Research theme for competitive and other funds (13):
2022 - 2025 Transcriptional regulation of angiogenesis and tissue differentiation in microenvironment
2022 - 2024 麻酔薬圧拮抗作用の実時間イメージング
2020 - 2024 Lymphatic transport of dietary flavonoids: elucidation of its driving force and physiological roles
2021 - 2022 転写因子Dach1によるリンパ節血管形成分子メカニズムの解明
2019 - 2022 転写因子 Dach1 による組織特異的な血管内皮細胞分化調節メカニズム
2016 - 2020 The mechanism underlying tumor inhibition by angiogenesis and immune cell recruitment
2012 - 2017 Characteristics and functions of stromal cells in secondary lymphoid tissues
2014 - 2016 アレルギー性皮膚炎予防を目的としたケモカイン受容体抑制ペプチドの開発
2013 - 2016 Analysis of the transcription factor crosstalk in high endothelial venule formation
2009 - 2014 Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states
2009 - 2014 Analysis of the conformational transitions and functional modifications in membrane proteins
2010 - 2012 Understanding of the mechanism underlying the tissue-specific differentiation of high endothelial venule endothelial cells
Megumi Miyamoto, Yuki Kawato, Ryonosuke Fujie, Kaoru Kurowarabe, Kakeru Fujiwara, Reika Nobusawa, Ryota Hayashi, Kei Iida, Izumi Ohigashi, Haruko Hayasaka. CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth. Cancer Science. 2023. 114. 9. 3509-3522
Masako Sato, Kazuhiko Matsuo, Yoko Susami, Ayaka Yamashita, Haruko Hayasaka, Yuta Hara, Keiji Nishiwaki, Naoki Oiso, Akira Kawada, Atsushi Otsuka, et al. A CCR4 antagonist attenuates atopic dermatitis-like skin inflammation by inhibiting the recruitment and expansion of Th2 cells and Th17 cells. International immunology. 2023. 35. 9. 437-446
Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. Cell death & disease. 2023. 14. 4. 256-256
Ryota Hayashi, Hayato Nakatani, Hinami Kawahata, Ryonosuke Fujie, Kaoru Kurowarabe, Haruko Hayasaka. Firefly luciferase-based chronological measurement of effector CD8+ T-cell activity using a multi-chamber luminometer. Bioanalysis. 2023. 14. 1413-1421
Experimental strategy for multi-sample screening of CCR7 activating molecules
(日本分子生物学会年会プログラム・要旨集(Web) 2023)
Immunosuppressive effects of flavonoid metabolites in mesenteric lymph nodes
(日本分子生物学会年会プログラム・要旨集(Web) 2023)
Chemokine CCL28-mediated antitumor immunity against a murine melanoma
(日本薬学会年会要旨集(Web) 2023)
CCR4 antagonist ameliorated atopi dermatitis by inhibiting infiltration and expansion of CCR4-expressing Th2 cells and Th17 cells in mice
(日本薬学会年会要旨集(Web) 2023)