Umehara Takashi

ウメハラタカシ | Umehara Takashi

Affiliation and department：
Job title： Senior Scientist
Homepage URL (2)： https://www.bdr.riken.jp/ja/research/labs/umehara-t/index.html , https://www.bdr.riken.jp/en/research/labs/umehara-t/index.html

Research field (3)： Structural biochemistry , Molecular biology , Pharmaceuticals - health and biochemistry

Research keywords (12)： Drug Discovery , Synthetic Biology , Molecular Biology , Nucleosome , Histone , Epigenetics , Gene Expression , Chemical Biology , Chromatin , Structural Biology , Chromosome , Biochemistry

Research theme for competitive and other funds (13)：

2021 - 2024 LSD阻害剤の創製:LSD1阻害剤の創薬展開およびLSD2機能解明の基盤構築
2020 - 2024 がん細胞で頑強に維持される超アセチル化エピゲノムを操作する
2021 - 2023 エピゲノムの修飾密度と分子内相互作用による転写バースト形成の再構成的理解
2020 - 2022 人工細胞膜に封入した後成修飾クロマチン繊維の細胞内導入と遺伝子発現の定量的理解
2016 - 2020 Understanding of regulatory mechanisms of disease-associated epigenome by high-resolution detection of hyperactive chromatin

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Papers (96)：

Akari Miwa, Masatoshi Wakamori, Tetsuro Ariyoshi, Yasushi Okada, Mikako Shirouzu, Takashi Umehara, Koki Kamiya. Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changing lipid composition determined by fluorescence measurements. Scientific reports. 2024. 14. 1. 2852-2852
Masaki Kikuchi, Shohei Takase, Tsuyoshi Konuma, Kota Noritsugu, Saaya Sekine, Takahisa Ikegami, Akihiro Ito, Takashi Umehara. GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 43. e2304103120
Nando D Das, Jen-Chien Chang, Chung-Chau Hon, S Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, et al. Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties. BMC Genomics. 2023. 24. 1. 574-574
Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara. Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nature Communications. 2023. 14. 1. 4103
Nan Liu, Tsuyoshi Konuma, Rajal Sharma, Deyu Wang, Nan Zhao, Lingling Cao, Ying Ju, Di Liu, Shuai Wang, Almudena Bosch, et al. Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Molecular Cell. 2023. 83. 13. 2206-2221

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MISC (25)：

鷲塚健一, 白井文幸, 八代田陽子, 幸瞳, 丹羽英明, 佐藤心, 安倍昌子, 大貫哲男, 眞崎唯, 平間千津子, et al. タンキラーゼ阻害剤の創薬研究(3):新規ジヒドロキナゾリノン誘導体の創出. メディシナルケミストリーシンポジウム講演要旨集. 2019. 37th
甲田泰子, 白井文幸, 水谷アンナ, 八代田陽子, 津村武史, 狩野ゆうこ, 近田翼, 村松由起子, 幸瞳, 丹羽英明, et al. タンキラーゼ阻害剤の創薬研究(1):細胞増殖阻害活性改善を指向した誘導体合成. メディシナルケミストリーシンポジウム講演要旨集. 2019. 37th
白井文幸, 水谷アンナ, 八代田陽子, 津村武史, 狩野ゆうこ, 近田翼, 村松由起子, 幸瞳, 丹羽英明, 佐藤心, et al. タンキラーゼ阻害剤の創薬研究(2):経口投与で抗腫瘍効果を示すスピロインドリノン誘導体RK582の創製. メディシナルケミストリーシンポジウム講演要旨集. 2019. 37th
若森昌聡, 岡部弘基, 岡部弘基, 浦聖恵, 浦聖恵, 船津高志, 瀧ノ上正浩, 瀧ノ上正浩, 梅原崇史, 梅原崇史. 部位特異的アセチル化クロマチンのヌクレオソーム移動・転写速度の経時検出と数理モデル化. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
菊地正樹, 丹羽英明, 梅原崇史. GAS41のYEATSドメインによるアセチル化ヒストンテイルの分子認識機構. 日本薬学会年会要旨集(CD-ROM). 2018. 138th. ROMBUNNO.27PA-am382

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Patents (13)：

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Books (12)：

がんゲノム医療時代の分子腫瘍学: エピジェネティクス (2) ヒストン修飾の異常
病理と臨床 Vol. 40 臨時増刊号 pp. 26-30 2022
エピゲノム創薬によるターゲット探索とその開発・応用動向
疾患原因遺伝子(技術情報協会)pp. 49-59 2022
Academic drug discovery by platforms of structure analysis and in silico design
J. Clin. Exp. Med. 254(8) 566-570 2015
New frontiers of epigenetics researches in pharmaceutical sciences
J. Pharm. Soc. Jpn. 135(1) 1-2 2015
Analysis of gene expression regulation through precise reconstitution of ‘epi-nucleosome’
Seitai No Kagaku (Igaku Shoin Ltd.) 65(5) 462-463 2014

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Education (2)：

1994 - 1999 The University of Tokyo Graduate School of Pharmaceutical Sciences
1990 - 1994 The University of Tokyo Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (8)：

2023 - 現在 RIKEN Senior Scientist
2019 - 2023 RIKEN Team Leader
2013 - 2019 RIKEN Unit Leader
2007 - 2013 RIKEN Senior Scientist
2005 - 2007 RIKEN Research Scientist

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Committee career (2)：

2022 - 現在 Epigenomes Editorial Board Member
2021 - 現在 ACS Bio & Med Chem Au Editorial Advisory Board Member

Awards (1)：

2011 - The Japanese Society for Epigenetics Young Investigator Award

Association Membership(s) (5)：

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , PROTEIN SCIENCE SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR EPIGENETICS , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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