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J-GLOBAL ID：200901095134589166   Update date: Feb. 01, 2024

Shimokawa Takashi

Shimokawa Takashi | Shimokawa Takashi
Affiliation and department：
Toho University Graduate School of Science

About Toho University Graduate School of Science


Other affiliations (1)：
Research field  (4)： Tumor biology ,  Radiology ,  Cell biology ,  Molecular biology
Research keywords  (3)： Heavy ion cancer treatment / non cancer treatment ,  radiation biology, ion beam breeding ,  Hedgehog PTCH GLI Rhabdomyosarcoma medulloblastoma, splice variant
Research theme for competitive and other funds  (9)：
  • 2020 - 2023 Development of novel cancer treatment to overcome acquired resistance mechanisms in synthetic lethal therapy targeting DNA repair
  • 2019 - 2023 重粒子線局所照射によるカンキツ類の突然変異体誘発に関する研究
  • 2019 - 2022 Development of radioprotectors that selectively protect normal tissues
  • 2019 - 2022 Quantitative evaluation of radiation-induced immunostimulating effect
  • 2016 - 2017 がん細胞のX線及び炭素イオン線抵抗性における細胞膜修復能に関する研究
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Papers (63)：
  • Lin Xie, Lulu Zhang, Kuan Hu, Masayuki Hanyu, Yiding Zhang, Masayuki Fujinaga, Katsuyuki Minegishi, Takayuki Ohkubo, Kotaro Nagatsu, Cuiping Jiang, et al. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell reports. Medicine. 2023. 4. 4. 100960-100960
  • Daniel K Ebner, Takashi Shimokawa, Walter Tinganelli, Charlot Vandevoorde. Editorial: New frontiers in radiobiology. Frontiers in public health. 2023. 11. 1181656-1181656
  • Mari Amino, Masatoshi Yamazaki, Koichiro Yoshioka, Noboru Kawabe, Sachie Tanaka, Takashi Shimokawa, Ryoko Niwa, Naoki Tomii, Shigeto Kabuki, Etsuo Kunieda, et al. Heavy Ion Irradiation Reduces Vulnerability to Atrial Tachyarrhythmias - Gap Junction and Sympathetic Neural Remodeling. Circulation journal : official journal of the Japanese Circulation Society. 2022
  • Takuya Noguchi, Ryuji Nishiyama, Takashi Shimokawa, Katsushige Yamada, Yusuke Kagawa. Simultaneous production of cellobiose and xylobiose from alkali-treated bagasse using cellulase secreted by Fe-ion-irradiated Trichoderma reesei mutant. Journal of bioscience and bioengineering. 2022. 134. 6. 491-495
  • Doudou Zhang, Takashi Shimokawa, Qianqian Guo, Shingo Dan, Yoshio Miki, Shigeaki Sunada. Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break. Cancer science. 2022. 114. 3. 1108-1117
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MISC (59)：
  • 加川雄介, 野口拓也, 下川卓志. “重イオンビーム”どうでしょう?. 生物工学会誌. 2023. 101. 7
  • 森田明典, WANG Bing, 田中薫, 勝部孝則, 村上正弘, 下川卓志, 西山祐一. Evaluation of cell death regulatory agents for protecting particle beam-irradiated mice. 量子科学技術研究開発機構研究報告書(Web). 2022. 26
  • 網野真理, 網野真理, 株木重人, 国枝悦夫, 橋本順, 菅原章友, 下川卓志, 柳下敦彦, 伊苅裕二, 吉岡公一郎. Stereotactic body radiotherapy (SBRT) for refractory ventricular techycardia (VT). 循環器内科. 2021. 90. 4. 453-462
  • 網野真理, 網野真理, 株木重人, 国枝悦夫, 橋本順, 菅原章友, 下川卓志, 柳下敦彦, 伊苅裕二, 吉岡公一郎. New generation treatment of intractable ventricular arrhythmia by extracorporeal radiation therapy. 臨床放射線. 2021. 66. 8. 757-765
  • 森田明典, WANG Bing, 田中薫, 勝部孝則, 村上正弘, 下川卓志, 西山祐一, 根井充. Evaluation of cell death regulatory agents for protecting particle beam-irradiated mice. 量子科学技術研究開発機構研究報告書(Web). 2021. 20
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Patents (3)：
Education (3)：
  • 1996 - 2000 The University of Tokyo Graduate School of Medicine Department of Radiological Health
  • 1994 - 1996 Toho University Graduate School of Science
  • 1990 - 1994 Toho University Faculty of Science Department of Biomolecular Science
Professional career (2)：
  • Dr. of Medical Science (The University of Tokyo)
  • (BLANK) (Toho University)
Work history (9)：
  • 2021/04 - 現在 National Institutes for Quantum and Radiological Science and Technology
  • 2016/04 - 2021/03 National Institutes for Quantum and Radiological Science and Technology National Institute of Radiological Sciences
  • 2011 - 2016/03 National Institute of Radiological Sciences
  • 2004 - 2011 Karolinska Institutet
  • 2004 - 2011 Department of Biosciences and Nutrition, Center for Biosciences, Karolinska Institutet, Sweden
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Committee career (3)：
  • 2022/06 - 現在 PTCOG Biology sub-committee
  • 2021/09 - 現在 一般社団法人 量子医科学会 学術行事委員会 委員
  • 2016/04 - 2018/03 一般社団法人 日本放射線影響学会 学術評議委員
Association Membership(s) (1)：
日本量子医科学会
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