Noritaka Hashii

ハシイノリタカ | Noritaka Hashii

Affiliation and department：
Homepage URL (1)： http://www.nihs.go.jp/index-j.html

Research field (6)： Pharmacology , Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development , Structural biochemistry , Biochemistry , Analytical chemistry

Research keywords (7)：包括脳ネットワーク , 高次構造 , 糖タンパク質 , プロテオミクス , グライコミクス , 質量分析 , 糖鎖

Research theme for competitive and other funds (9)：

2021 - 2024 MAPPs解析によるFcRn親和性の変化が抗原提示に及ぼす影響の解明
2017 - 2019 HLAの関与する解熱鎮痛薬誘因性重症薬疹の初期発症メカニズムの解明
2015 - 2018 Basic research on neonatal Fc receptor (FcRn) affinity to establish half-life extension technology of therapeutic antibodies
2015 - 2018 Development of analytical method for glycoprotein-glycan interaction by hydrogen/deuterium exchange mass spectrometry
2012 - 2014 水素/重水素交換反応及び質量分析法による糖タンパク質の高次構造解析技術の開発

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Papers (88)：

Rin Miyajima, Hitomi Manaka, Tatsuya Honda, Noritaka Hashii, Masato Suzuki, Masahiro Komeno, Koichi Takao, Akiko Ishii-Watabe, Kazuei Igarashi, Toshihiko Toida, et al. Intracellular polyamine depletion induces N-linked galactosylation of the monoclonal antibody produced by CHO DP-12 cells. Journal of Biotechnology. 2023. 378. 1-10
SHIBATA Hiroko, KIYOSHI Masato, NAKAKIDO Makoto, ITO Yuji, NISHIKAWA Atsushi, HASHII Noritaka, TADA Minoru, TSUMOTO Kouhei, ISHII-WATABE Akiko. Current situation and issues for stability prediction of biopharmaceuticals. PDA Journal of GMP and Validation in Japan. 2023. 25. 1. 1-9
Keisuke Tsuchiya, Masato Kiyoshi, Noritaka Hashii, Minami Fujita, Takashi Kurohara, Akiko Ishii-Watabe, Kiyoshi Fukuhara, Takashi Misawa, Yosuke Demizu. Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling. Bioorganic & medicinal chemistry. 2022. 73. 117021-117021
Noritaka Hashii, Michiko Tajiri, Akiko Ishii-Watabe. [Quality Evaluation of Therapeutic Antibodies by Multi-attribute Method]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2022. 142. 7. 731-744
Ryo Shinnakasu, Shuhei Sakakibara, Hiromi Yamamoto, Po-Hung Wang, Saya Moriyama, Nicolas Sax, Chikako Ono, Atsushi Yamanaka, Yu Adachi, Taishi Onodera, et al. Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses. The Journal of experimental medicine. 2021. 218. 12

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MISC (96)：

伊藤海結, 関根優莉奈, 正田卓司, 橋井則貴, 原園景, 石井明子, 井上英史, 出水庸介, 出水庸介. Development of fluorescent labeling reagents for glycoproteins. 日本薬学会年会要旨集(Web). 2023. 143rd
正田卓司, 橋井則貴, 原園景, 石井明子, 出水庸介. Development of fluorescent labeling reagents for glycoproteins. 日本糖質学会年会要旨集. 2023. 42nd
土屋圭輔, 土屋圭輔, 木吉真人, 橋井則貴, 藤田陽, 藤田陽, 石井明子, 福原潔, 三澤隆史, 出水庸介, et al. Development of helical peptides inhibiting Wnt/β-catenin signaling pathway. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)
真中瞳, 本田達也, 橋井則貴, 五十嵐一衛, 五十嵐一衛, 戸井田敏彦, 東恭平. 細胞内ポリアミン量の減少は小胞体ストレスとN-結合型糖鎖のガラクトシル化の亢進を引き起こす. 日本生化学会大会(Web). 2021. 94th
橋井則貴. Structural characterization of antibody-drug conjugate by liquid chromatography/mass spectrometry. Bio Clinica. 2021. 36. 6

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Patents (4)：

Professional career (1)：

薬学博士

Awards (1)：

2007/08 - 第27回日本糖質学会ポスター賞

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