Rchr
J-GLOBAL ID：201301022490234440   Update date: Jan. 30, 2024

Otsuka Masato

オオツカ マサト | Otsuka Masato
Affiliation and department：
Setsunan University Faculty of Pharmaceutical Sciences

About Setsunan University Faculty of Pharmaceutical Sciences


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/30243489.ja.html
Research field  (4)： Pharmaceuticals - health and biochemistry ,  Functional biochemistry ,  Structural biochemistry ,  Pharmaceuticals - chemistry and drug development
Research keywords  (28)： MATE ,  Multidrug transporter ,  グルタミン酸 ,  トポロジー ,  organic cation transporter ,  トランスポーター ,  Transporter ,  膜タンパク質 ,  Organic cation transport ,  organic cation ,  多剤耐性 ,  薬物輸送 ,  センサーロドプシン ,  Kidney ,  Organic cation exchange ,  薬物副作用軽減 ,  有機カチオン ,  multidrug ,  輸送体 ,  プロトン交換輸送系 ,  薬物排出 ,  transpoter ,  生化学 ,  大量発現 ,  共役イオン ,  神経科学 ,  Cl^--ATPase ,  D-乳酸
Research theme for competitive and other funds  (19)：
  • 2022 - 2025 多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出
  • 2011 - 2013 The structure and function of new drug excreting transporter MATE in mannmal
  • 2008 - 2010 Molecular design and enzyme inhibition mode using software supported by computer for antitumor active flavin derivatives
  • 2008 - 2010 The structure and function of new drug excreting transporter "MATE" in mannmal.
  • 2006 - 2007 The structure and function analysis of MATE transporter in Mammal.
Show all
Papers (36)：
  • Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote. Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria. Bioorganic & Medicinal Chemistry. 2024. 117606-117606
  • Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote. Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections. Bioorganic & Medicinal Chemistry. 2022. 74. 117042-117042
  • Mitsuhiro Goda, Momo Ikehara, Mako Sakitani, Kana Oda, Keisuke Ishizawa, Masato Otsuka. Involvement of Human Multidrug and Toxic Compound Extrusion (MATE) Transporters in Testosterone Transport. Biological & pharmaceutical bulletin. 2021. 44. 4. 501-506
  • Susumu Shinya, Kentaro Kawai, Atsushi Tarui, Yukiko Karuo, Kazuyuki Sato, Masaya Matsuda, Kazuyuki Kitatani, Naoki Kobayashi, Takeshi Nabe, Masato Otsuka, et al. Importance of the Azole Moiety of Cimetidine Derivatives for the Inhibition of Human Multidrug and Toxin Extrusion Transporter 1 (hMATE1). Chemical & pharmaceutical bulletin. 2021. 69. 9. 905-912
  • Naoki Kobayashi, Shoko Kawasaki-Nishi, Masato Otsuka, Yu Hisano, Akihito Yamaguchi, Tsuyoshi Nishi. MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells. Scientific Reports. 2018. 8. 1. 4969
ｍore...
MISC (6)：
ｍore...
Professional career (1)：
  • 博士(薬学) (岡山大学)
Work history (2)：
  • 2012/04 - 現在 Setsunan University Faculty of Pharmaceutical Sciences
  • 2006/07 - 2012/03 Okayama University
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM