Rchr
J-GLOBAL ID：200901098732915840
Update date: Mar. 20, 2024
Oshima Hiroko
オオシマ ヒロコ | Oshima Hiroko
Affiliation and department：
Homepage URL (1)：
http://www.kanazawa-u.ac.jp/~ganken/oshima/index.html
Research field (1)：
Tumor biology
Research keywords (4)：
転移・悪性化
, 炎症と発がん
, 消化器がん
, マウスモデル
Research theme for competitive and other funds (20)：
- 2023 - 2026 胆管がん発生における線維性微小環境制御機構の探索
- 2022 - 2026 自然免疫反応とCOX2/PGE2経路による転移微小環境の構築
- 2019 - 2022 炎症性・線維性微小環境による大腸がん転移促進機構の解明
- 2016 - 2019 Establishment of novel gastric cancer mouse models
- 2015 - 2019 Analysis on colon cancer malignant progression using novel mouse models
- 2013 - 2016 SOX17 suppression and inflammation in malignant cancer progression
- 2012 - 2015 The role of inflammatory responses and tumor immunity in tumor development
- 2010 - 2015 Gastrointestinal tumorigenesis by cooperation of oncogenic activation and inflammatory responses
- 2010 - 2012 Regulation of Wnt activity by SOX17 in gastrointestinal tumorigenesis
- 2009 - 2011 Gastric tumorigenesis through cooperation of COX-2/PGE2 pathway and inflammatory responses
- 2007 - 2009 Development of the end of life care model in the rooted special elderly nursing homes
- 2005 - 2009 Epitehial-stromal interactions and molecularly targeted therapy
- 2007 - 2008 Activation of Wnt signaling through PGE2 induction in gastric tumorigenesis
- 2007 - 2008 CXCL14 and tissue macrophages in gastrointestinal tumorigenesis
- 2007 - 新規胃がんモデルマウスの作製と解析
- 2007 - Construction of novel gastric cancer mouse model
- 2005 - 2006 Cooperation of Wnt signaling and COX-2 pathway in gastric carcinogenesis
- 2005 - 2006 炎症反応に起因した胃粘膜上皮細胞の腫瘍性増殖機序の研究
- 2003 - 2004 COX-2 and mPGES on proliferation-differentiation cycle of epithelial cells
- 消化管腫瘍発生における炎症刺激の作用
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Papers (79)：
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Yukinori Ikeda, Hiroko Oshima, Sau Yee Kok, Masanobu Oshima, Yukiko T. Matsunaga. Spatiotemporal observation reveals metastatic tumor-driven vascular remodeling as a potential route to polyclonal colonization. 2024
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Kaori Yoshimura, Yukinobu Ito, Mina Suzuki, Masafumi Horie, Takumi Nishiuchi, Yukako Shintani-Domoto, Kazuyoshi Shigehara, Hiroko Oshima, Masanobu Oshima, Akiteru Goto, et al. Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry. Pathology international. 2024
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Dong Wang, Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Masanobu Oshima. Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling-Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors. Cancer research. 2024. 84. 1. 56-68
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Sau Yee Kok, Mizuho Nakayama, Atsuya Morita, Hiroko Oshima, Masanobu Oshima. Genetic and nongenetic mechanisms for colorectal cancer evolution. Cancer science. 2023. 114. 9. 3478-3486
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Atsuya Morita, Mizuho Nakayama, Hiroko Oshima, Masanobu Oshima. In Vitro and In Vivo Models for Metastatic Intestinal Tumors Using Genotype-Defined Organoids. Methods in molecular biology (Clifton, N.J.). 2023. 2691. 19-30
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MISC (39)：
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Hiroki Sato, Ryu Imamura, Katsuya Sakai, Hiroko Oshima, Masanobu Oshima, Kazuhiro Murakami, Yumi Terakado, Yukinari Kato, Seiji Yano, Kunio Matsumoto. Roles of Mature HGF in Gastric Tissue Regeneration and Tumorigenesis. CANCER SCIENCE. 2021. 112. 422-422
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寺門侑美, 村上和弘, 大島浩子, 大島正伸, BARKER Nick, BARKER Nick. 進行性胃癌発生および進行における腫瘍内Lgr5陽性幹細胞プールの役割. 日本癌学会学術総会抄録集(Web). 2021. 80th
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大木 理恵子, 大塚 旬子, 大島 浩子, 安部 良, 大島 正伸. がん抑制遺伝子p53機能喪失とがん微小環境は協調的に胃がん悪性化を促進する(Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers). 日本癌学会総会記事. 2018. 77回. 1074-1074
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寺門 侑美, 村上 和弘, 大島 正伸, 大島 浩子, Nick Barker. 胃がん幹細胞の検討とその制御機構(Analysis of gastric cancer stem cells and regulatory mechanism). 日本癌学会総会記事. 2018. 77回. 2098-2098
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出口敦子, 丸義朗, 大島正伸, 大島浩子. Toll様受容体内因性リガンドによるがん微小環境形成に伴う胃がん増悪化. 金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的研究拠点. 2017. 2016. 147
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Lectures and oral presentations (3)：
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消化器がんのポリクローナル転移機構
(第40回 腫瘍病理セミナー・北信がんプロFD講演会 金沢女性研究者フォーラム 2022)
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The fibrotic microenvironment that promote polyclonal metastasis of intestinal tumors.
(2021)
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FOXO3, A latent tumor suppressor of gastric cancer.
(The 10th FUSCC-CRIKU Joint Symposium on Tumor Biology 2021 2021)
Education (3)：
- 1999 - 熊本大学 薬学博士(論文博士)
- 1989 - 1992 Kumamoto University School of Pharmacy
- - 1992 Kumamoto University Faculty of Pharmaceutical Science
Professional career (1)：
Work history (10)：
- 2016/04 - 現在 Kanazawa University Cancer Research Institute
- 2005 - 2016 金沢大学がん研究所(2012年よりがん進展制御研究所に名称変更) 助教
- 2005 - 2005 京都大学医学研究科 研究員(学術研究振興)
- 2003 - 2005 京都大学医学研究科先端領域融合医学研究機構 助手(特任)
- 2002 - 2003 Kyoto University Faculty of Medicine
- 2001 - 2002 医薬品副作用被害救済・研究振興調査機構 派遣研究員
- 2000 - 2001 Kyoto University Faculty of Medicine
- 1999 - 2000 万有製薬株式会社つくば研究所
- 1997 - 1999 米国メルク研究所
- 1992 - 1997 万有製薬つくば研究所
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Association Membership(s) (1)：
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