Art

J-GLOBAL ID：200902076458944707   Reference number：88A0508793

Pharmacokinetic and pharmacological properties of doxazosin mesilate in Japanese healthy adult volunteers.

新しいα遮断薬doxazosin mesilateの日本人健常者における薬物動態と薬理作用

Author (5)： EBIHARA AKIO (大分医大) ,  TSURU MASANOBU (大分医大) ,  OHASHI KYOICHI (大分医大) ,  FUJIMURA AKIO (大分医大) ,  KONDO KAZUOKI (自治医大)
Material： 臨床薬理  (Japanese Journal of Clinical Pharmacology and Therapeutics)
Volume： 19  Issue： 2  Page： 445-452  Publication year： Jun. 1988 
JST Material Number： F0384B  ISSN： 0388-1601  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： adrenergic blocking drug ,...
Semi thesaurus term： doxazosin ,...

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JST classification (2)： Clinical application of sympatholytics  (GW05025G) ,  Clinical application of vasoactive drugs and hypotensive drugs  (GW07050U)

Reference (18)：

• 1) 海老原昭夫: 新しい降圧薬のまとめ.治療, 63: 1189-1193 (1981).
• 2) Cambridge, D. and Davey, M. J.: Comparison of the α-adrenoceptors located on sympathetic and parasympathetic nerve terminals. Br. J. Pharmacol., 69: 345-346 (1979).
• 3) Timmermans, P. B. M. W. M., Kwa, H. Y., Karamat Ali, F. et al.: Prazosin and its analogues UK-18, 596 and UK-33, 274: A comparative study on cardiovascular effects and α-adrenoceptor blocking activities. Arch. Int. Pharmacodyn., 245: 218-235 (1980).
• 4) Wilson, V. G., Wilson, K. A. and Downing, O. A.: An in vitro comparison of prazosin and its congeners UK-18596 and UK-33274 on vascular muscle. J. Pharm. Pharmacol., 33 (Suppl.): 40 (1981).
• 5) Vincent, J., Hamilton, C. A., Sumner, D. J. et al.: A comparison of the hypotensive activity and in vitro and in vivo α1-adrenoceptor antagonist properties of prazosin, trimazosin and doxazosin in the rabbit. Br. J. Pharmacol., 79: 388 (1983).

Terms in the title (5)： α遮断薬 ,  日本人 ,  健常者 ,  薬物動態 ,  薬理作用