Rchr

J-GLOBAL ID：200901097884197254 Update date: Jan. 31, 2024

Kido Hiroshi

キドヒロシ | Kido Hiroshi

Affiliation and department：
Job title： Professor

Research field (3)： Pathobiochemistry , Medical biochemistry , Functional biochemistry

Research keywords (8)：アレルギー , 分子シヤペロン , インフルエンザウイルス , プロテアーゼ , Allergy , Molecular chaperone , Influenza virus , Protease

Research theme for competitive and other funds (87)：

2017 - 2019 Allergy research prospect with new paradigm open up by the new sensitive allergen microarray
2016 - 2019 Study on the pathogenesis of severe influenza virus infection associated with cytokine storm and its effective treatment options
2015 - 2017 Discovery of antigen-specific low affinity IgE in cord blood and the mechanisms of affinity maturation after birth for prevention of allergy
2013 - 2015 Screening of Flu Alarmin biomarkers of severe influenza virus infection and their confirmation in animal model
2012 - 2015 The application to cancer vaccine of SSF that mimics pulmonary surfactant

2012 - 2015 Pathogenicity of multiple organ failure induced by seasonal and highly pathogenic avian influenza virus infection and its therapeutic options

2011 - 2013 The analysis of host response determining the severe influenza and HIV infection.

2011 - 2012 Studies on real-time biomarker of illness severity inthe patients of critical illness and development of the diagnosis machine

2009 - 2011 Development of new therapeutics for a highly pathogenic influenza virus infection by inhibition of virus entry and multiplication

2009 - 2010 乳幼児食物アレルギーの診断と予防を可能にする臍帯血高感度診断デバイスの開発研究

2008 - 2010 The chemical biology of low side effects compound in anti-fever drugs, which is derived from the analysis about fatal function by diclofenac.

2007 - 2008 食物アレルギーを血液と唾液から総合的に診断する新規ハイスループットデバイスの開発

2006 - 2006 ハイスループット食物アレルゲンエピトープ解析ダイヤモンドコーティングチップの開発

2005 - 2006 The role of anti-apoptotic factor 14-3-3 in HIV-1-associated dementia (HAD) pathology : The implication for the therapy

2003 - 2004 Mechanism of encephalitis after influenza virus infection based on defect of β-oxidation in liver

2002 - 2003 The relationship between a molecular chaperone and protease : The discovery of NDP kinase like activity of a chaperone, and degeneration diseases.

2001 - 2003 Development of new influenza virus treatments based an the findings of triggering proteases for influenza virus entry into the cells and on the findings of protease-activating receptors

2000 - 2003 Development of an immunocontraceptive DNA vaccine using sperm

2001 - 2002 Functional analysis of substrate-aggregation inhibition and unfoldase activities in the 20S proteasome

2001 - 2002 Molecular chaperone activity of the 20S proteasome : Inhibitory activity of the substrate protein aggregation and unflodase activity

2000 - 2002 The basic study concerning the high pregnancy rate by in vitro fertilization-embryo transfer treatment in infertile women with antisperm antibody

2000 - 2002 Pathophysiological role of ET-1(1-31) on the inflammatory diseases.

2002 - 食物アレルギー蛋白チップ

2002 - 蛋白チップの開発研究

2002 - Protein chip for food allergy

2002 - Development of Protein chip for Proteomics

2001 - 2001 新規生理活性物質・エンドセリン(1-31)の意外な顆粒球・好酸球ケモカイン作用

2001 - 2001 高感度赤外線蛍光内視鏡を用いた微小癌診断法の開発

2001 - 2001 生体内新規鍵物質エンドセリン(1-31)の生理機能:ケモカイン作用と未梢循環制御

2000 - 2000 ATP依存性立体構造変異蛋白群に内在するシャペロン型NDPK活性の発見と変異機序

2000 - 2000 赤外線蛍光内視鏡を用いた微小癌診断法の開発

2000 - 2000 癌細胞膜上のMMP9前躯体新規活性化機構の発見と癌細胞浸潤機序の解析

2000 - 2000 新規生理活性物質エンドセリン(1-31)の発見とその意外な新生理機能

1999 - 2000 Mutations of the core gene sequence of HCV from patients with hepatocellular carcinoma in China and Japan

1999 - 2000 The studies on the sugar chain structures of rat cathepsin J (C) and its functions.

1999 - 2000 Discovery of chaperone-type nucleoside diphosphate kinase, a novel function of molecular chaperone proteins, and role of the activity in proteolysis

1999 - 2000 Discovery of chaperone-type nucleoside diphosphate kinase activity in Hsp70 and proteasome and its pathophysiological function in these proteins

1998 - 2000 Discovery of the potentiating proteases for influenza virus infection and their inhibitors as defensive compounds

1997 - 2000 Hormonal regulation of production and activation of immunoglobulin binding factor.

