Nagai Makiko

ナガイマキコ | Nagai Makiko

Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/80420488

Research field (1)： Neurology

Research keywords (31)：包括脳ネットワーク , 筋萎縮性側索硬化症 , SOD1 , トランスジェニックマウス , 筋萎縮性側索硬化症(ALS) , ALS , アストロサイト , 脊髄 , レチノイド , 運動ニューロン , Bax , 胚性幹細胞 , スーパーオキシドディスムターゼ1 , 初代培養 , 分化誘導 , オートファジー , 神経変性 , RNA , 神経栄養因子 , 髄腔内投与 , IGF-1 , 神経分子病態学 , 再生治療 , 神経幹細胞 , EGF , FGF2 , 分化 , 再生療法 , 蛋白療法 , 抗アポトーシス治療法 , 抗アポトーシス治療

Research theme for competitive and other funds (7)：

2019 - 2023 AAVを用いたTDP-43異常蛋白伝播の機序の解明
2012 - 2016 The production of newly ALS model mice
2009 - 2011 Analysis for factors toxic to motor neurons released from astrocytes expressing ALS-linked mutated SOD1.
2007 - 2008 Analysis of the mutated SOD1 astrocyte-releasing factors toxic to motor neurons
2006 - 2008 Molecular characterization and gene/regeneration therapy for amyotrophic lateral sclerosis

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Papers (78)：

Nobuyuki Eura, Satoru Noguchi, Masashi Ogasawara, Theerawat Kumutpongpanich, Shinichiro Hayashi, Ichizo Nishino, Takahiko Mukaino, Mori Yoshimura Madoka, Makiko Nagai, Masayuki Ochi, et al. Characteristics of the muscle involvement along the disease progression in a large cohort of oculopharyngodistal myopathy compared to oculopharyngeal muscular dystrophy. Journal of Neurology. 2023. 270. 12. 5988-5998
Hitoshi Aizawa, Haruhisa Kato, Koji Oba, Takuya Kawahara, Yoshihiko Okubo, Tomoko Saito, Makiko Naito, Makoto Urushitani, Akira Tamaoka, Kiyotaka Nakamagoe, et al. Randomized phase 2 study of perampanel for sporadic amyotrophic lateral sclerosis. Journal of neurology. 2021. 269. 2. 885-896
Akito Hattori, Etsuro Ohta, Makiko Nagai, Kazuya Iwabuchi, Hideyuki Okano. A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination. Methods (San Diego, Calif.). 2021
Etsuro Ohta, Takefumi Sone, Hideki Ukai, Tomoko Hisamatsu, Tokiko Kitagawa, Mitsuru Ishikawa, Makiko Nagai, Hiroki R. Ueda, Fumiya Obata, Hideyuki Okano. Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK2. Stem Cell Research. 2020. 49. 102073-102073
Xiao Zhang, Satoshi Yamashita, Kentaro Hara, Tsukasa Doki, Nozomu Tawara, Tokunori Ikeda, Yohei Misumi, Ziwei Zhang, Yoshimasa Matsuo, Makiko Nagai, et al. A mutant MATR3 mouse model to explain multisystem proteinopathy. The Journal of pathology. 2019. 249. 2. 182-192

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MISC (71)：

清水崇宏, 永井真貴子, 金子淳太郎, 金澤直美, 富永奈保美, 川浪文, 阿久津二夫, 飯塚高浩, 西野一三, 西山和利. 抗HMGCR抗体陽性壊死性ミオパチー4例の誘因と臨床像の検討. 臨床神経学. 2018. 58. Suppl. S270-S270
清水崇宏, 永井真貴子, 金子淳太郎, 金澤直美, 富永奈保美, 川浪文, 阿久津二夫, 飯塚高浩, 西野一三, 西山和利. 抗HMGCR抗体陽性壊死性ミオパチー4例の誘因と臨床像の検討. 臨床神経学. 2018. 58. Suppl. S270-S270
大日方友理, 岩下由佳, 永井真貴子, 服部精人, 江島耕二, 小幡文弥, 小幡文弥, 小幡文弥, 川村俊彦, 川村俊彦, et al. 遺伝性パーキンソン病患者iPS細胞由来神経幹細胞移植マウスの作製および病態解析. 日本再生医療学会総会(Web). 2018. 17th. ROMBUNNO.P-02-009 (WEB ONLY)
Ohta Etsuro, Nihira Tomoko, Uchino Akiko, Imaizumi Yoichi, Akamatsu Wado, Takahashi Kayoko, Nagai Makiko, Ohyama Manabu, Masafuchi Ryo, Ogino Mieko, et al. I2020T LRRK2 iPS細胞由来神経細胞はタウリン酸化の増加を呈する(I2020T LRRK2 iPSC-derived neurons exhibit increased Tau phosphorylation). 臨床神経学. 2015. 55. Suppl. S226-S226
川浪文, 永井真貴子, 仁平友子, 荻野美恵子, 西山和利. 孤発性ALS剖検脊髄におけるOptineurin陽性封入体の検討. 日本神経学会学術大会プログラム・抄録集. 2014. 55th. Suppl. 575-S98

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Work history (5)：

2010/04 - Kitasato University School of Medicine
2009 - 2010 Okayama University
2007 - 2009 Okayama University Medical School
2005 - 2007 Okayama University Medical School
2005 - Okayama University Medical School

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