Research theme for competitive and other funds (15):
2023 - 2026 表皮水疱症の創傷治癒遅延因子の同定とその克服
2021 - 2024 加齢に着目した皮膚の免疫自己寛容破綻機序の解明
2020 - 2023 エピトープスプレディング現象に着目した水疱性類天疱瘡の病態解明
2018 - 2021 表皮水疱症の治療最適化戦略
2016 - 2019 Novel bullous pemphigoid models induced by breaking tolerance to autoantigens.
2016 - 2019 Establishment of cicatricial alopecia animal models
2017 - 2019 Dynamics of epithelial stem cells upon wounding
2016 - 2018 Pathogenesis of bullous pemphigoid: a study using class-switched monoclonal antibodies.
2015 - 2018 Treatment of epidermolysis bullosa with revertant keratinocyte-derived iPS cells
2015 - 2017 Prevention of autoantigen depletion for bullous pemphigoid treatment
2015 - 2016 Induction of tolerance to bullous pemphigoid autoantigen by oral administration of antigenic peptides.
2013 - 2016 Elucidating roles of plasmin in blister formation of bullous pemphigoid
2012 - 2016 Production of a novel blistering disease model by regulating expression of collagen XVII
2014 - 2015 Generation of mosaic model of epidermolysis bullosa by inactivation of X chromosome.
2013 - 2014 Modulation of skin microbiota through basememt membrane
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Papers (174):
Kosei Nakamura, Shota Takashima, Takuma Nohara, Mika Watanabe, Ken Natsuga, Hideyuki Ujiie. Development of a nutritionally balanced, melt-in-the-mouth chocolate for patients with epidermolysis bullosa. The Journal of Dermatology. 2023. 50. 12. 1640-1643
Shoko Mai, Kentaro Izumi, Yosuke Mai, Ken Natsuga, Norito Ishii, Daisuke Sawamura, Franziska Schauer, Dimitra Kiritsi, Wataru Nishie, Hideyuki Ujiie. Native Autoantigen Complex Detects Pemphigoid Autoantibodies. JID innovations : skin science from molecules to population health. 2023. 3. 3. 100193-100193
Chiara Levra Levron, Mika Watanabe, Valentina Proserpio, Gabriele Piacenti, Andrea Lauria, Stefan Kaltenbach, Annalaura Tamburrini, Takuma Nohara, Francesca Anselmi, Carlotta Duval, et al. Tissue memory relies on stem cell priming in distal undamaged areas. Nature cell biology. 2023. 25. 5. 740-753
Hideyuki Kosumi, Ken Natsuga, Teruki Yanagi, Hideyuki Ujiie. Systemic Retinoids for Generalized Verrucosis Due to Congenital Immunodeficiency: Case Reports and Review of the Literature. Genes. 2023. 14. 3