Research field (2)：
Medical biochemistry
, Molecular biology
Research keywords (6)：
Post-Transcriptional Control of Gene Expression
, SMG1
, mRNA decay
, mRNA translation
, Nonsense-mediated mRNA decay
, mRNA surveillance
Research theme for competitive and other funds (23)：
2021 - 2023 がん抗原の発現増強の新手法としてのmRNA監視機構阻害
2020 - 2023 ポスト翻訳終結イベントの調節機構及びその生理病理的意義の解明
2020 - 2023 A pathophysiological significance of receptor-binding factor in aging-associated cerebral cardiovascular disease
2020 - 2023 ゲノム編集法を用いたヒトパピローマウイルスの細胞感染機構の解明
2018 - 2022 Therapeutic Strategy against Renal Aging via Novel Dual Actions of Receptor-binding Molecule
2019 - 2021 Development of basic technology for intractable and rare diseases
2017 - 2020 The pathophysiological significance of receptor-binding cardiovascular protective molecule in aging-associated cardiovascular diseases
2017 - 2020 A study for human papillomavirus (HPV) infection mechanism
2017 - 2019 Development of basic technology for intractable and rare diseases
2017 - 2019 Analysis of the nascent peptide-ribosome complex during amino acid starvation.
2015 - 2018 Post-transcriptional gene expression regulation via mRNA surveillance system
2014 - 2017 A global study for HPV-cell infection mechanism
2013 - 2016 Research on environmental stresses-induced change in nonsense-mediated mRNA decay (NMD) activity and its effect on pathological conditions
2011 - 2015 Gene expression regulation via mRNA surveillance system
2009 - 2015 Regulation of functional machinery of small RNAs
2009 - 2014 Functional machinery for non-coding RNAs
2011 - 2013 異常終止コドン認識複合体の構造機能解析
2010 - 2012 Molecular mechanisms of the polarity-regulating signaling
2009 - 2010 Analysis of mRNP complex using gene knockin in mammalian cells
2008 - 2010 Research on the pathophysiology and treatment of neurological disorders modified by nonsense-mediated mRNA decay (NMD)
2007 - 2008 Analysis of mRNP remodeling during NMD
2006 - 2007 Research on the therapeutic approach targeting an mRNA quality-control in herediatry neurological disorders
1999 - 2001 JNKを活性化するタンパク質リン酸化酵素MSTの生理機能の解析
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Papers (111)：
Keigo Hirota, Akio Yamashita, Eriko Abe, Takahiro Yamaji, Kengo Azushima, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Hiromichi Wakui, Kouichi Tamura. miR-125a-5p/miR-125b-5p contributes to pathological activation of Angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap. The Journal of biological chemistry. 2023. 299. 12. 105478-105478
Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Keigo Hirota, Shunichiro Tsukamoto, Ryutaro Morita, Ryu Kobayashi, et al. Angiotensin II type 1 receptor-associated protein deletion combined with angiotensin II stimulation accelerates the development of diabetic kidney disease in mice on a C57BL/6 strain. Hypertension research : official journal of the Japanese Society of Hypertension. 2023. 47. 1. 55-66
Shunichiro Tsukamoto, Hiromichi Wakui, Tatsuki Uehara, Yuka Shiba, Kengo Azushima, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Keigo Hirota, Shingo Urate, et al. Combination of sacubitril/valsartan and blockade of the PI3K pathway enhanced kidney protection in a mouse model of cardiorenal syndrome. European heart journal open. 2023. 3. 6. oead098
Shunichiro Tsukamoto, Toru Suzuki, Hiromichi Wakui, Tatsuki Uehara, Juri Ichikawa, Hiroshi Okuda, Kotaro Haruhara, Kengo Azushima, Eriko Abe, Shohei Tanaka, et al. Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity. Metabolism: clinical and experimental. 2023. 149. 155706-155706
Hirotatsu Imai, Daisuke Utsumi, Hidetsugu Torihara, Kenzo Takahashi, Hidehito Kuroyanagi, Akio Yamashita. Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification. Nucleic acids research. 2023. 51. 14. e76
1998 - 2001 Yokohama City University Graduate School of Medicine Department of Molecular biology
Professional career (1)：
Ph. D (Yokohama City University graduate school of Medicine)
Work history (3)：
2021/02 - 現在 University of the Ryukyus
2010/04 - 2021/01 Yokohama City University School of Medicine Medical Course Molecular Biology Graduate School of Medicine Degree Program Associate Professor
2007/10 - 2011/03 Japan Science and Technology Agency PREST, RNA and biofunction PREST researcher
