Abe Masahiro

アベマサヒロ | Abe Masahiro

Affiliation and department：
Job title： Professor

Research field (1)： Hematology and oncology

Research keywords (2)：血液内科学 , hematology

Research theme for competitive and other funds (27)：

2022 - 2025 分泌蛋白の網羅解析による骨髄腫の未知の病態形成/予後因子の探索と新規治療の開発
2021 - 2025 骨破壊腫瘍進展と骨病変形成における細胞内情報伝達系の恒常的活性化機構の解明と制御
2021 - 2024 加齢性サルコペニアへの炎症性サイトカインの関与とTAK1阻害による治療法の開発
2018 - 2022 The roles of the TAK1-Pim-2 pathway in drug resistance and bone destruction in multiple myeloma and development of novel agents to conquer them
2014 - 2019 Cancer Diagnosis and Prognosis Assistance Based on Multidisciplinary Computational Anatomy

2014 - 2017 Mechanisms of myeloma growth in bone marrow microenvironment and development of novel therapeutic options for myeloma

2013 - 2016 Elucidation of molecular mechanism of the regulation of skeletal homeostasis, and development of new therapeutic approaches against skeletal disorders

2009 - 2014 Computer-Aided Diagnosis Based on Computational Anatomical Models

2011 - 2013 Mechanisms of bone destruction and drug resistance in myeloma: a novel therapeutic strategy targeting a myeloma-bone marrow interaction

2008 - 2010 Relationships among skeletal, adipose and vasclar regulatory system, and elucidation of pathogensis caused by disturbances of these systems

2005 - 2007 Molecular mechanic sum of the regulation and dies regulation of bone homeostasis and Development of therapeutic approaches

2003 - 2004 Identification and clinical application of osteoclast-derived growth factors for myeloma

2000 - 2004 骨格系の制御に関わる転写因子と骨粗鬆症におけるその異常

2002 - 2003 Elucidation of signal transduction pathway via HM1.24 and application toward the treatment of hematological malignancies

2001 - 2003 Development of immunotherapy targeting neoplastic lymphocyte-specific antigen (2D7) against hematological malignancies

2001 - 2002 Roles for MIP-1α and β in the development of osteolytic lesions in multiple myeloma

1999 - 2001 Mechanism of signal transduction that regulates osteoclast differentiation and its abnormalities in bone distructive diseases

骨転移の治療法の開発

造血器腫瘍の治療法の開発

癌の骨転移

多発性骨髄腫の病態と治療

血液疾患に関する研究

treatment of bone metastasis

treatment of hematological malignancies

Cancer metastasis to bone

Biology and treatment of multiple myelomd

Study on blood disease

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Papers (2)：

Kenichi Tahara, Hiromi Koiso, Yo-Hei Osaki, Tomomi Sekigami, Akihiko Yokohama, Takayuki Saitoh, Norifumi Tsukamoto, Hirokazu Murakami, Masahiro Abe, Hiroshi Handa. Malignancy-Associated Hypercalcemia Related with Receptor Activator of NF-κB Ligand (RANKL) Expression in T-Cell Acute Lymphoblastic Leukemia. Acta haematologica. 2019. 141. 3. 135-137
Hanson Derek James, Nakamura Shingen, Amachi Ryota, Hiasa Masahiro, Oda Asuka, Tsuji Daisuke, Itoh Kohji, Harada Takeshi, Horikawa Kazuki, Teramachi Jumpei, et al. Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation. Oncotarget. 2015. Vol.6. No.32. 33568-33586

MISC (35)：

M. Abe, M. Hiasa, A. Oda, H. Amou, K. Takeuchi, O. Tanaka, S. Nakamura, H. Miki, K. Kagawa, K. Yata, et al. Bone Marrow Stromal Cells Up-regulate M-CSF Receptor in Monocytes to Disrupt Dendritic Cell Differentiation While Facilitating Osteoclastogenesis in Myeloma. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S301-S301
K. Takeuchi, M. Abe, M. Hiasa, O. Tanaka, S. Nakamura, H. Miki, K. Kagawa, K. Yata, T. Hashimoto, S. Ozaki, et al. TGF-beta Suppresses Adipocytic Differentiation and Enhances Accumulation of Stromal Cells in Myeloma Bone Lesions. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S189-S189
K. Takeuchi, M. Abe, A. Oda, H. Amou, M. Hiasa, O. Tanaka, S. Fujii, S. Nakamura, A. Mihara, H. Miki, et al. TGF-beta inhibition suppresses myeloma cell growth via enhancement of osteoblast differentiation. JOURNAL OF BONE AND MINERAL RESEARCH. 2007. 22. S295-S295
N Kimura, S Kawai, Y Kinoshita, T Ishiguro, Y Azuma, S Ozaki, M Abe, M Sugimoto, Y Hirata, T Orita, et al. L2D7 diabody bound to the alpha 2 domain of HLA class I efficiently induces caspase-independent cell death against malignant and activated lymphoid cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004. 325. 4. 1201-1209
M Abe, K Hiura, J Wilde, A Shioyasono, K Moriyama, T Hashimoto, S Kido, T Oshima, H Shibata, S Ozaki, et al. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. BLOOD. 2004. 104. 8. 2484-2491

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Books (1)：

Immunoassays for activin and follistatin : results in normal and diseased subjects. (共著)
Inhibin, activin, follistatin : recent advances and futureview 1997

Education (2)：

- 1959 The University of Tokushima Faculty of Medicine
- 1959 The University of Tokushima Faculty of Medicine

Professional career (1)：

(BLANK) (The University of Tokushima)

Awards (1)：

2001 - International Myeloma Foundation the Award in Akis Memory

Association Membership(s) (6)：

Japanese Society of Myeloma , 日本骨代謝学会 , 日本臨床免疫学会 , 日本内科学会 , 日本臨床血液学会 , 日本血液学会

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