1999 - 1999 新規生理活性物質エンドセリン(1-31)の発見と新生理機能の解析

1998 - 1999 Role of newly discovered endothelin-1(1-31) on renal injury

1997 - 1999 Regulation and Physiological Roles of Human Tryptase in the Secretary Granules of Mast Cells

1996 - 1999 Mechanism of Selective Degradation of Proteins

1998 - 1998 新しい分子シャペロン蛋白質機能、NDP キナーゼ活性の発見と作用機構の解析

1998 - 1998 癌転移・浸潤にかかわる膜結合型MMP前駆体活性化酵素の発見と作用機序の解析

1997 - 1998 Novel bioactive endothelins (1-31) produced by chymase and their physiological functions

1997 - 1998 Medical use of protease inhibitors for virus infection

1996 - 1998 Development of novel diagnosis method for minutecancer by infrared fluorescence endoscopy using fluorescence-emitting antibody by infrared ray excitation.

1997 - 1997 新しい分子シャペロン蛋白機能の発見とこれによる基質との動的相互作用

1996 - 1997 IDENTIFICATION OF NEW GLOMERULAR PROGRESSION FACTORS USING MONOCLONAL ANTIBODY

1995 - 1997 エイズの病態と制御に関する基礎研究柱1.HIVの複製機構

1996 - 1996 キマ-ゼの形成する新しいエンドセリン誘導体の血管と気管支平滑筋収縮作用の解析

1995 - 1996 Virus activation by tryptase and its inhibition in vivo

1995 - 1995 ウイルスと細胞との膜融合を誘発する細胞性プロテアーゼの発見とその制御因子の解析

1995 - 1995 バイオモジュレーターとしてのプロテアーゼ

1995 - 1995 細胞増殖の制御とプロテアーゼ

1995 - 1995 B型肝炎ウイルスX蛋白質と結合する肝細胞内プロテアーゼの機能変化と発癌機序の解析

1993 - 1995 Isolation of the cellular protease that determines infectious tropism of influenza virus in human and inhibition of the infection by the protease inhibitor from human bronchial lavage

1994 - 1994 細胞増殖の制御とプロテアーゼ

1994 - 1994 B型肝炎ウイルスX蛋白質と結合する肝細胞内プロテアーゼの機能変化と発癌機序の解析

1994 - 1994 HIVのTリンパ球への結合と膜融合に関与するT細胞内プロテアーゼの作用機序

1993 - 1993 インフルエンザウイルスの感染性を決定する宿主細胞プロテアーゼの発見と作用機序

1993 - 1993 エイズウイルスの感染性と複製に関与するT細胞内プロテアーゼ群の作用機序の解析

1993 - 1993 細胞増殖の制御とプロテアーゼ

1992 - 1992 糖鎖構造をモデルにしたカテプシンLの細胞内選別輸送の分子機構

1992 - 1992 Tリンパ球へのエイズウイルス感染におけるトリプシン型ブロテアーゼ群関与の分子機構

1991 - 1992 Purification of processing protease for retroviral envelope glycoprotein and role of it in the process of retroviral infection

1991 - 1991 Tリンパ球へのエイズウイルス感染機構におけるトリプシン型プロテア-ゼの関与

1991 - 1991 レトロウイルス外膜蛋白活性化プロテア-ゼの発見と、その阻害剤による感染阻止

1990 - 1991 An approach for development of new drugs for AIDS which inhibit the novel receptor for AIDS virus

1990 - 1991 A novel membrane-bound serine protease in human T4^+-lymphocyte -possible receptor for HIV gp120-

1990 - 1990 アルツハイマ-病アミロイド前駆蛋白の局在ならびに生物機能

1990 - 1990 Tリンパ球へのエイズウイルス感染機構におけるトリプシン型プロテア-ゼの関与

1990 - ウイルス感染と生態防御(インフルエンザウイルス、HIV-1)

1990 - Virus injection and host-defense system

1989 - 1989 Tリンパ球へのエイズウイルス感染機構におけるトリプシン型プロテア-ゼの関与

1989 - 1989 グルココルチコイド作用増強物質によるリンパ性白血病の新治療法の開発

1989 - 1989 グルココルチコイド作用発現におけるプロテインキナ-ゼCの役割

1988 - 1988 グルココルチコイド作用増強物質によるリンパ性白血病の新治療法の開発

1987 - 1988 Synthesis and large production of glucocorticoid action enhancers and development of new steroid therapy.

1987 - 1988 Effects of chymase on limited proteolysis and activation of protein kinase on the mechanism of degranulation from mast cells

