Research field (2)：
Molecular biochemistry
, Medical biochemistry
Research keywords (7)：
Regenerative Medicine
, iPS Cell
, Mechanisms of Transcriptional Regulation
, Chromatin
, Gene Expression
, Transcription
, adipocyte
Research theme for competitive and other funds (18)：
2021 - 2024 Mechanistic analysis of somatic cell reprogramming using paused iPSCs
2017 - 2020 Reprogramming of cell morphology and functions by Klf4 during iPSC generation
2017 - 2018 A Tcl1-mediated method to generate iPSCs with reduced genomic mutations
2014 - 2017 A novel gene therapy by full-length coagulation factor VIII
2013 - 2016 Analysis of the transcription factor network during the early stage of iPSC production
2010 - 2013 Analysis of the components of a novel coactivator.the NF complex, and its regulatory mechanisms
2006 - 2007 新規コアクチベーターによる転写過程の包括的調節機構の解析
2006 - 2007 Analysis of regulatory mechanisms of chromatin phosphorylation by kinases
2005 - 2005 NF複合体によるc-fos遺伝子のクロマチン修飾と発現制御
2004 - 2005 Analysis of a novel coactivator that activates the c-fos gene
2002 - 2004 Involvement of mRNA capping enzyme in transcription initiation
2001 - 2001 P38MAPキナーゼを介した造血幹細胞の時系列分化の分子メカニズムの解明
2000 - 2000 発がん化防御に関わるXPBおよびXPD遺伝子における変異の分子病態
1999 - 2000 Role of protein phosphorylation in Myulating RNA polymerase II transcription
1997 - 2000 Molecular mechanisms of functional expression of transcription regulation factors through their interaction with coactivators or corepressors
Takumi Kishimoto, Ken Nishimura, Kana Morishita, Aya Fukuda, Yusaku Miyamae, Yutaro Kumagai, Kimio Sumaru, Mahito Nakanishi, Koji Hisatake, Masayuki Sano. An engineered ligand-responsive Csy4 endoribonuclease controls transgene expression from Sendai virus vectors. Journal of biological engineering. 2024. 18. 1. 9-9
Sekiguchi, Yuya, Fukuda, Aya, Nishimura, Ken, Hisatake, Koji. Engineering Critical Residues of SOX9 Discovers a Variant With Potent Capacity to Induce Chondrocytes. STEM CELLS. 2023. Epub
Burramsetty, Arun Kumar, Nishimura, Ken, Kishimoto, Takumi, Hamzah, Muhammad, Kuno, Akihiro, Fukuda, Aya, Hisatake, Koji. Locus-Specific Isolation of the Nanog Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022. 23. 23
Mayers, Thomas David, Mathis, Bryan J, Ho, C. Kiong, Morikawa, Kazuya, Maki, Naoki, Hisatake, Koji. Factors Affecting Undergraduate Medical Science Students’ Motivation to Study during the COVID-19 Pandemic. Education Sciences. 2022. 12. 9
Anh, Le Phuong Hoang, Nishimura, Ken, Kuno, Akihiro, Linh, Nguyen Thuy, Kato, Tetsuo, Ohtaka, Manami, Nakanishi, Mahito, Sugihara, Eiji, Sato, Taka-Aki, Hayashi, Yohei, et al. Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming. Stem cells (Dayton, Ohio). 2022. 40. 4. 397-410
Matsumoto Masahito, Kogawa Masakazu, Hisatake Koji, Atkins Gerald, Findlay David, Enoki Yuichiro, Sato Tsuyoshi, Wada Seiki, Fukuda Aya, Katayama Shigehiro, et al. Dual functions the role of Pax6 in the regulation of bone and glucose metabolism. JOURNAL OF BONE AND MINERAL RESEARCH. 2013. 28
Mechanism of histone H3 phosphorylation upon induction of c-fos gene transcription
Jikken Igaku, vol.25, No.10 Yodosha 2007
Histone methylation and transcriptional regulation
biochemistry The Japanese Biochemical Society 2007
Lectures and oral presentations (68)：
Discovery of a novel SOX9 mutant with potent capacity to induce chondrocytes
(The 36th Annual Meeting of the Japanese Society of Cartilage Metabolism)
Mechanistic analysis of chromosome-wide epigenetic change during iPSC generation using Klf4-dose dependent reprogramming system
(The 20th International Joint Mini-Symposium on Molecular and Cell Biology among KU-NTU-UT)
iPS細胞誘導過程において二相性の機能を有するE2F4の解析
(第45回日本分子生物学会年会)
Dual function of E2F4 on iPSC generation
(TGSW2022)
A dCas9 based method can identify novel regulators of Nanog and pluripotency
(ISSCR2022)
- 1985 Okayama University Medical School Faculty of Medicine
Work history (6)：
2011/10 - 現在 University of Tsukuba Faculty of Medicine
2006/01 - 2011/09 University of Tsukuba Graduate School of Comprehensive Human Sciences
2000/06 - 2005/12 Saitama Medical University Faculty of Medicine
1994/11 - 2000/05 Saitama Medical University Faculty of Medicine
1994/04 - 1994/10 ロックフェラー大学 ポストドクトラル アソシエート
1991/04 - 1994/03 ロックフェラー大学 ポストドクトラル フェロー
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Association Membership(s) (4)：
THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, American Society for Biochemistry and Molecular Biology
, THE JAPANESE BIOCHEMICAL SOCIETY
, The Molecular Biology Society of Japan
