Shinobu Hirai

ヒライシノブ | Shinobu Hirai

Research field (2)： Neuroscience - general , Neuroscience - general

Research keywords (9)： brain capillary , アストロサイト , Inhibitory neuron , Metabolism , Cognitive function , inflammation , Mental illness , Brain development , Glucose transport

Research theme for competitive and other funds (19)：

2023 - 2026 Evolution of the Cerebral Cortex by Experimental Manipulation Using Cell Cycle Withdrawal Delay
2022 - 2026 Transcriptional repressor RP58 and its mechanism to inhibit brain aging
2023 - 2025 脳毛細血管機能障害と精神疾患発症の因果関係の検証
2023 - 2024 脳内へのグルコース取り込み障害に伴う認知機能低下の発症メカニズムの解明と治療法の開発
2022 - 2024 食物由来グルコースの脳内流通の解明による脳疾患理解の推進

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Papers (18)：

Shinobu Hirai, Atsuhiro Sakuma, Yasuto Kunii, Hiroko Shimbo, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Rika Kojima, Erika Seki, et al. Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease. Journal of psychiatric research. 2023. 163. 74-79
Sayaka Hirai, Hideki Miwa, Hiroko Shimbo, Keisuke Nakajima, Masahiro Kondo, Tomoko Tanaka, Chiaki Ohtaka-Maruyama, Shinobu Hirai, Haruo Okado. The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment. Molecular psychiatry. 2023
Akiyo Natsubori, Shinobu Hirai, Soojin Kwon, Daisuke Ono, Fei Deng, Jinxia Wan, Momoka Miyazawa, Takashi Kojima, Haruo Okado, Akihiro Karashima, et al. Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle. iScience. 2023. 26. 1. 105830-105830
Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, et al. High Sucrose Diets Contribute to Brain Angiopathy with Impaired Glucose Uptake, and Psychosis-related Higher Brain Dysfunctions in Mice. Science Advances. 2021. 7. 46
Hideki Miwa, Ken Kobayashi, Shinobu Hirai, Mitsuhiko Yamada, Masahiko Watanabe, Haruo Okado, Yuchio Yanagawa. GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum. Cerebellum (London, England). 2021

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MISC (5)：

新保裕子, 佐久間敦丈, 平井志伸. 栄養環境により精神疾患様症状を呈したモデルマウスの解析. 実験動物ニュース. 2023. 72. 2
佐久間敦丈, 新保裕子, 平井志伸. 栄養環境依存的な精神疾患モデルマウスの開発を通じた実験動物飼料の理解. LABIO21. 2022. 87
平井志伸. 精神疾患の新たな環境要因を提唱、表現型を発見. 日本神経科学学会会報. 2022. 230. 32-33
Shinobu Hirai. Development of a Novel Mouse Model of Psychiatric Disorders with Decreased Glucose Logistics and Related Findings. 2021. 28. 2. 93-101
平井志伸. グルコース取り込み障害を呈する脳毛細血管障害は精神疾患の指標となりうるか -栄養環境依存性新規モデルマウスの作成,解析を通して-. 日本生物学的精神医学会誌. 2021. 32 巻. 4号. 191-195

Patents (2)：

脳組織の異常を伴う非ヒト動物の作製方法およびその利用
リアノジン受容体活性化剤およびその利用

Lectures and oral presentations (13)：

Effects of voluntary exercise on cognitive dysfunction and anxiety-like behaviors in a mouse model of psychiatric disorders
(The 101st Annual Meeting of The Physiological Society of Japan 2024)
Analysis of astrocytic Glut1 function for the development of a novel therapy for Glut1 deficiency syndrome
(The 101st Annual Meeting of The Physiological Society of Japan 2024)
Abnormal glucose metabolism in mouse models of psychiatric disorders
(2023)
栄養環境依存的な精神疾患モデルマウスの解析を通じた疾患発症メカニズムの探求
(第45回日本分子生物学会年会 2022)
栄養環境依存的な統合失調症モデルマウスの解析から得た、統合失調症『脳内エネルギー不全仮説』の提唱
(第16回日本統合失調症学会 2022)

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Education (3)：

2007 - 2011 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Track
2005 - 2007 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Track
2001 - 2005 Tokyo University of Agriculture and Technology Faculty of Agriculture Department of Applied Biological Scinece

Work history (6)：

2023/04 - 現在同研究グループ、グループリーダー、主席研究員
2022/07 - 現在 Tokyo Metropolitan Institute of Medical Science Brain Metabolic Regulation Group Frontier Laboratory Department of Psychiatry and Behavioral Sciences
2021/04 - 2022/06 Tokyo Metropolitan Institute of Medical Science Sleep Disorders Project senior researcher
2018/04 - 2021/03 Tokyo Metropolitan Institute of Medical Science Neural Development Project senior researcher
2012/04 - 2018/03 Tokyo Metropolitan Institute of Medical Science Neural Development Project Resercher

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Awards (7)：

2024/03 - 東京都医学総合研究所 2023年度理事長表彰
2022/08 - 日本神経精神薬理学会 JSNP Excellent Presentation Award for CINP 2022
2022/06 - 資生堂第15回『資生堂女性研究者サイエンスグラント』
2022/03 - 日本統合失調症学会一般演題賞奨励賞
2019 - 東京都医学総合研究所所内研究発表会(第1部会・第2部会) 優秀賞

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Association Membership(s) (3)：

THE PHYSIOLOGICAL SOCIETY OF JAPAN , THE JAPAN NEUROSCIENCE SOCIETY , The Japanese Society of Neuropsychopharmacology

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