ProNIT: Thermodynamic Database for Protein-Nucleic Acid Interactions

The ProNIT database provides data on experimentally determined thermodynamic interactions between proteins and nucleic acids. The properties of the interacting protein and nucleic acid, reference materials, and thermodynamic parameters like binding constants, changes in free energy, enthalpy and heat capacity are available. Thermodynamic knowledge of proteins is as fundamental as sequence and structural information, because proteins behave according to the law of thermodynamics. Biological function of proteins can thus be studied.