Furutani Kazuharu

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://p.bunri-u.ac.jp/lab12/

Research field (5)： Clinical pharmacy , Physiology , Neuroscience - general , Biological, health, and medical informatics , Pharmacology

Research keywords (24)：シグナル伝達 , プルキンエ細胞 , 構造機能連関 , パッチクランプ , 薬理学 , 生理学 , 電位依存性カリウムチャネル , 心筋細胞 , グリア , 神経細胞 , 脂質 , 薬物 , 小脳 , カリウムチャネル , カルシウム , 包括脳ネットワーク , 分子イメージング , 電気生理学 , カルシウムイメージング , イオンチャネル , molecular imaging , electrophysiology , calcium signaling , ion channel

Research theme for competitive and other funds (11)：

2022 - 2025 Pathophysiological mechanism for mitochondrial Na/Ca exchanger and its therapeutic application
2021 - 2024 Molecular Mechanisms of Potassium Channel Facilitation by Blockers and its Impact on Arrhythmias
2015 - 2018 Regulation of the m2 muscarinic ACh receptor-mediated signaling by RGS proteins
2015 - 2017 TASKチャネルを標的とする低酸素応答機構に関する研究
2010 - 2016 Research and development of a software platform for integrative multi-level systems biology

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Papers (31)：

Kevin R DeMarco, Pei-Chi Yang, Vikrant Singh, Kazuharu Furutani, John R D Dawson, Mao-Tsuen Jeng, James Fettinger, Slava Bekker, Van A Ngo, Sergei Y Noskov, et al. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. Journal of molecular and cellular cardiology. 2021
Masami Kodama, Kazuharu Furutani, Reiko Kimura, Tomoko Ando, Kazuho Sakamoto, Shushi Nagamori, Takashi Ashihara, Yoshihisa Kurachi, Yuko Sekino, Tetsushi Furukawa, et al. Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes. Journal of pharmacological sciences. 2019. 140. 4. 325-330
Shinichi Uchida, Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, et al. Integrative and theoretical research on the architecture of a biological system and its disorder. The journal of physiological sciences : JPS. 2019. 69. 3. 433-451
Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen, Kenichiro Handa, Yuko Yamakawa, Jon T Sack, Yoshihisa Kurachi. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. The Journal of general physiology. 2019. 151. 2. 214-230
Yosuke Funato, Kazuharu Furutani, Yoshihisa Kurachi, Hiroaki Miki. CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption. The Journal of physiology. 2018. 596. 5. 743-746

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MISC (23)：

古谷和春, 津元国親, 陳以珊, 山川祐子, 倉智嘉久. 抗不整脈薬のhERGチャネルファシリテーション作用分子機序と不整脈治療における意義. 日本薬理学雑誌. 2013. 141. 3. 23P-23P
Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen, Yoshihisa Kurachi. Facilitation of hERG channel and its clinical relevance. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 166P-166P
Yuko Yamakawa, Kazuharu Furutani, Atsushi Inanobe, Yoshihisa Kurachi. in silico analysis of hERG channel facilitators. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 156P-156P
Daisuke Kamimura, Tomohito Ohtani, Yasushi Sakata, Toshiaki Mano, Yasuharu Takeda, Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Kazuharu Furutani, Yutaka Komiyama, et al. Inhibition of Ca2+Entry Mode of Na+/Ca2+Exchanger Improves Survival Rate of Rat Model for Heart Failure with Preserved Ejection Fraction. CIRCULATION. 2011. 124. 21
An integration of multi-level electrical activities in the heart: physiome/system biological approach towards in silico cardiology. 2011. 238. 3. 237-243

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Education (3)：

2003 - 2007 The University of Tokyo Graduate School of Medicine
2001 - 2003 Kyoto Pharmaceutical University
1997 - 2001 Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmacy

Professional career (1)：

Ph. D

Work history (5)：

2020/04 - 現在 Tokushima Bunri University Faculty of Pharmaceutical Sciences Associate Professor
2018/03 - 2020/03 University of California, Davis Department of Physiology and Membrane Biology Assistant Professor
2017/03 - 2018/02 University of California, Davis Department of Physiology and Membrane Biology Visiting Assistant Professor
2007/05 - 2018/02 大阪大学医学(系)研究科(研究院) 助教
2007/04 - 2007/04 Osaka University Graduate School of Medicine

Awards (3)：

2015/03 - 日本生理学会入澤宏・彩記念若手研究奨励賞
2013/08 - 大阪大学大阪大学総長奨励賞(研究部門)
2006/03 - 日本薬理学会第79回日本薬理学会年会年会優秀発表賞

Association Membership(s) (6)：

Biophysical Society , Society for Neuroscience , 日本生化学会 , 日本神経科学学会 , 日本生理学会 , 日本薬理学会

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