Rchr
J-GLOBAL ID:200901098095256188   Update date: Jan. 31, 2024

Ueda Kazumitsu

ウエダ カズミツ | Ueda Kazumitsu
Affiliation and department:
Job title: Professor,Professor
Homepage URL  (1): https://www.icems.kyoto-u.ac.jp/
Research field  (2): Applied molecular and cellular biology ,  Molecular biology
Research keywords  (6): 分子生物学 ,  癌化学療法 ,  応用分子細胞生物学 ,  Molecular Biology ,  Cancer Chemotherapy ,  Applied Molecular Cell Biology
Research theme for competitive and other funds  (49):
  • 2023 - 2026 ABCA1による高密度リポ蛋白質(HDL)産生メカニズムの可視化
  • 2018 - 2023 Uncovering the secrets of lipid-transporting ABC proteins
  • 2013 - 2018 Molecular mechanism of ABC proteins involved in cholesterol homeostasis
  • 2013 - 2014 HDL(善玉コレステロール)形成の鍵をにぎるABC蛋白質の作用機構解明
  • 2008 - 2012 Physiological substrates and functions of ABC proteins involved in lipid transport
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Papers (293):
  • Hiroshi Tachibana, Kodai Minoura, Tomohiro Omachi, Kohjiro Nagao, Takafumi Ichikawa, Yasuhisa Kimura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Kazumitsu Ueda, et al. The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains. Journal of cell science. 2023. 136. 16
  • Ryota Futamata, Masato Kinoshita, Katsueki Ogiwara, Noriyuki Kioka, Kazumitsu Ueda. Cholesterol accumulation in ovarian follicles causes ovulation defects in Abca1a Japanese medaka (Oryzias latipes). Heliyon. 2023
  • Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda. ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs. FEBS letters. 2021. 595. 6. 707-716
  • Ryota Futamata, Noriyuki Kioka, Kazumitsu Ueda. Live Cell FRET Analysis of the Conformational Changes of Human P-glycoprotein. Bio-protocol. 2021. 11. 4. e3930
  • Mitsuhiro Nakato, Naoko Shiranaga, Maiko Tomioka, Hitomi Watanabe, Junko Kurisu, Mineko Kengaku, Naoko Komura, Hiromune Ando, Yasuhisa Kimura, Noriyuki Kioka, et al. ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking. Journal of Biological Chemistry. 2021. 296. 100166-100166
more...
MISC (181):
  • 小笠原史彦, 岡本雄介, 木村泰久, 木岡紀幸, 木岡紀幸, 植田和光. C-terminus of ABCA1 separately regulates cholesterol-flopping activity and HDL-generating activity. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 小段篤史, 光岡薫, 木村泰久, 木岡紀幸, 植田和光. Expression and purification of a lipid efflux ABC protein aiming for Cryo-EM analysis. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 岩村紗花, 木岡紀幸, 植田和光, 木村泰久. Thermodynamic analysis of the enhancement of substrate-dependent ATPase activity of MDR1 by cholesterol. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 坂田和樹, 木岡紀幸, 植田和光, 木村泰久. The analysis of the sterol specificity of human ABCA1 using liposomes. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 立花大, 箕浦広大, 長尾耕治郎, 木村泰久, 植田和光, 木岡紀幸. Comparative analysis of the lipid composition of focal adhesion membrane and plasma membrane. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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Books (10):
  • ABCトランスポーター-生体防御のABC-遺伝子から疾患まで.
    診断と治療社, 2002
  • MDR1遺伝子を介した多剤耐性.In癌の薬剤耐性とその克服-基礎と臨床,大沼尚夫,and竹村譲eds.
    宇宙堂八木書店,/,63-72 2001
  • ガン細胞の薬剤耐性機構
    In動物細胞細胞工学ハンドブック:朝倉書店, 2001
  • Cell volume regulation. The molecular mechanism and volume sensing machinery. (共著)
    Volume sesor anion channel., 1998
  • How does P-gp recognize its substrates? (共著)
    Seminars in Cancer Biology, 1997
more...
Education (4):
  • - 1982 Kyoto University
  • - 1982 Kyoto University Graduate School, Division of Agriculture
  • - 1978 Kyoto University Faculty of Agriculture
  • - 1978 Kyoto University Faculty of Agriculture
Professional career (2):
  • Doctor of Agriculture (Kyoto University)
  • Master of Agriculture (Kyoto University)
Committee career (6):
  • 2015 - 2017 日本農芸化学会 会長
  • 2013 - 2015 日本農芸化学会 副会長
  • 2008 - 2010 日本生化学会 常務理事
  • 2003 - 日本農芸化学会 関西支部評議員
  • 日本生化学会 評議員
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Awards (3):
  • 2017 - 科学技術分野の文部科学大臣表彰科学技術賞
  • 2010/03 - 日本農芸化学会 日本農芸化学会賞
  • 1992 - 日本農芸化学会奨励賞
Association Membership(s) (5):
日本分子生物学会 ,  米国癌学会 (AMERICAN ASSOCIATION FOR CANCER RESEARCH) ,  日本生化学会 ,  日本癌学会 ,  日本農芸化学会
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