ProTherm: Thermodynamic Database for Protein and Mutants

The data in the ProTherm database include thermodynamic parameters such as Gibbs free energy change, enthalpy change, heat capacity change, transition temperature etc., for wild type and mutant proteins that are important for understanding the structure and stability of proteins. There is also information about the secondary structure and accessibility of wild type residues, experimental conditions (pH, temperature, buffer, ion and protein concentration), measurements and methods used for each data, and activity information (Km and Kcat).