Art

J-GLOBAL ID：201702225291937029   Reference number：17A0140058

Development of Novel High-Sensitivity Analytical Methods for Lansoprazole and Its Metabolite, and Metoprolol and Its Metabolites, Glibenclamide, and Warfarin in Human Plasma using LC-MS/MS

ヒト血漿におけるランソプラゾールとその代謝産物,メトプロロールとその代謝産物,グリベンクラミド,およびワルファリンのLC-MS/MSを使用した新しい高感度分析法の開発

Author (12)： NAKAMURA Takeshi (Kanazawa Univ.) ,  NAKAMURA Takeshi (Shin Nippon Biomedical Lab.) ,  IWASAKI Kazuhide (Shin Nippon Biomedical Lab.) ,  KAMBAYASHI Yasuhiro (Kanazawa Univ.) ,  TSUJIGUCHI Hiromasa (Kanazawa Univ.) ,  HORI Daisuke (Kanazawa Univ.) ,  HIBINO Yuri (Kanazawa Univ.) ,  SHIBATA Aki (Kobe Shoin Women’s Univ.) ,  HAYASHI Koichi (Mukogawa Women’s Univ.) ,  SAGARA Takiko (Kansai Univ. Welfare Sci.) ,  KONOSHITA Tadashi (Univ. Fukui Fac. Medical Sci.) ,  NAKAMURA Hiroyuki (Kanazawa Univ.)
Material： 体力・栄養・免疫学雑誌  (Journal of Physical Fitness, Nutrition and Immunology)
Volume： 26  Issue： 1  Page： 3-11  Publication year： Sep. 01, 2016 
JST Material Number： L3865A  ISSN： 1341-0865  CODEN： JPFIFM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *LC/MS/MS

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JST classification (1)： Clinical biopharmacy  (GY01022L)

Substance index (6)： Lansoprazole ,  Metoprolol ,  Glibenclamide ,  Warfarin ,  5-Hydroxylansoprazole ,  α-Hydroxymetoprolol

Reference (15)：

• FDA (2012) Guidance for Industry: Drug Interaction Studies -Study Design, Data Analysis, and Implications for Dosing and Labeling. Recommendations Draft Guidance, http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm292362.pdf.
• EMA (2012) Guideline on the Investigation of Drug Interaction. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf.
• Song, M, Gao, X, Hang, TJ, Wen, AD: Pharmacokinetic properties of lansoprazole (30-mg-enteric-coated capsules) ant its metabolites: A single-dose, open-label study in healthy Chinese male subjects. Current Therapeutic Research, Clinical and Experimental 2009;70:228-39.
• PMDA (2013) Drug Interview Form, www.info.pmda.go.jp/go/interview/1/400256_2329023F1020_1_006_1F.
• PMDA (2014) Drug Interview Form, http://www.info.pmda.go.jp/go/interview/1/780069_3961003F1087_1_006_1F.

Terms in the title (10)： ヒト ,  血漿 ,  ランソプラゾール ,  代謝産物 ,  メトプロロール ,  グリベンクラミド ,  ワルファリン ,  LC-MS ,  感度分析 ,  開発