Rchr
J-GLOBAL ID：201001049040159728   Update date: Feb. 29, 2024

Minamishima Yoji Andrew

Minamishima Yoji Andrew
Affiliation and department：
Professor, Department of Biochemistry, Gunma University Graduate School of Medicine

About Professor, Department of Biochemistry, Gunma University Graduate School of Medicine


Homepage URL  (2)： http://biochemistry.med.gunma-u.ac.jp ,  http://biochemistry.med.gunma-u.ac.jp/en/
Research field  (4)： Pathobiochemistry ,  Medical biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (6)： Cellular senescence ,  Cell cycle ,  Hydrogen sulfide ,  Cancer biology ,  Metabolism ,  Hypoxia
Research theme for competitive and other funds  (15)：
  • 2021 - 2024 Regulation of chronic inflammation of blood vessels by a bioactive lipid mediator
  • 2021 - 2024 不可逆的に増殖停止したはずの老化細胞が再増殖するための分子メカニズムの解明
  • 2020 - 2023 敗血症性心筋障害治療における低酸素応答依存的トリプトファン代謝の分子機構の解明
  • 2016 - 2021 Elucidation of the regulatory mechanism of metabolism in response to hypoxia by hydroxylation omics analysis
  • 2014 - 2019 Investigation of hypoxia adaptation and metabolic regulation in the cancer- and senescence-resistant rodent, the naked mole rat.
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Papers (37)：
  • Xian Zhao, Keisuke Kiyozuka, Akimitsu Konishi, Reika Kawabata-Iwakawa, Yoji Andrew Minamishima, Hideru Obinata. Actin-binding protein Filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1. The Journal of biological chemistry. 2023. 104851-104851
  • Hidetada Hirakawa, Ayako Takita, Yumika Sato, Suguru Hiramoto, Yusuke Hashimoto, Noriyasu Ohshima, Yoji A. Minamishima, Masami Murakami, Haruyoshi Tomita. Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli. Microbiology Spectrum. 2023
  • Keisuke Kiyozuka, Xian Zhao, Akimitsu Konishi, Yoji Andrew Minamishima, Hideru Obinata. Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3. Journal of biochemistry. 2023
  • Hajime Takamori, Toshinari Yamasaki, Rui Kitadai, Yoji Andrew Minamishima, Eijiro Nakamura. Development of drugs targeting hypoxia-inducible factor against tumor cells with VHL mutation: Story of 127 years. Cancer science. 2023. 114. 4. 1208-1217
  • Bilguun Erkhem-Ochir, Barbara Chivarina, Takehiko Yokobori, Evgenia Turtoi, Hideru Obinata, Gombodorj Navchaa, Yoji Andrew Minamishima, Toshiyuki Matsuzaki, Hiroshi Saeki, Masahiko Nishiyama, et al. LTBP2 is a novel marker in hepatocellular carcinoma. Cancer science. 2021. 112. 755-755
ｍore...
MISC (80)：
  • 南嶋 洋司. 肺癌病理における腫瘍微小環境 肺癌微小環境での低酸素応答と腫瘍免疫. 肺癌. 2022. 62. 6. 510-510
  • 南嶋 洋司. 細胞内シグナルの開始・継続・終焉に働く多様なタンパク質分解機構 酸素濃度依存的プロリン水酸化とユビキチン-プロテアソーム系蛋白分解による低酸素応答の制御. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3S15m-06
  • 南嶋洋司. Molecular mechanism of HIF-PH inhibition and hypoxic response activation. 腎と透析. 2022. 93. 2. 171-177
  • 南嶋洋司. General remarks Past and future of Hypoxic response research. 月刊細胞. 2022. 54. 7. 354-355
  • Tserendavga Binderiya, 大嶋 紀安, 藤田 千明, 湯澤 厚二, 大嶋 麻理, 矢中 規之, 南嶋 洋司, 和泉 孝志. マウス由来GDE7は環状ホスファチジン酸を産生する酵素活性を有する. 脂質生化学研究. 2022. 64. 247-249
ｍore...
Patents (3)：
Books (4)：
  • Lippincott Illustrated Reviews: Biochemistry, Edition 8
    Wolters Kluwer 2023 ISBN:9784621308523
  • 透析療法ネクストXXVII〜腎性貧血治療薬HIF-PH阻害薬への期待と課題:保存期から透析期まで〜
    医学図書出版 2021 ISBN:9784865174397
  • 全人力・科学力・透析力・for the people 透析医学
    医薬ジャーナル社 2014 ISBN:9784753226795
  • 見つける、量る、可視化する!質量分析実験ガイド
    羊土社 2013 ISBN:9784758101868
Lectures and oral presentations  (148)：
  • シンポジウム13:肺癌病理における腫瘍微小環境「肺癌微小環境での低酸素応答と腫瘍免疫」
    (第63回日本肺癌学会学術集会 2022)
  • シンポジウム:細胞内シグナルの開始・継続・終焉に働く多様なタンパク質分解機構「酸素濃度依存的プロリン水酸化とユビキチン-プロテアソーム系蛋白分解による低酸素応答の制御」
    (第95回日本生化学会 2022)
  • シンポジウム:HIFと鉄代謝「HIFを介した低酸素応答の分子メカニズム」
    (第46回日本鉄バイオサイエンス学会学術集会 2022)
  • Modulation of cellular senescence by branched-chain amino acid metabolism
    (日本分子生物学会年会プログラム・要旨集(Web) 2021)
  • 低酸素応答の臨床応用〜HIF-PH阻害薬と腎性貧血などの疾患の治療〜
    (第53回九州人工透析研究会総会 2021)
ｍore...
Education (2)：
  • 1998 - 2002 Kyushu University Graduate School of Medical Science
  • 1987 - 1993 Kyushu University School of Medicine Department of Medicine
Professional career (2)：
  • M.D. (Kyushu University)
  • Ph.D. (Kyushu University)
Work history (11)：
  • 2018/12 - 現在 Professor, Department of Biochemistry, Gunma University Graduate School of Medicine
  • 2016/04 - 2018/11 Project Associate Professor, Division of Cell Biology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
  • 2010/09 - 2016/03 Assistant Professor, Department of Biochemistry, Keio University School of Medicine
  • 2010/09 - 2016/03 Group Leader, ERATO, Japan Science and Technology Agency (JST)
  • 2004/09 - 2010/08 Research Fellow, Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School
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Committee career (4)：
  • 2022/09 - 現在 The Japanese Biochemical Society Trustee
  • 2021/04 - 現在 J-MICA (Japanese Medical University International Collaborative Assembly) Delegate member
  • 2019/04 - 現在 群馬大学 人を対象とする医学系研究倫理審査委員会 研究倫理審査委員
  • 2013/10 - 現在 Cancer and Metabolism Meeting Executive committee
Awards (4)：
  • 2017/03 - The Japanese Pharmacological Society Young Investigator Outstanding Oral Presentation Award, The 90t Annual Meeting of the Japanese Pharmacological Society Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis
  • 2011/11 - 公益財団法人 武田科学振興財団 平成23年度医学系研究助成賞 メタボローム解析を駆使した、低酸素応答によるインスリン感受性の制御機構の解明
  • 2011/05 - 公益財団法人 日本腎臓財団 平成23年度若手研究者助成賞 成人肝細胞のエリスロポイエチン産生能力再活性化と、その腎性貧血治療への応用
  • 2009/08 - Dana-Farber Cancer Institute 5th Annual Postdoc and Grad Student Retreat Best Poster Presentation Award "Detrimental effect of chronic HIF activation in vivo"
Association Membership(s) (9)：
THE JAPANESE CANCER ASSOCIATION ,  The Japanese Biochemical Society ,  The Molecular Biology Society of Japan ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  American Association for Cancer Research ,  JAPAN SURGICAL ASSOCIATION ,  THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY ,  JAPAN SURGICAL SOCIETY
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