Rchr
J-GLOBAL ID:200901095635197918   Update date: Feb. 15, 2024

Nakanishi Ikuo

ナカニシ イクオ | Nakanishi Ikuo
Affiliation and department:
Job title: Team Leader
Homepage URL  (1): http://ikuo.com/
Research field  (5): Pharmaceuticals - analytical and physicochemistry ,  Biochemistry ,  Bioorganic chemistry ,  Structural/physical organic chemistry ,  Basic physical chemistry
Research keywords  (9): Redox Chemistry ,  Electron Spin Resonance ,  Kinetics ,  Reaction Mechanism ,  Radical ,  電子移動 ,  Antioxidant ,  Reactive Oxygen Species ,  Physical Chemistry for Life Science
Research theme for competitive and other funds  (13):
  • 2018 - 2021 Kinetic Activity Evaluation of Antioxidants in Aqueous Solutions Using a Water-Solubilized Organic Radical
  • 2014 - 2017 Development of pH-Responsive Antioxidants as Radioprotectors for Normal Tissues
  • 2011 - 2014 Development of Novel Antioxidants Based on Thermodynamic Parameters Calculated by Density Functional Theory
  • 2009 - 2011 Mechanistic Study on the Pro-oxidant Effects by Antioxidants
  • 2006 - 2010 放射線治効果の向上に関する生物学的研究
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Papers (122):
  • Daisuke Masuda, Ikuo Nakanishi, Kei Ohkubo, Hiromu Ito, Ken-ichiro Matsumoto, Hiroshi Ichikawa, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Manas Kotepui, Motoki Imai, et al. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress-Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?. Biomolecules. 2024. 14. 1. 128-128
  • Yoshihiro Kawabata, Tomoko Fukushige, Hiroko P. Indo, Ken-ichiro Matsumoto, Megumi Ueno, Ikuo Nakanishi, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Sirirat Surinkaew, Jitbanjong Tangpong, et al. Hair Follicle Damage after 100 mGy Low-Dose Fractionated X-Ray Irradiation and the Protective Effects of TEMPOL, a Stable Nitroxide Radical, against Radiation. Radiation Research. 2024
  • Hiromu Ito, Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara, Ikuo Nakanishi. Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog. ACS Medicinal Chemistry Letters. 2024. 15. 2. 310-313
  • Hiromu Ito, Yoshimi Shoji, Megumi Ueno, Ken-ichiro Matsumoto, Ikuo Nakanishi. Photodynamic Therapy for X-ray-Induced Radiation-Resistant Cancer Cells. Pharmaceutics. 2023. 15. 11. 2536-2536
  • Hiromu Ito, Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara, Ikuo Nakanishi. Anti-cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential. ACS Medicinal Chemistry Letters. 2023. 14. 10. 1478-1481
more...
MISC (99):
  • Ikuo Nakanishi, Yoshimi Shoji, Kei Ohkubo, Toshihiko Ozawa, Ken-ichiro Matsumoto, Shunichi Fukuzumi. pH Effect on the Scavenging Rates of Ascorbic Acid against Selected Radicals in Phosphate Buffer Solutions. Free Radical Biology and Medicine. 2022. 180. Supplement 1. s64-s64
  • 稲庭拓, 鈴木雅雄, 岩田義之, 佐藤眞二, 水島康太, 下川卓志, 阿部康志, 坂田洞察, 長谷川純崇, 中島菜花子, et al. Studies for Magneto-Particle Therapy. 量子科学技術研究開発機構研究報告書(Web). 2020. 17
  • Hideyuki Majima, Hiromu Ito, Tomoko Fukushige, Hiroko Indo, Yoshihiro Kawabata, Ken-Ichiro Matsumoto, Ikuo Nakanishi, Akihide Tanimoto, Takuro Kanekura, Clare Hawkins, et al. Effects of Extremely Small Doses, 100 mGy a Day, Five Times a Week, Total of Twelve Weeks of Low-Dose Fractionated X-irradiation on Mice Hair Root. FREE RADICAL BIOLOGY AND MEDICINE. 2019. 145. S31-S32
  • Yusuke Makino, Emiko Sekine-Suzuki, Minako Nyui, Megumi Ueno, Ikuo Nakanishi, Koji Fukui, Ken-ichiro Matsumoto. Quantification of X-ray nduced Hydrogen Radicals in an Aqueous Solution Using EPR Spin Trapping. FREE RADICAL BIOLOGY AND MEDICINE. 2019. 145. S32-S32
  • Ikuo Nakanishi, Yoshimi Shoji, Kei Ohkubo, Toshihiko Ozawa, Ken-ichiro Matsumoto. Kinetic Isotope Effect in the Reaction of Water Soluble Antioxidants with Water-Solubilized 2,2Diphenyl-l-picrylhydrazyl Radical in Aqueous Buffer Solutions. FREE RADICAL BIOLOGY AND MEDICINE. 2019. 145. S34-S34
more...
