Hamamoto Hiroshi

ハマモトヒロシ | Hamamoto Hiroshi

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://infectiousdiseases-yamagata-u.jp

Research field (3)： Bacteriology , Pharmaceuticals - health and biochemistry , Clinical pharmacy

Research keywords (7)： Host-Microbe interaction , Chemical Biology , Antimicrobials , 細菌感染 , サイトカイン , 自然免疫 , シグナル伝達

Research theme for competitive and other funds (15)：

2023 - 2026 新規抗菌治療薬のメナキノン誘導を伴う殺菌メカニズムの解明
2022 - 2025 歯周病原細菌の9型分泌機構における選択的分泌メカニズムの解明
2022 - 2025 歯周病原細菌などのバクテロイディア綱細菌固有のリポタンパク質輸送機構の解明
2021 - 2024 食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析
2019 - 2022 Mechanism of action analysis of novel antibiotics in host factor contribution to therapeutic efficacy

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Papers (130)：

Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Molecular Editing Enhances Oxidation Resistance of Mena-quinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry - A European Journal. 2023
Yosuke Nakata, Junhao Fu, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. e202301225
Hiroshi Hamamoto, Atsushi Miyashita, Koushirou Kamura, Ryo Horie, Kazuhisa Sekimizu. Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret. Drug discoveries & therapeutics. 2022. 16. 6. 280-285
Suresh Panthee, Hiroshi Hamamoto, Atmika Paudel, Chikara Kaito, Yutaka Suzuki, Kazuhisa Sekimizu. Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220. Heliyon. 2022. 8. 11. e11376
Geberemichal Geberetsadik, Akane Inaizumi, Akihito Nishiyama, Takehiro Yamaguchi, Hiroshi Hamamoto, Suresh Panthee, Aki Tamaru, Manabu Hayatsu, Yusuke Mizutani, Shaban Amina Kaboso, et al. Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs. Antimicrobial agents and chemotherapy. 2022. 66. 9. e0017122

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MISC (60)：

関水和久, 宮下惇嗣, LI Wenyuan, 三上雄大, YU Yidong, 浜本洋. Construction of septic disseminated intravascular coagulation (DIC) model using the silkworm, Bombyx mori. 日本薬学会年会要旨集(Web). 2023. 143rd
浜本洋, 石島早苗, PANTHEE Suresh, 関水和久. Cryptococcus neoformansの病原性因子の網羅的探索. 関東医真菌懇話会プログラム・抄録集. 2022. 41st
浜本洋, 石島早苗, 関水和久. Cryptococcus neoformansの病原性発揮機構の網羅的な理解. 日本医真菌学会雑誌. 2022. 63. Supplement 1
浜本洋. 微生物と宿主の相互作用を利用する新しい作用機序の抗生物質-ライソシンEの治療効果の発揮機構の解明. ファルマシア. 2022. 58. 10. 959-963
浜本洋, PANTHEE Suresh, PAUDEL Atmika, 宮下惇嗣, 関水和久, 関水和久. A novel antibiotic Lysocin E exhibits high therapeutic efficacy through host-microbe interaction. 日本細菌学雑誌(Web). 2022. 77. 1

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Patents (27)：

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Professional career (1)：

Work history (6)：

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Committee career (4)：

Awards (1)：

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