Rchr

J-GLOBAL ID：200901096314072885 Update date: Apr. 10, 2024

Motohashi Shinichiro

モトハシシンイチロウ | Motohashi Shinichiro

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.m.chiba-u.ac.jp/dept/medical-immunology/

Research field (1)： Immunology

Research keywords (4)：腫瘍免疫学 , 免疫学 , cancer immunology , 免疫療法

Research theme for competitive and other funds (29)：

2023 - 2026 HER2/CD3二重特異性抗体を用いたNKT細胞療法による肺癌免疫治療の検討
2022 - 2025 膠芽腫微小環境の理解に基づくNKT細胞標的治療の開発
2021 - 2024 Establishment of standard precision diagnosis methodology for lung cancer surgery using respiratory endoscopy technology.
2021 - 2024 幹細胞様CD8T細胞を起点とする腫瘍内T細胞分化の理解に基づくがん免疫療法の開発
2020 - 2023 NK細胞のアジュバント効果を利用したNKT細胞療法による肺癌免疫治療の検討

2013 - 2023 NKT細胞再生によるがん免疫治療技術開発拠点

2017 - 2022 Development of a Targeted T Cell Epitope Search System in Lung Cancer Patients Responding to Immunotherapy.

2019 - 2022 再発・進行頭頸部がん患者を対象としたiPS-NKT細胞動注療法に関する第1相試験

2018 - 2021 Induction of persistent lung transplant tolerance by IL-2 complex-stimulated regulatory T cells: a study for the clinical application

2018 - 2021 Development of new cancer immunotherapy that targets the CD69-Myl9/12 system

2018 - 2021 NKT cell-targeted cancer immunotherapy based on the comprehension of anti-tumor immune response in the lung cancer microenvironment

2017 - 2020 Development of diagnosis and treatment system using respiratory endoscopy to promote precision medicine

2017 - 2019 Research and development of NKT cell therapy in combination with antibody therapy in tumor and lymphocyte co-culture model

2017 - 2019 Genetic Profiling in murine orthotopic lung transplantation model of chronic lung allograft dysfunction

2017 - 2019 唾液腺がんに対するCAR T細胞とNKT細胞の併用療法に関する橋渡し研究

2016 - 2018 マウス肺移植モデルによる慢性拒絶反応の早期診断及び治療法の開発

2014 - 2017 Development of a novel combination immunotherapy with NKT cells and antibody therapy

2012 - 2017 Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosa

2014 - 2016 The production of the tumor antigen-specific TCR transduced human iNKT cells.

2012 - 2016 非小細胞肺癌に対するNKT細胞を用いた免疫細胞治療の開発研究

2013 - 2015 Research and development of combination therapy using iNKT cells and an anti-GD2 antibody toward neuroblastoma

2012 - 2015 Expression and functional characterization of cancer-type organic anion transporting polypeptide 1B3 in human lung and colon cancer

2012 - 2015 Anti-tumor effector mechanisms of activated NKT cells in the tumor microenvironment for novel NKT cell-based immunotherapy

2011 - 2013 Development of a novel therapeutic approach for pediatric malignant solid tumors using NKT cell-mediated immune system

2009 - 2011 Invariant NKT cell-target immunotherapy for non-smallc cell lung cancer

2007 - 2009 NKT cell-based immunotherapy for lung cancer

2005 - 2006 The strategy based on gene expression profiling using microarray for tailor-made treatment in patients with lung cancer

2003 - 2006 Clinical application of NKT cell immune system for lung cancer

1999 - 2002 A immunotherapy for primary non small cell lung cancer with Vα24 NKT cells

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Papers (133)：

Mariko Takami, Takahiro Aoki, Katsuhiro Nishimura, Hidekazu Tanaka, Atsushi Onodera, Shinichiro Motohashi. Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner. Cancer research communications. 2024. 4. 2. 446-459
Hiroki Matsumoto, Hidemi Suzuki, Takahiro Yamanaka, Taisuke Kaiho, Atsushi Hata, Terunaga Inage, Takamasa Ito, Toshiko Kamata, Kazuhisa Tanaka, Yuichi Sakairi, et al. Anti-CD20 Antibody and Calcineurin Inhibitor Combination Therapy Effectively Suppresses Antibody-Mediated Rejection in Murine Orthotopic Lung Transplantation. Life (Basel, Switzerland). 2023. 13. 10
飯沼智久, 本橋新一郎. 【細胞医薬という新しい創薬モダリティ】iPS細胞由来NKT細胞を用いた細胞療法の開発. 炎症と免疫. 2023. 31. 4. 302-305
Ryo Koyama-Nasu, Motoko Y Kimura, Masahiro Kiuchi, Ami Aoki, Yangsong Wang, Yukiyoshi Mita, Ichita Hasegawa, Yukihiro Endo, Atsushi Onodera, Kiyoshi Hirahara, et al. CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes. Cancer immunology research. 2023
Takahiro Aoki, Shinichiro Motohashi, Haruhiko Koseki. Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy. Inflammation and regeneration. 2023. 43. 1. 27-27

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MISC (199)：

青木孝浩, 本橋新一郎. 他家NKT 細胞を用いた免疫細胞療法の開発. 癌と化学療法. 2023. 50. 5. 584-588
松本寛樹, 鈴木秀海, 佐藤祐太朗, 祖父江晃向, 中山浩介, 山中崇寛, 由佐城太郎, 太枝帆高, 西井開, 伊藤祐輝, et al. マウス肺移植モデルでの抗CD20抗体の効果. 千葉医学. 2023. 99. 1
小野寺淳, 本橋新一郎. シングルセル解析. 耳鼻咽喉科. 2022. 2. 5. 666-671
青木孝浩, 本橋新一郎. iPS細胞由来NKT細胞を利用したがん免疫療法. Medical Technology. 2022. 50. 11. 1164-1166
石井絢菜, 髙見真理子, 本橋新一郎. 自然免疫を担うT細胞とB細胞 iNKT細胞. 臨床検査. 2022. 66. 5. 602-607

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Patents (2)：

NKT細胞活性化医薬組成物、その製造方法、及び抗原提示細胞の保存方法
NKT細胞リガンドをパルスした抗原提示細胞による抗腫瘍療法の有効性の予測方法

Books (13)：

必修!腫瘍免疫学 (北野滋久編集)
金原出版 2022 ISBN:9784307102087
がん免疫ペディア (吉村清編集)
羊土社 2022 ISBN:9784758121194
Chronic Inflammation (Editors: Masayuki Miyasaka, Kiyoshi Takatsu)
Springer 2016 ISBN:9784431560661
Immunotherapy of Cancer (Editor: Yoshiyuki Yamaguchi)
Springer 2016 ISBN:9784431550303
がんと免疫 (坂口志文,西川博嘉編集)
2015 ISBN:9784525134716

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Lectures and oral presentations (187)：

iPS 細胞を用いたがん免疫細胞療法
(第11回JAPSAM PRP・幹細胞研究会 2022)
Alpha-galactosylceramide-loaded antigen-presenting cells induce direct cytotoxicity and adjuvant effects of induced pluripotent stem cell-derived natural killer T cells
(第51回日本免疫学会学術集会 2022)
Anti-NKT cell antibody treatment enhances anti-tumor activity of NKT cells toward CD1d (-) tumors in a CD32 dependent manner
(第51回日本免疫学会学術集会 2022)
Blockade of aryl hydrocarbon receptor (AhR) signaling enhances anti-tumor efficacy of iNKT cell-based immunotherapy
(第51回日本免疫学会学術集会 2022)
Clinical application of NKT cells to cancer immunotherapy
(Korean Association for Lung Cancer International Conference 2022 2022)

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Education (2)：

1998 - 2002 Chiba University Graduate School of Medicine
1987 - 1993 Chiba University School of Medicine

Professional career (1)：

Doctor (Chiba University)

Work history (7)：

2020/04 - 現在 Chiba University
2020/04 - 現在千葉大学再生治療学研究センターセンター長
2013/04 - 現在 Chiba University
2007/04 - 2013/03 千葉大学大学院医学研究院免疫細胞医学准教授
2010/02 - 2010/05 JSPS優秀若手研究者海外派遣事業 Visiting Scholar

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Awards (3)：

2018/03 - 千葉大学平成29年度千葉大学優秀発明賞「NKT細胞活性化医薬組成物、その製造方法、及び抗原提示細胞の保存方法」
2011 - ゐのはな同窓会第16回ゐのはな同窓会賞学術賞「NKT細胞を用いたがん免疫細胞治療の開発研究」
2011 - 千葉医学会第3回千葉医学会賞

Association Membership(s) (7)：

日本免疫学会 , 日本再生医療学会 , 日本肺癌学会 , 日本呼吸器外科学会 , 日本外科学会 , 日本がん免疫学会 , 日本癌学会

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