Patents (4):
  • SCREENING METHOD, SCREENING KIT AND ANALYSIS PROGRAM
  • スクリーニング方法、スクリーニングキット、及び解析プログラム
  • 酵母を有効成分とする放射線防護剤
  • N-フッ素化アルキルピペリジンメタノール誘導体及びこれを含有する中枢局所アセチルおよびブチリルコリンエステラーゼ活性測定用試薬
Books (4):
  • Generation of Oxygen Radicals and DNA-Cleaving Ability in Quinone/NADH System
    Magnetic Resonance in Medicine 2002
  • フラーレンの光増感反応による活性酸素生成とDNA損傷のメカニズム
    <i>放射線科学</i> 2002
  • Generation of Oxygen Radicals and DNA-Cleaving Ability in Quinone/NADH System
    Magnetic Resonance in Medicine 2002
  • Mechanism of Generation of Reactive Oxygen Species and DNA Damage by Photosensitized Reactions of Fullerenes
    Radiological Sciences 2002
Lectures and oral presentations  (4):
  • 抗酸化物質によるラジカル消去反応の量子生命科学
    (Free Radical School 2023 2023)
  • 抗酸化物質によるラジカル消去機構の解明
    (量子生命科学サマーセミナー2023)
  • 抗酸化物質によるラジカル消去機構の解明〜分子から量子へ
    (Free Radical School 2022 2023)
  • 抗酸化物質によるラジカル消去反応機構の量子論的解析
    (科学的根拠に基づく健康長寿を伸ばす会(PH会)第21回講演会 2022)
Education (3):
  • 1996 - 1999 Osaka University Graduate School of Engineering Department of Material and Life Science
  • 1994 - 1996 Osaka Prefecture University Graduate School of Engineering Department of Applied Chemistry
  • 1990 - 1994 Osaka Prefecture University Faculty of Engineering Department of Applied Chemistry
Professional career (1):
  • Ph.D. (Osaka University)
Work history (13):
  • 2022/04 - 現在 National Institutes for Quantum Science and Technology Quantum RedOx Chemistry Team, Institute for Quantum Life Science, Quantum Life and Medical Science Directorate Team Leader
  • 2021/04 - 2022/03 National Institutes for Quantum and Radiological Science and Technology Quantum Redox Chemistry Group, Institute for Quantum Life Science, Quantum Life and Medical Science Directorate Group Leader
  • 2019/04 - 2021/03 National Institutes for Quantum and Radiological Science and Technology Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Quantum Medical Science Directorate Senior Principal Researcher
  • 2010/12 - 2021/03 Shibaura Institute of Technology Graduate School of Engineering and Science Visiting Professor
  • 2018/07 - 2019/03 National Institutes for Quantum and Radiological Science and Technology Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences Senior Principal Researcher
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Committee career (14):
  • 2023/06 - 現在 一般社団法人 日本抗加齢医学会 評議員
  • 2020/12 - 現在 一般社団法人 日本酸化ストレス学会 総務委員
  • 2020/12 - 現在 一般社団法人 日本酸化ストレス学会 学会賞・学術賞・功労賞選考委員
  • 2020/01 - 現在 一般社団法人電子スピンサイエンス学会 代議員
  • 2018/04 - 現在 一般社団法人日本酸化ストレス学会 代議員
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Awards (8):
  • 2019/06 - Society for Free Radical Research Japan (SFRR Japan) The SFRR Japan Award of Scientific Excellence
  • 2010/10 - The Society of Pure & Applied Coordination Chemistry (SPACC) The SPACC Young Investigator Award Metal Ion-Accelerated Radical-Scavenging Reactions of Phenolic Antioxidants
  • 2009/06 - AOB研究会 AOB (Anti-Oxidant Biofactor)研究会奨励賞 金属イオン存在下におけるビタミンEモデルに由来するフェノキシルラジカルのキャラクタリゼーション
  • 2008/10 - The Society of Electron Spin Science and Technology (SEST) SEST Young Investigator Award
  • 2008 - 国際フリーラジカル学会SFRR Japan Young Investigator Award 2008
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Association Membership(s) (11):
Quantum Life Science Society ,  THE JAPAN RADIATION RESEARCH SOCIETY ,  Japanese Society of Anti-Aging Medicine ,  Society for Free Radical Research JAPAN ,  The Society of Electron Spin Science and Technology (SEST) ,  The Pharmaceutical Society of Japan ,  The Chemical Society of Japan ,  The Society of Pure & Applied Coordination Chemistry (SPACC) ,  ビタミンE研究会 ,  Society for Redox Biology and Medicine (SfRBM) ,  AMERICAN CHEMICAL SOCIETY
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