Rchr
J-GLOBAL ID：200901096299224304   Update date: Feb. 01, 2024

Noguchi Jun

ノグチ ジュン | Noguchi Jun
Affiliation and department：
National Center of Neurology and Psychiatry National Institute of Neuroscience,Ncnp

About National Center of Neurology and Psychiatry National Institute of Neuroscience,Ncnp


Research field  (3)： Physiology ,  Neuroscience - general ,  Neuroanatomy and physiology
Research keywords  (5)： Autism spectrum disorder ,  in vivo イメージング ,  カルシウム ,  樹状突起スパイン ,  樹状突起
Research theme for competitive and other funds  (9)：
  • 2022 - 2025 Two-photon microscopy of the pathophysiology of synapses in animal models of autism spectrum disorder
  • 2018 - 2021 Alterations in synaptic stability and trials of their adjustment in autism model marmosets
  • 2014 - 2017 Analysis of the properties of synaptic back propagating signal
  • 2014 - 2016 脳内環境がスパイン形態可塑性に与える影響の解析
  • 2009 - 2014 Cerebral spine synapses and exocytosis studied with two-photon microscope
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Papers (29)：
  • Hasan Ucar, Satoshi Watanabe, Jun Noguchi, Yuichi Morimoto, Yusuke Iino, Sho Yagishita, Noriko Takahashi, Haruo Kasai. Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis. Nature. 2021. 600. 7890. 686-689
  • Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, et al. Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease. Nature communications. 2021. 12. 1. 5388-5388
  • Noguchi, J, Nagaoka A, Hayama, T, Ucar H, Yagishita, S, Takahashi, N, Kasa, H. Bidirectional in vivo dendritic spine plasticity revealed by two-photon glutamate uncaging in the mouse neocortex. Sci Rep. 2019. 9. 1. 13922-13922
  • Akira Nagaoka, Hiroaki Takehara, Akiko Hayashi-Takagi, Jun Noguchi, Kazuhiko Ishii, Fukutoshi Shirai, Sho Yagishita, Takanori Akagi, Takanori Ichiki, Haruo Kasai. Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo. SCIENTIFIC REPORTS. 2016. 6. 26651
  • Noguchi J, Hayama T, Watanabe S, Ucar H, Yagishita S, Takahashi N, Kasai H. State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines. Scientific Reports. 2016. 6. 32897-32897
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MISC (22)：
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Patents (3)：
  • アポトーシス関連タンパク質
  • 筋萎縮性側索硬化症に関連する蛋白p53、その遺伝子及びその利用
  • 可溶性Fas抗原の免疫学的測定方法及びその測定用キット
Books (4)：
  • 樹状突起スパイン
    2020
  • 2光子顕微鏡
    2020
  • ケイジド化合物
    2018
  • 樹状突起スパイン
    2017
Lectures and oral presentations  (12)：
  • In vivo two-photon microscopy analysis of dendritic spines and axonal boutons in a marmoset autism model prefrontal cortex.
    (2021)
  • マーモセット自閉症モデル大脳皮質樹状突起スパインのin vivo2光子顕微鏡観察
    (第42回 日本分子生物学会年会)
  • バルプロ酸誘発性自閉症モデルマーモセットにおけるシナプス構造と機能の生後発達.
    (第42回日本神経科学大会、第62回日本神経化学学会大会)
  • 自閉症モデルマーモセット大脳皮質樹状突起のin vivo2光子観察.
    (第42回日本神経科学大会、第62回日本神経化学学会大会)
  • Abnormalities in synaptic structure and function in valproate-induced autism model marmosets.
    (第96回 日本生理学会大会(FAOPS2019合同開催))
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Professional career (1)：
  • 博士(理学) (総合研究大学院大学)
Association Membership(s) (2)：
THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE JAPAN NEUROSCIENCE SOCIETY
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