Rchr
J-GLOBAL ID：201101050076332642
Update date: Apr. 21, 2024
Mizuno Hideaki
ミズノ ヒデアキ | Mizuno Hideaki
Affiliation and department：
Homepage URL (1)：
http://dna00.bio.kyutech.ac.jp/mizuno/research.html
Research field (4)：
Biological, health, and medical informatics
, Tumor biology
, Molecular biology
, Genomics
Research keywords (8)：
Artificial life
, Simulation
, Systems biology
, Biostatistics
, Genome biology
, Digital pathology
, Data science
, Bioinformatics
Papers (22)：
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Hironori Fukuda, Kosuke Arai, Hideaki Mizuno, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, et al. Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments. Cancer Science. 2024
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Kana Ohashi, Yukari Nishito, Hironori Fukuda, Ryoichi Sadahiro, Yukihiro Yoshida, Shun-Ichi Watanabe, Noriko Motoi, Yukiko Sonobe, Hideaki Mizuno, Hiroyuki Tsunoda, et al. Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer. Scientific reports. 2024. 14. 1. 429-429
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Kazunori Aoki, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, Eri Hashimoto, Mina Takahashi, et al. Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations. Cancer research communications. 2023. 3. 6. 1026-1040
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Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, et al. Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion. mAbs. 2023. 15. 1. 2253570-2253570
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Hideaki Mizuno. Digital workflows for pathological assessment of rat estrous cycle stage using images of uterine horn and vaginal tissue. Journal of Pathology Informatics. 2022. 13. 100120-100120
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MISC (30)：
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Kosuke Arai, Kazunori Aoki, Hironori Fukuda, Noriko Motoi, Yasuhito Arai, Akiyosi Hirayama, Hideaki Mizuno, Yukari Nisito, Hiroyuki Tsunoda. Molecular Subtypes of Lung Adenocarcinoma Present Distinct Immune Tumor Microenvironments. 2023
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Hideaki Mizuno. Identification of two immune subtypes in pancreatic ductal adenocarcinoma with characteristic signaling pathways. Cancer Science. 2023
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Hideaki Mizuno. Precise profiling of TILs defines three immune subtypes of NSCLC with distinct signaling pathways. Cancer Science. 2023
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Kazunori Aoki, Yukari Nishito, Hideaki Mizuno, Hiroyuki Tsunoda, Atsushi Ochiai. Exploration of novel targets for the development of lung cancer immunotherapy based on the immune tumor microenvironment. 2022
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Kyoko Yamaguchi, Etsuko Fujii, Shuichi Mitsunaga, Noriaki Sawada, Masafumi Ikeda, Takashi Fujitomo, Hideaki Mizuno, Yoko Kayukawa, Mayu Makikawa, Kazunori Aoki, et al. Abstract 6145: Increased PD-L1 expression levels were observed on both tumor cells and macrophages by tocilizumab plus gemcitabine/nab-paclitaxel treatment in gemcitabine/nab-paclitaxel-refractory metastatic pancreatic cancer patients. Cancer Research. 2022. 82. 12_Supplement. 6145-6145
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Patents (2)：
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NOVEL METHOD FOR SPECIMEN PREPARATION, WHICH ENSURES PRESERVATION OF TISSUE MORPHOLOGY AND NUCLEIC ACID QUALITY.
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ANTIGEN-BINDING MOLECULE CONTAINING ANTIGEN-BINDING DOMAIN OF WHICH BINDING ACTIVITY TO ANTIGEN IS CHANGED DEPENDING ON MTA, AND LIBRARY FOR OBTAINING SAID ANTIGEN-BINDING DOMAIN
Books (1)：
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革新的AI創薬
エヌ・ティー・エス 2022 ISBN:9784860437886
Lectures and oral presentations (5)：
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多層的オミックスデータベース構築による肺がん免疫システムの解明
(Dialogue Webinar 2021)
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多層的オミックスデータベース構築による腫瘍免疫システムの解明と医薬品開発への応用
(ゲノム創薬・創発フォーラム 第5回シンポジウム 2021)
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製薬企業研究員のキャリアパス
(第2回生命医薬情報学連合大会 2013)
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ハプロタイプエントロピー法を用いたヒトゲノム中の人種特異的連鎖不平衡領域の高解像度検出
(IPA UGM 2012 2012)
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PrognoScan: a new database for meta-analysis of the prognostic value of genes
(The 2010 Annual Conference of the Japanese Society for Bioinformatics 2010)
Works (3)：
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ENIGMA
水野英明 2010 -
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PrognoScan: a new database for meta-analysis of the prognostic value of genes
Hideaki Mizuno 2009 -
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ORI-GENE: A Tool for Gene Classi cation Based on Evolutional Tree
Hideaki Mizuno 2001 -
Professional career (1)：
Work history (4)：
- 2002 - 現在 Chugai Pharmaceutical Discovery science & Technology Department
- 2009 - 2010 The Simons Center for Systems Biology, Institute for Advanced Study
- 2000 - 2002 Nippon Roche Department of Genome Science
- 1999 - 2000 Tsukuba Life Science Center, RIKEN
Committee career (1)：
- 2012 - 2015 Japanese Society for Bioinformatics Board Member
Awards (1)：
- 2021/12 - 日本DNA多型学会 優秀研究賞 ヘビからカエルへの遺伝子水平伝播:脊椎動物間水平伝播の地理的特異性と発生様式に関する新知見
Association Membership(s) (3)：
THE BIOPHYSICAL SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR BIOINFORMATICS
, THE JAPANESE CANCER ASSOCIATION
