science Dpartment of Medical Technology Professor
2010 - 2021/03 Kumamoto University Faculty of Life Sciences Department of pathology and experimental Medicine Professor
2003 - 2009 Kumamoto University
1995 - 2003 Yokohama City University
1991 - 1995 Yokohama City University

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Committee career (2)：

1989 - 2021/03 日本病理学会学術評議員
1992 - 日本組織細胞化学会評議員

Awards (3)：

2021/04 - 日本病理学会病理学会賞
2001 - 病理学会 A演説(学術研究賞)
2000 - 横浜医学会賞

Association Membership(s) (3)：

日本組織細胞化学会 , 日本病理学会 , 肺癌学会

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