Research theme for competitive and other funds (7):
2020 - 2023 α-シヌクレインを介したOPRM1遺伝子の転写調節機構の解明
2017 - 2020 Histone modification induced by alpha-synuclein
2014 - 2017 Zeroing in on aberrant membrane trafficking in molecular pathogenesis of Parkinson's disease
2012 - 2016 Early diagnosis and treatment of Parkinson disease dementia
2013 - 2016 内在化αシヌクレインにおけるESCRTを中心とした小胞輸送に関する研究
2011 - 2013 グルコセレブロシダーゼ変異が誘導するα-シヌクレイン細胞毒性に関する研究
2009 - 2010 Cytotoxic effect induced by phosphorylated alpha-synuclein and dopamine
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Papers (122):
Takaaki Nakamura, Naoto Sugeno, Takafumi Hasegawa, Kensho Ikeda, Shun Yoshida, Shun Ishiyama, Kazuki Sato, Atsushi Takeda, Masashi Aoki. Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex. The FEBS journal. 2023
Shun Ishiyama, Takafumi Hasegawa, Naoto Sugeno, Junpei Kobayashi, Shun Yoshida, Yasuo Miki, Koichi Wakabayashi, Mitsunori Fukuda, Yasushi Kawata, Takaaki Nakamura, et al. Sortilin acts as an endocytic receptor for α-synuclein fibril. FASEB journal. 2023. 37. 7. e23017
Naoto Sugeno, Takafumi Hasegawa, Kazuhiro Haginoya, Takafumi Kubota, Kensuke Ikeda, Takaaki Nakamura, Shun Ishiyama, Kazuki Sato, Shun Yoshida, Eriko Koshimizu, et al. Detection of Modified Histones from Oral Mucosa of a Patient with DYT-KMT2B Dystonia. Molecular Syndromology. 2023
Ayane Ohyama-Tamagake, Kimihiko Kaneko, Ryo Itami, Masatsugu Nakano, Yasuhiro Namioka, Rumiko Izumi, Haruka Sato, Hideaki Suzuki, Atsuhito Takeda, Yukiko Yatsuka, et al. Reply to the Letter "Reversible Vasoconstriction Syndrome is a Complication of SARS-CoV-2 Infection/Vaccination Rather Than That of Leigh Syndrome". Internal medicine (Tokyo, Japan). 2023
Naoto Sugeno, Takafumi Hasegawa. Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification. International journal of molecular sciences. 2023. 24. 7
K63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalised alpha-synuclein
(18th International Congress of Parkinson's Disease and Movement Disorders 2014)
Nedd4 E3 ubiquitin ligase facilitates the endosomal targeting of extracellular alpha-synuclein
(The 86th Annual Meeting of the Japanese Biochemical Society 2013)
E3 ubiquitin ligase Nedd4 is a key regulator of the endosomal targeting of alpha-synuclein
(17th International Congress of Parkinson's Disease and Movement Disorders 2012)
Professional career (1):
医学博士
Work history (4):
2021/04 - 現在 Tohoku University
2016/10 - 2021/03 東北大学病院 神経内科 助教
2014/04 - 2016/09 テュービンゲン大学ハーティー脳神経疾患研究所 客員研究員
2011/04 - 2014/04 東北大学病院 神経内科 助教
Awards (1):
2009/06 - すばるの会 論文賞
Association Membership(s) (7):
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, JAPANESE SOCIETY OF CLINICAL NEUROPHYSIOLOGY
, JAPANESE SOCIETY OF NEUROLOGY
, Society for Neuroscience
, 日本パーキンソン病・運動障害疾患学会
, 日本エピジェネティクス研究会
, 日本認知症学会