Rchr
J-GLOBAL ID：201301025555991898   Update date: Feb. 11, 2024

Uosaki Hideki

Uosaki Hideki
Affiliation and department：
JMU Division of Regenerative Medicine, Center for Molecular Medicine

About JMU Division of Regenerative Medicine, Center for Molecular Medicine


Job title： Associate Professor
Research field  (3)： Developmental biology ,  Anatomy ,  Cardiology
Research keywords  (9)： 遺伝子治療 ,  ゲノム編集 ,  Regenerative Medicine ,  Stem Cell Biology ,  Transcriptome Analysis ,  Maturation ,  Differentiation ,  Cardiomyocytes ,  Pluripotent Stem Cells
Research theme for competitive and other funds  (24)：
  • 2023 - 2028 次世代医療を目指した再生・細胞医療・遺伝子治療研究開発拠点
  • 2023 - 2026 Elucidation of the mechanism of myocardial energy metabolism regulation by NC compound, a KLF5 inhibitor with a beneficial effect on heart failure.
  • 2022 - 2026 疾患基盤となるサルコメアとミトコンドリア相互制御機構の解明
  • 2022 - 2025 Analysis of myocardial energy metabolism using an ATP visualization model in the progression of hereditary cardiomyopathy
  • 2021 - 2024 哺乳類の出生の異時性に基づく心筋再生機構の解明
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Papers (48)：
  • 徳山 剛士, 魚崎 英毅. 疾患iPS細胞を用いたミトコンドリア病の病態・創薬研究. 生体の科学. 2023. 74. 5. 396-397
  • Tomohiro Hino, Satoshi N Omura, Ryoya Nakagawa, Tomoki Togashi, Satoru N Takeda, Takafumi Hiramoto, Satoshi Tasaka, Hisato Hirano, Takeshi Tokuyama, Hideki Uosaki, et al. An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis. Cell. 2023. 186. 22. 4920-4935
  • Takafumi Hiramoto, Yuji Kashiwakura, Morisada Hayakawa, Nemekhbayar Baatartsogt, Nobuhiko Kamoshita, Tomoyuki Abe, Hiroshi Inaba, Hiroshi Nishimasu, Hideki Uosaki, Yutaka Hanazono, et al. PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells. Communications Medicine. 2023. 3. 1
  • 徳山剛士, 魚崎英毅. iPS細胞を用いたミトコンドリア病の病態解明. 実験医学. 2023. 41. 5. 720-726
  • Chika Watanabe, Hitoshi Osaka, Miyuki Watanabe, Akihiko Miyauchi, Eriko F Jimbo, Takeshi Tokuyama, Hideki Uosaki, Yoshihito Kishita, Yasushi Okazaki, Takanori Onuki, et al. Total and reduced/oxidized forms of coenzyme Q10 in fibroblasts of patients with mitochondrial disease. Molecular genetics and metabolism reports. 2023. 34. 100951-100951
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Patents (3)：
Books (5)：
  • Stem Cells: Latest Advances
    Springer Nature 2021 ISBN:3030770516
  • モデル動物の作製と利用-循環器疾患2021
    エル・アイ・シー 2021
  • Pluripotent Stem-Cell Derived Cardiomyocytes. (In: Yoshida Y. (eds), Methods in Molecular Biology, vol 2320.)
    Humana, New York, NY 2021
  • Cardiac Regeneration using Stem Cells (eds., Fukuda K. & Yuasa S.)
    CRC press 2013
  • Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis (eds., Atwood C.)
    InTech 2011
Lectures and oral presentations  (92)：
  • 多能性幹細胞由来心筋細胞の成熟化と疾患モデルへの挑戦
    (第101回日本生理学会大会 2024)
  • Gene Therapy for Mybpc3 Mutant Cardiomyopathy Models
    (2024)
  • Where are We with the Gene Therapy for Cardiomyopathy?
    (MIS-KOREA 2024 2024)
  • 心筋細胞の成熟を司る転写ネットワーク
    (第46回日本分子生物学会年会 2023)
  • 疾患iPS細胞を用いたBOLA3ミトコンドリア心筋症の病態と新規形態異常Mito-Ballの解明
    (第22回日本ミトコンドリア学会年会 2023)
ｍore...
Education (2)：
  • 2006 - 2011 Kyoto University Graduate School of Medicine
  • 1998 - 2004 Hokkaido University School of Medicine
Work history (4)：
  • 2017/12 - 現在 Jichi Medical University Center for Molecular Medicine, Division of Regenerative Medicine Associate Professor
  • 2016/09 - 2017/11 Jichi Medical University Center for Molecular Medicine, Division of Regenerative Medicine Lecturer
  • 2011/06 - 2016/08 Johns Hopkins University School of Medicine, Division of Cardiology Research Fellow
  • 2011/04 - 2011/05 Kyoto University Center for iPS research and application Research Fellow
Awards (10)：
  • 2018/03 - Hokkaido University School of Medicine Alumni Association Furate Young Investigator Award
  • 2015/12 - BMB Travel Grants for Early Career Researchers in Abroad
  • 2015/11 - American Heart Association BCVS Abstract Travel Grant
  • 2015/05 - Weinstein Conference Travel Award
  • 2014/05 - Weinstein Conference Travel Award
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※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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