1987 - 1987 グルココルチコイド作用増強物質によるリンパ性白血病の新治療法の開発

1986 - 1986 γ-グルタミントランスペプチダーゼのProcessing Proteaseの追求

1986 - 1986 肥満細胞のヒスタミン顆粒に局在するキマーゼとトリプターゼの細胞生理的役割

1977 - 細胞内タンパク質分解機構の解明とその病態への応用

1977 - Studies on intracellular proteolysis and their medical

インフルエンザの粘膜ワクチン開発

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Papers (182)：

Etsuhisa Takahashi, Takako Sawabuchi, Tetsuya Homma, Yosuke Fukuda, Hironori Sagara, Takeshi Kinjo, Kaori Fujita, Shigeru Suga, Takashi Kimoto, Satoko Sakai, et al. Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity. Viruses. 2023. 15. 8. 1662-1662
Masaki Shoji, Kenta Ichihashi, Nongluk Sriwilaijaroen, Haruka Mayumi, Shinji Morikane, Etsuhisa Takahashi, Hiroshi Kido, Yasuo Suzuki, Kazuyoshi Takeda, Takashi Kuzuhara. Anti-influenza activity of povidone-iodine-integrated materials. Biological & pharmaceutical bulletin. 2023
Takashi Kimoto, Satoko Sakai, Keiko Kameda, Ryoko Morita, Etsuhisa Takahashi, Yasuo Shinohara, Hiroshi Kido. Induction of systemic, mucosal, and cellular immunity against SARS-CoV-2 in mice vaccinated by trans-airway with a S1 protein combined with a pulmonary surfactant-derived adjuvant SF-10. Influenza and Other Respiratory Viruses. 2023. 17. 3
Takashi Kimoto, Satoko Sakai, Keiko Kameda, Ryoko Morita, Etsuhisa Takahashi, Yasuo Shinohara, Hiroshi Kido. Induction of systemic, mucosal, and cellular immunity against SARS-CoV-2 in mice vaccinated by trans-airway with a S1 protein combined with a pulmonary surfactant-derived adjuvant SF-10. Influenza and Other Respiratory Viruses. 2023. 17. 3
Keiko Kameda, Etsuhisa Takahashi, Takashi Kimoto, Ryoko Morita, Satoko Sakai, Mizuho Nagao, Takao Fujisawa, Hiroshi Kido. A Murine Model of Food Allergy by Epicutaneous Adjuvant-Free Allergen Sensitization Followed by Oral Allergen Challenge Combined with Aspirin for Enhanced Detection of Hypersensitivity Manifestations and Immunotherapy Monitoring. Nutrients. 2023. 15. 3

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MISC (314)：

齋藤麻耶子, 佐藤未織, 山本貴和子, 多田仁美, 苛原誠, 松本健治, 朴慶純, 木戸博, 大矢幸弘. 加熱鶏卵アレルギー児におけるIgE抗体親和性の診断能についての検討. 日本小児アレルギー学会誌(Web). 2020. 34. 4
木本貴士, 木戸博. 肺サーファクタント由来人工合成粘膜アジュバントSF-10を利用した経鼻接種インフルエンザワクチン開発とその最新の知見. 日本肺サーファクタント・界面医学会雑誌. 2018. 49. 8-12
木本貴士, 木戸博. 【予防接種アップグレード】その他生体成分粘膜アジュバントSF-10混合経鼻インフルエンザワクチンの展望. 小児内科. 2018. 50. 8. 1301-1304
木本貴士, 木戸博. 【予防接種アップグレード】その他生体成分粘膜アジュバントSF-10混合経鼻インフルエンザワクチンの展望. 小児内科. 2018. 50. 8. 1301-1304
Chida J, Kido H, Sakaguchi S. Development of novel therapeutics targeting host molecules for influenza. Bio Clinica. 2018. 256. 33. 52-55

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Patents (7)：

免疫寛容誘導剤及びアレルギー性疾患の治療又は予防剤
抗インフルエンザ薬による獲得免疫機能低下抑制用組成物およびその製造方法
アレルギー発症リスクを予測するためのデータを収集する方法
粘膜ワクチン
合成ペプチドを含有する抗原薬物ビークルとこれを用いる粘膜ワクチン

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Books (1)：

Protease activity of influenza virus RNA polymerase PA subunit
International Congress Series 1219, 479-485 (2001) 2001

Works (2)：

蛋白チップの開発研究
2002 -
Development of Protein chip
2002 -

Education (4)：

- 1977 The University of Tokushima
- 1977 The University of Tokushima Graduate School of Medicine
- 1973 Hirosaki University School of Medicine
- 1973 Hirosaki University School of Medicine

Professional career (1)：

Ph.D (The University of Tokushima)

Work history (6)：

1991 - 1995 The University of Tokushima
1991 - 1995 Associate Professor of Tokushima University
1995 - - 徳島大学教授
1995 - - Professor of Tokushima University
1981 - 1991 The University of Tokushima

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Committee career (6)：

2003/07 - 現在日本病態プロテアーゼ学会理事、評議員
- 現在日本界面医学界理事、評議員
2009/07 - 2011/08 International Proteolysis Society President
2002/07 - 2005/08 International Proteolysis Society Vice President
2002 - International Proteolysis Society Vice President

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Association Membership(s) (14)：

国際プロテオリーシス学会 , 日本分子生物学会 , 日本生化学会 , 日本癌学会 , 日本エイズ医学会 , 日本ウイルス学会 , 日本アレルギー学会 , International Proteolysis Society , The Molecular Biology Society of Japan , The Japanese Society for Virology , Japanese Society of Allergology , Japanese Society for AIDS Research , Japanese Cancer Association , Japanese Biochemical Society

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