Maita Hiroshi

マイタヒロシ | Maita Hiroshi

Affiliation and department：

Research field (2)： Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (10)： snRNP , Cajal body , pre-mRNA splicing , スプライシング , シグナル伝達 , 分子生物学 , pre-mRNAスプライシング , シグナル転達 , 遺伝子 , 網膜色素変性症

Research theme for competitive and other funds (7)：

2020 - 2023 スプライソソーム形成障害を標的とした低分子薬の探索と解析
2020 - 2022 相分離構造体とプロリン異性化の連携機構の解析と可視化ツールの開発
2016 - 2020 Chemical approach to elucidate the molecular mechanism for the splice site selection
2013 - 2017 Suppression of the splicing mutation based on the molecular mechanism of pre-mRNA splicing fidelity
2011 - 2012 Analysis of the assembly and functional defect of the spliceosome associated with Retinitis pigmentosa

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Papers (31)：

Kenji Tomita, Shinichi Nakagawa, Hiroyoshi Ariga, Hiroshi Maita. BAY61-3606 Alters snRNP Composition and Enhances Usage of Suboptimal Splice Acceptor Site. Biological & pharmaceutical bulletin. 2023. 46. 2. 147-157
Satoshi Sato, Hiroyoshi Ariga, Hiroshi Maita. Development of a Cell-Based Assay Using a Split-Luciferase Reporter for Compound Screening. Biological & pharmaceutical bulletin. 2023. 46. 7. 1010-1014
Osamu Takahashi, Mayuko Tanahashi, Saori Yokoi, Mari Kaneko, Kaori Yanaka, Shinichi Nakagawa, Hiroshi Maita. The cell type-specific ER membrane protein UGS148 is not essential in mice. Genes to cells : devoted to molecular & cellular mechanisms. 2022. 27. 1. 43-60
Hiroshi Maita, Shinichi Nakagawa. What is the switch for coupling transcription and splicing? RNA Polymerase II C-terminal domain phosphorylation, phase separation and beyond. Wiley interdisciplinary reviews. RNA. 2020. 11. 1. e1574
Takanori Matsumaru, Makoto Inai, Kana Ishigami, Toshiki Iwamatsu, Hiroshi Maita, Satoko Otsuguro, Takao Nomura, Akira Matsuda, Satoshi Ichikawa, Masahiro Sakaitani, et al. Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017. 27. 10. 2144-2147

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Professional career (1)：

Work history (4)：

2009/07 - 現在 Hokkaido University Faculty of Pharmaceutical Sciences Lecturer
2010 - 2011 北海道大学薬学研究科(研究院) 講師
2006/03 - 2009/06 Hokkaido University Faculty of Pharmaceutical Sciences Assistant professor
2004/04 - 2006/03 University of Chicago Postdoctoral Fellow

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