Rchr
J-GLOBAL ID：201201076312519844   Update date: Apr. 02, 2024

Koseki Jun

コセキ ジュン | Koseki Jun
Affiliation and department：
National Institute of Advanced Industrial Science and Technology Cellular and Molecular Biotechnology Research Institute

About National Institute of Advanced Industrial Science and Technology Cellular and Molecular Biotechnology Research Institute


Homepage URL  (1)： https://www.nagoya-sysbiol.info/12513125311249612540.html
Research field  (3)： Biophysics ,  Basic physical chemistry ,  Biological, health, and medical informatics
Research keywords  (5)： quantum chemistry ,  molecular dynamics ,  in silico drug design ,  分子設計 ,  Trans-omics Analysis
Research theme for competitive and other funds  (23)：
  • 2022 - 2026 Maternal factors in embryonic development; impact of maternal age
  • 2022 - 2025 NF-κBに依存しない自然免疫誘導メカニズムの解明
  • 2022 - 2025 Development of a theoretical basis for predicting structural and functional changes induced by RNA modifications
  • 2023 - 2024 ポスト抗体医薬を見据えた任意糖鎖に結合するデザイナーレクチン開発法の確立
  • 2019 - 2022 Development of artificial intelligence system to support postoperative chemotherapy
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Papers (84)：
  • Shiki Fujino, Norikatsu Miyoshi, Aya Ito, Rie Hayashi, Masayoshi Yasui, Chu Matsuda, Masayuki Ohue, Masafumi Horie, Shinichi Yachida, Jun Koseki, et al. Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer. Communications Biology. 2023. 6. 1
  • Kazuki Nakai, Hancheng Lin, Shotaro Yamano, Shinya Tanaka, Sho Kitamoto, Hitoshi Saitoh, Kenta Sakuma, Junpei Kurauchi, Eilma Akter, Masamitsu Konno, et al. Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway. Nature Communications. 2023. 14. 1
  • Jun Koseki, Shuto Hayashi, Yasuhiro Kojima, Haruka Hirose, Teppei Shimamura. Topological data analysis of protein structure and inter/intra- molecular interaction changes attributable to amino acid mutations. Computational and Structural Biotechnology Journal. 2023. 21. 2950-2959
  • Shiho Torii, Kwang Su Kim, Jun Koseki, Rigel Suzuki, Shoya Iwanami, Yasuhisa Fujita, Yong Dam Jeong, Jumpei Ito, Hiroyuki Asakura, Mami Nagashima, et al. Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir. PLOS Pathogens. 2023. 19. 3. e1011231-e1011231
  • Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, et al. Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. Cell reports. 2023. 42. 1. 111929-111929
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MISC (30)：
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Books (2)：
  • BIO EX-press
    2016
  • 膵島の再生医療
    診断と治療社 2015
Lectures and oral presentations  (43)：
  • トポロジカルデータ解析を用いた微小構造変化がもたらす構造及び相互作用変化解析
    (第6回理論免疫学ワークショップ 2022)
  • Theoretical prediction of molecular interaction changes caused by microstructural substitutions
    (2021)
  • アミノ酸変異によるタンパク質立体構造変化のトポロジカルデータ解析
    (第15回分子科学討論会 2021)
  • フッ素置換基を有した核酸分子が及ぼすDNA立体構造変化と内部相互作用変化に対する理論解析
    (第42回 日本分子生物学会 2019)
  • p53タンパク質と任意の認識配列の結合構造及び結合親和性予測システムの確立
    (がんと代謝研究会・若手の会 2019)
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Work history (10)：
  • 2024/04 - 現在 National Institute of Advanced Industrial Science and Technology Cellular and Molecular Biotechnology Research Institute
  • 2021/04 - 2024/03 Nagoya University Graduate School of Medicine Systems Biology Associate Professor
  • 2020/01 - 2021/03 GRADUATE SCHOOL OF MEDICINE, NAGOYA UNIVERSITY DIVISION OF SYSTEMS BIOLOGY Designated Associate Professor
  • 2017/04 - 2019/12 Osaka University, Graduate school of Medicine Assistant Professor
  • 2014/04 - 2017/03 Osaka University, Graduate school of Medicine Assistant Professor
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Awards (1)：
  • 2010/10 - Society of Computer Chemistry,Japan Yoshida Prize 2009 Theoretical Analysis of Molecular Orientational Transition in Solid C60
Association Membership(s) (5)：
THE JAPANESE CANCER ASSOCIATION ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  情報計算科学生物学会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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