Mitsuru Okuwaki

オクワキミツル | Mitsuru Okuwaki

Affiliation and department：
Homepage URL (1)： https://www.kitasato-u.ac.jp/pharm/

Research field (4)： Molecular biology , Cell biology , Virology , Genetics

Research theme for competitive and other funds (15)：

2017 - 2020 Regulation of gene expression by histone chaperones
2017 - 2020 Oncogenic mechanisms by nucleoporin
2014 - 2017 A novel mechanism of cell growth regulation by the intrinsically disordered protein, NPM1
2013 - 2016 Dynamic regulation of chromatin by histone chaperone
2009 - 2014 Regulatory functions of IDPs in the nuclear network of the genetic information systems

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Papers (64)：

Mitsuru Okuwaki, Shin-Ichiro Ozawa, Shuhei Ebine, Motoki Juichi, Tadanobu Umeki, Kazuki Niioka, Taiyo Kikuchi, Nobutada Tanaka. The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets. Journal of biochemistry. 2023
Sadik Cigdem, Shoko Saito, Daiki Nishikata, Kyosuke Nagata, Mitsuru Okuwaki. SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 10. 830-837
Hiroko Hirawake-Mogi, Nguyen Thi Thanh Nhan, Mitsuru Okuwaki. G-patch domain-containing protein 4 localizes to both the nucleoli and Cajal bodies and regulates cell growth and nucleolar structure. Biochemical and Biophysical Research Communications. 2021. 559. 99-105
Mitsuru Okuwaki, Ai Saotome-Nakamura, Masashi Yoshimura, Shoko Saito, Hiroko Hirawake-Mogi, Takeshi Sekiya, Kyosuke Nagata. RNA-recognition motifs and glycine and arginine-rich region cooperatively regulate the nucleolar localization of nucleolin. The Journal of Biochemistry. 2021. 169. 1. 87-100
Mitsuru Okuwaki, Shoko Saito, Hiroko Hirawake-Mogi, Kyosuke Nagata. The interaction between nucleophosmin/NPM1 and the large ribosomal subunit precursors contribute to maintaining the nucleolar structure. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2021. 1868. 1. 118879-118879

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MISC (16)：

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Books (10)：

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Lectures and oral presentations (21)：

ヒト血液サンプルにおけるNUDT15酵素活性の測定
(日本薬学会第143年会 2023)
微生物由来抗結核剤 calpinactam の標的分子の解析
(日本薬学会第143年会 2023)
Mechanism of transcriptional activation regulation of C/EBPa in leukemia associated with the translocated fusion gene product DEK-NUP214
(2022)
ALS関連遺伝子のリピート配列伸長が核小体構造に与える影響の検討
(第44回日本分子生物学会年会 2021)
翻訳開始位置変動がNPM1の多量体形成能と液-液相分離能へ与える影響
(第44回日本分子生物学会年会 2021)

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Education (2)：

- 1999 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering
- 1994 Tokyo Institute of Technology Faculty of Life Science and Engineering

Work history (6)：

2018/04 - 現在 Kitasato University School of Pharmacy Professor
2007/12 - 2018/03 University of Tsukuba University of Tsukuba Associate Professor
2004/04/01 - 2007/11/30 University of Tsukuba
2003/05/16 - 2004/03/31 University of Tsukuba Institute of Basic Medical Sciences
2002/04/01 - 2003/05/15 Cancer Research UK Research Fellow

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Association Membership(s) (3)：

日本薬学会 , The Molecular Biology Society of Japan , THE JAPANESE BIOCHEMICAL SOCIETY

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