Doi Hiroshi

ドイヒロシ | Doi Hiroshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/10326035

Research field (1)： Neurology

Research keywords (3)： neurogenetics , neurodegenerative diseases , 包括脳ネットワーク

Research theme for competitive and other funds (23)：

2024 - 2027 新規動物モデル、iPS細胞モデルを用いたCANVASの病態解明
2022 - 2025 Analysis of pathological dynamics of membrane-less organelles in SALS
2022 - 2025 SCA42疾患修飾治療に向けた病態基盤の解明
2021 - 2024 扁桃体腫大を伴う側頭葉てんかんの病態背景の解明と新規治療法の開発
2021 - 2024 新規イントロンリピート病CANVASの病態解析モデルの構築

2021 - 2024 単球系細胞から捉えた全身炎症による神経変性疾患の病態進展の機序解明

2021 - 2024 Development of disease-modifying therapy for spinocerebellar ataxia type 42 and elucidation of pathophysiological basis using optogenetic methods

2019 - 2022 DEAD box RNA helicases are involved in sporadic ALS pathology

2018 - 2021 Analysis of UBQLN2 based on loss of function model

2018 - 2021 Development of novel therapeutic strategy against neurodegenerative diseases by modulation of monocyte-lineage cell

2018 - 2021 Development of ALS therapy targeting LOTUS, a functional molecule for neuronal regeneration

2018 - 2021 Elucidation of pathophysiology and development of treatment for spinocerebellar ataxia using a novel mouse model

2017 - 2019 Elucidation of abnormal accumulation of DDX17 in motor neuron of ALS

2017 - 2019 Clarification of the pathological mechanism of VGCC associated diseases

2016 - 2018 Neural substrates of masked-face in Parkinson disease: A quantitative analysis of facial expression.

2015 - 2018 Analysis of genetic back ground and pathomechanism of spinocerebellar degeneration

2015 - 2017 Analysis of polyglutamine aggregation protein in ALS/FTLD

2014 - 2016 Analysis of RNA binding proteins in polyglutamine disease

2013 - 2016 Integrated research of polyglutamine disease and ALS/FTLD by analysis of UBQLN2

2013 - 2016 Establishment of diagnosis method and analysis of genetic background of adult leukoencephalopathy patients with desktop next-generation sequencer

2010 - 2015 Exploration of disease-related genes based on personal genome analysis and elucidation of pathogenesis in ALS

2012 - 2014 Exome analysis of spinocerebellar ataxias

2010 - 2011 Isolation of causative genes for recessive spinocerebellar ataxia

Show all

Papers (146)：

Takuya Ikeda, Keita Takahashi, Minatsu Higashi, Hiroyasu Komiya, Tetsuya Asano, Akihiro Ogasawara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Kenichi Tanaka, et al. Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice. Cell death discovery. 2023. 9. 1. 454-454
Taishi Wada, Hiroshi Doi, Masaki Okubo, Mikiko Tada, Naohisa Ueda, Hidefumi Suzuki, Wakana Tominaga, Haruki Koike, Hiroyasu Komiya, Shun Kubota, et al. RNA foci in two bi-allelic RFC1 expansion carriers. Annals of neurology. 2023
小林怜右, 古宮裕泰, 小林絵礼奈, 橋口俊太, 高橋慶太, 東山雄一, 土井宏, 田中章景. 両側声帯麻痺を呈し気管切開術を要したβプロペラ蛋白関連神経変性症(BPAN)の57歳女性例. 臨床神経学. 2023. 63. 11. 775-775
細田航平, 古宮裕泰, 橋口俊太, 田中健一, 宮地洋輔, 土井宏, 竹内英之, 田中章景. 家系内で異なる臨床像を呈しVCP遺伝子バリアントを認めた家族性筋萎縮性側索硬化症の兄弟例. 臨床神経学. 2023. 63. 9. 605-605
Hiromi Fukuda, Takeshi Mizuguchi, Hiroshi Doi, Shinichi Kameyama, Misako Kunii, Hideto Joki, Tatsuya Takahashi, Hiroyasu Komiya, Mei Sasaki, Yosuke Miyaji, et al. Long-read sequencing revealing intragenic deletions in exome-negative spastic paraplegias. Journal of human genetics. 2023. 68. 10. 689-697

ｍore...

MISC (186)：

Hiroshi Doi, Fumiaki Tanaka. [Chronic Cough in CANVAS]. Brain and nerve = Shinkei kenkyu no shinpo. 2022. 74. 11. 1267-1271
Yosuke Miyaji, Hiroshi Doi, Fumiaki Tanaka. [Motor Neuron Involvement in RFC1 CANVAS/Spectrum Disorders]. Brain and nerve = Shinkei kenkyu no shinpo. 2022. 74. 11. 1287-1291
森下良志, 原田康平, 古宮裕泰, 橋口俊太, 田中健一, 多田美紀子, 土井宏, 田中章景. 舞踏運動を主徴とし、抗リン脂質抗体と抗amphiphysin抗体が陽性であった69歳男性例. 臨床神経学. 2022. 62. 8. 676-676
原田康平, 田中健一, 城野誉士, 宮地洋輔, 多田美紀子, 土井宏, 竹内英之, 田中章景. 心筋症で発症した抗横紋筋抗体陽性重症筋無力症の67歳男性例. 臨床神経学. 2022. 62. 4. 329-329
田中玲子, 澤住知枝, 木村活生, 多田美紀子, 土井宏, 千葉佐和子, 大谷方子, 上田直久, 田中章景, 稲山嘉明. 神経フェリチン症の肺病変肺内フェリチン封入体と高度肺気腫を呈した1剖検報告. 診断病理. 2022. 39. 2. 120-125

ｍore...

Books (1)：

前頭側頭葉変性症の療養の手引き
平成28年度厚生労働科学研究費補助金難治性疾患等政策研究事業(難治性疾患政策研究事業)「神経変性疾患における基盤的調査研究」班 2017

Education (2)：

2002 - 2006 Yokohama City University Graduate School of Medicine Department of Neurology
1992 - 1998 Niigata University School of Medicine

Work history (8)：

2016/04 - 現在 School of Medicine, Yokohama City University Department of Neurology and Stroke Medicine Associate Professor
2012/04 - 2016/03 School of Medicine, Yokohama City University Department of Neurology and Stroke Medicine Lecturer
2010/01 - 2012/03 School of Medicine, Yokohama City University Department of Human Genetics Assistant Professor
2008/04 - 2009/12 School of Medicine, Yokohama City University Department of Clinical Neurology and Stroke Medicine Assistant Professor
2006/04 - 2008/03 National Hospital Organization Yokohama Medical Center Department of Neurology Head of Neurologist

Show all

Committee career (2)：

2020/08 - 現在日本脳卒中学会代議員
2017/09 - 現在日本神経学会代議員

Awards (2)：

2018/11 - 武田科学振興財団医学系研究助成
2011 - YokohamaCity University Medical Association Encouragement Prize for Medical Research

Association Membership(s) (7)：

Japanese Society of Neurological Therapeutics , 日本神経感染症学会 , THE JANPANESE SOCIETY OF INTERNAL MEDICINE , The Japan Society of Human Genetics , JAPAN SOCIETY FOR DEMENTIA RESEARCH , The Japan Stroke Society , SOCIETAS NEUROLOGICA JAPONICA

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page