Kiyomitsu Tomomi

キヨミツトモミ | Kiyomitsu Tomomi

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://groups.oist.jp/cddu

Research field (2)： Genetics , Cell biology

Research keywords (7)：デグロン , ゲノム編集 , 光遺伝学 , ダイニン , Symmetric Cell Division , Spindle Positioning , 染色体分配

Research theme for competitive and other funds (8)：

2021 - 2024 分裂期紡錘体の形成・配置制御を司るダイニン複合体/クラスターの機能構造の解明
2017 - 2022 系統的破壊を通じた巨大有糸分裂装置・スピンドルの分子モデル構築
2017 - 2021 Defining the mechanisms of equal-sized cell division using advanced genetic and optogenetic technologies
2016 - 2019 AID-mediated acute protein degradation system in human mitotic cells
2018 - 2018 紡錘体牽引力を生み出すダイニンクラスターの試験管内再構成と構造解析

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Papers (20)：

Ai Kiyomitsu, Toshiya Nishimura, Shiang Jyi Hwang, Satoshi Ansai, Masato T Kanemaki, Minoru Tanaka, Tomomi Kiyomitsu. Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos. Nature communications. 2024. 15. 1. 981-981
Marvin van Toorn, Amy Gooch, Susan Boerner, Tomomi Kiyomitsu. NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles. Current Biology. 2023. 33. 3. 572-580.e2
Tomomi Kiyomitsu, Susan Boerner. The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning. Frontiers in Cell and Developmental Biology. 2021. 9
Kenta Tsuchiya, Hisato Hayashi, Momoko Nishina, Masako Okumura, Yoshikatsu Sato, Masato T. Kanemaki, Gohta Goshima, Tomomi Kiyomitsu. Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes. Current Biology. 2021. 31. 1. 115-127.e3
Tomomi Kiyomitsu. The cortical force-generating machinery: how cortical spindle-pulling forces are generated. Current Opinion in Cell Biology. 2019. in press

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MISC (3)：

Books (4)：

Lectures and oral presentations (5)：

Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
(2018)
Optogenetic assemblies of cortical force-generating complexes during mitosis
(2017)
細胞が等分裂する仕組みとその意義の理解に向けて
(第24回日本バイオイメージング学会 2015)
染色体派生シグナルによる紡錘体配置の制御
(クロマチン動構造若手の会第3回ワークショップ 2015)
対称分裂のための紡錘体配置制御システム
(日本顕微鏡学会分子細胞動態イメージング研究部会 2013)

Professional career (1)：

Work history (8)：

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Awards (2)：

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