mori nozomu

Research field (3)： Medical biochemistry , Neuroscience - general , Molecular biology

Research keywords (33)： longevity , リン酸化チロシンアダプター蛋白質 , 神経 , クロマチン , アクチン , 神経遣伝子 , 樹状突起 , 老化 , 転写因子 , 転写制御 , Grit , 神経可塑性 , サイレンサー , N-Shc , 神経遺伝子 , アクチン骨格 , HDAC , 細胞骨格制御 , シナプス , リン酸化チロシンアダプター , 神経分化 , ダウン症 , プロモーター , 遺伝子 , Homer , 基本転写因子 , 樹状突起スパイン , スパイン , Shc , 海馬 , 可塑性 , 包括脳ネットワーク , 統合脳・分子脳科学

Research theme for competitive and other funds (13)：

2017 - 2021 Molecular analysis of neural-specific phosphotyrsine signal adaptor, ShcB and ShcC
2015 - 2018 Regulatory roles of NRSF/REST variants in the aging brain
2014 - 2018 Regulation of neuronal ageing through the mTOR signaling by acetylation
2012 - 2015 Establishment of an in vitro aging system of non-dividing cells
2010 - 2013 Positive and negative regulations of cytoskeletal dynamism and neuronal lifespan

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Papers (90)：

Sho Kakizawa, Yasushi Kishimoto, Shinichiro Yamamoto, Kazuko Onga, Kunihiko Yasuda, Yoshiaki Miyamoto, Masahiko Watanabe, Ryuichi Sakai, Nozomu Mori. Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells. Scientific reports. 2020. 10. 1. 14475-14475
Nozomu Mori. [Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2020. 140. 3. 395-404
Miwako Kawamura, Shigeto Sato, Gen Matsumoto, Takahiro Fukuda, Kahori Shiba-Fukushima, Sachiko Noda, Masashi Takanashi, Nozomu Mori, Nobutaka Hattori. Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients. Neuroscience letters. 2019. 699. 59-63
Gen Matsumoto, Tomonao Inobe, Takanori Amano, Kiyohito Murai, Nobuyuki Nukina, Nozomu Mori. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Scientific reports. 2018. 8. 1. 9585-9585
Gen Matsumoto, Kazuki Matsumoto, Taeko Kimura, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahara, Nozomu Mori. Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy. International journal of molecular sciences. 2018. 19. 5

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MISC (19)：

Sho Kakizawa, Yasushi Kishimoto, Shinichiro Yamamoto, Kazuko Onga, Kunihiko Yasuda, Ryuichi Sakai, Hiroshi Takeshima, Nozomu Mori. Regulation of Intracellular Calcium Store by a Phosphotyrosine Adaptor ShcB in Cerebellar Purkinje Cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 100P-100P
柿澤昌, 柿澤昌, 岸本泰司, 山本伸一郎, 大神和子, 安田邦彦, 堺隆一, 竹島浩, 森望. ホスホチロシンアダプターShcB欠損マウスにおける小脳機能とプルキンエ細胞内カルシウムシグナル系の阻害. 基礎老化研究. 2013. 37. 2
Sho Kakizawa, Toshiko Yamazawa, Takashi Murayama, Hideto Oyamada, Nagomi Kurebayashi, Masahiko Watanabe, Nozomu Mori, Katsuji Oguchi, Takashi Sakurai, Hiroshi Takeshima, et al. Nitric oxide-induced Ca2+release (NICR) mediated by ryanodine receptor 1 is essential for synaptic plasticity in the cerebellum. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 104P-104P
Sho Kakizawa, Masahiko Shibazaki, Nozomu Mori, Hiroshi Takeshima. Protein Oxidation Inhibits Nitric Oxide-Mediated Signaling Pathway Essential for Synaptic Plasticity. BIOPHYSICAL JOURNAL. 2011. 100. 3. 89-89
Sho Kakizawa, Toshiko Yamazawa, Takashi Murayama, Hideto Oyamada, Nagomi Kurebayashi, Masahiko Watanabe, Nozomu Mori, Katsuji Oguchi, Takashi Sakurai, Hiroshi Takeshima, et al. Nitric oxide-induced calcium release mediated by ryanodine receptors is a novel calcium-releasing mechanism essential for synaptic plasticity in the cerebellum. NEUROSCIENCE RESEARCH. 2011. 71. E86-E86

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Work history (11)：

2006 - 2019/03 Nagasaki University Graduate School of Biomedical Sciences
2007 - 長崎大学医歯薬学総合研究科・大学院教授
2004 - 長崎大学医歯薬学総合研究科・大学院教授
2004 - 国立長寿医療センター
2002 - 2003 国立長寿医療研究センター分子遺伝学研究部部長(研究職)

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