Research theme for competitive and other funds (15)：
2022 - 2026 Analysis of the redox dynamics of phosphorous by in-situ mearsurement
2023 - 2025 Genome and protein science, and environmental biology of high temperature adaptation of hot spring frog
2021 - 2025 Utilization of functions by cluster root formation for sustainable crop production
2016 - 2020 Development of a robust cultivation method of microalgae using phosphite and application to biocontainment
2016 - 2019 Analysis of the global cycling of phosphorus by microorganisms
2016 - 2017 Engineering phosphorus metabolic pathway for biological containment of genetically modified micoorganisms
2013 - 2015 Application of a phosphite dehydrogenase gene as a dominant selection marker for a large-scale cultivation of microorganisms
2012 - 2013 Development of a highly-functioned phosphite dehydrogenase by molecular engineering
2011 - 2012 Characterization of the reversion mechanisms of polyphosphate-accumulating mutants for the development of microofganisms for phosphorus recovery
2010 - 2012 Development of NADH regeneration system by thermostable phosphite dehydrogenase
2012 - 実用レベルでの利用を指向した可溶性の高い亜リン酸デヒドロゲナーゼの取得
2009 - 2010 The regulation of metabolic pathways by polyphosphate accumulation and its application to fermentation technology
2010 - Development of a method that confers acid resistance to desired bacteria
2009 - Development of a reduced fertilization system using polyphosphate-accumulating bacteria
2008 - Evaluation of the novel detection method of endotoxin by using a highly-sensitive luciferase
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Papers (59)：
Takeshi Ikeda, Yukihide Nakasugi, Miki Nakagawa, Shun-ichi Matsuura, Takuji Ikeda, Takenori Ishida, Hisakage Funabashi, Ryuichi Hirota, Akio Kuroda. Discovery of long-chain polyamines embedded in the biosilica on the Bacillus cereus spore coat. Journal of Bioscience and Bioengineering. 2024
Hiroki Murakami, Kosuke Sano, Kei Motomura, Akio Kuroda, Ryuichi Hirota. Assessment of horizontal gene transfer-mediated destabilization of Synechococcus elongatus PCC 7942 biocontainment system. Journal of bioscience and bioengineering. 2023. 135. 3. 190-195
Ikki Kobayashi, Sousuke Imamura, Ryuichi Hirota, Akio Kuroda, Kan Tanaka. Expression of bacterial phosphite dehydrogenase confers phosphite availability in a unicellular red alga Cyanidioschyzon merolae. Journal of General and Applied Microbiology. 2023. 69. 5. 287-291
Ryuichi Hirota, Zen-Ichiro Katsuura, Naoki Momokawa, Hiroki Murakami, Satoru Watanabe, Takenori Ishida, Takeshi Ikeda, Hisakage Funabashi, Akio Kuroda. Gatekeeper Residue Replacement in a Phosphite Transporter Enhances Mutational Robustness of the Biocontainment Strategy. ACS synthetic biology. 2022. 11. 10. 3397-3404
Engineering of Phosphorus Metabolic Pathway: A Safeguard Strategy for Greater Use of Genetically Modified Microorganisms
(International Congress on Pure & Applied Chemistry 2018 2018)
Engineering of Phosphorus Metabolic Pathway: A Safeguard Strategy for Greater Use of Genetically Modified Microorganisms
(The 9th International Symposium of Innovative Bioproduction Kobe 2018)
1999 - 2002 Hiroshima University Graduate School of Advanced Sciences of Matter
1997 - 1999 Hiroshima University Graduate School of Advanced Sciences of Matter
1993 - 1997 Hiroshima University Faculty of Engineering Cluster 3 (Chemistry, Biotechnology and Process Engineering)
Professional career (2)：
Dr. Engineering (Hiroshima University)
Master of Engineering (Hiroshima University)
Work history (3)：
2017/06 - 現在 Graduate School of Advanced Sciences of Matter Associate Professor
2007/03/01 - 2017/05/31 Graduate School of Advanced Sciences of Matter Assistant Professor
2013/09/28 - 2014/11/28 University of Illinois Urbana-Champaign Visiting Scholar
Association Membership(s) (4)：
Japan Society for Environmental Biotechnology
, The Japan Society for Bioscience, Biotechnology, and Agrochemistry
, The Society for Biotechnology
, American society for microbiology
