Rchr
J-GLOBAL ID：201301027251509430
Update date: Jan. 30, 2024
Yoneda Akihiro
ヨネダ アキヒロ | Yoneda Akihiro
Affiliation and department：
Research field (4)：
Tumor biology
, Immunology
, Laboratory animal science
, Developmental biology
Research keywords (5)：
実験動物学
, 発生生物学
, 遺伝学
, 腫瘍免疫学
, 感染症学
Research theme for competitive and other funds (4)：
- 2022 - 2025 肝転移膵癌における抗癌剤抵抗性獲得機序の解明とその応用
- 2018 - 2021 Targeted inhibition of Tim-3-positive tumor-associated macrophages suppresses tumorigenicity of cancer cells
- 2015 - 2018 Role of tumor-associated macrophages in the acquisition of cancer cell stemness and its application for anti-tumor therapy
- 2006 - 2008 Specific defensive mechanism by alternative splicing variation of bovine virus-resistant Mx gene
Papers (29)：
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Akihiro Yoneda, Yasuaki Tamura. Targeting of collagen-specific chaperone heat shock protein 47 for cancer therapy. Thermal Medicine. 2021. 37. 3. 79-93
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Akihiro Yoneda, Kenjiro Minomi, Yasuaki Tamura. Heat shock protein 47 confers chemoresistance on pancreatic cancer cells by interacting with calreticulin and IRE1α. Cancer science. 2021. 112. 7. 2803-2820
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Yasushi Sato, Akihiro Yoneda, Fumiko Shimizu, Miyuki Nishimura, Rai Shimoyama, Yasuyuki Tashiro, Wataru Kurata, Yoshiro Niitsu. Resolution of fibrosis by siRNA HSP47 in vitamin A-coupled liposomes induces regeneration of chronically injured livers. Journal of gastroenterology and hepatology. 2021. 36. 12. 3418-3428
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Akihiro Yoneda, Kaori Sakai-Sawada, Kenjiro Minomi, Yasuaki Tamura. Heat Shock Protein 47 Maintains Cancer Cell Growth by Inhibiting the Unfolded Protein Response Transducer IRE1α. Molecular cancer research : MCR. 2020. 18. 6. 847-858
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Akihiro Yoneda, Kenjiro Minomi, Yasuaki Tamura. HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1α. Oncogene. 2020. 39. 23. 4519-4537
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MISC (37)：
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田村保明, 米田明弘, 鳥越俊彦. 熱ショックタンパク質47(HSP47)はミオシンIIAとIRE1aとの会合を介して乳がんや膵がんの肺転移を促進する. 日本癌学会学術総会抄録集. 2022. 81回. P-1119
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田村 保明, 米田 明弘. がん細胞の一生(ゆりかごから、成長・独り立ち)を担うHsp47の役割と治療法開発(墓場まで). Thermal Medicine. 2021. 37. Suppl. EL-2
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米田 明弘, 田村 保明. HSP47は小胞体からカルシウムの過剰放出を抑制することで膵癌細胞に抗癌剤耐性能を付与する(HSP47 confers chemoresistance on pancreatic cancer cells by inhibiting release of calcium from the endoplasmic reticulum). 日本癌学会総会記事. 2019. 78回. P-3159
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米田明弘, 田村保明. HSP47によるヒト膵癌細胞の抗がん剤耐性能獲得機序の解明. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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米田明弘, 田村保明. ヒト膵癌細胞の抗癌剤耐性能におけるHSP47の関与. 日本臨床ストレス応答学会大会抄録集. 2019. 14th
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Patents (10)：
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IRE1aの阻害物質を用いたがん転移抑制
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MYH9の阻害物質を用いたがん転移抑制
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ERO1aの阻害物質を用いたがん幹細胞分化誘導およびがん用化学療法の増強
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HSP47の阻害物質を用いた化学療法剤感受性の増強
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HSP47の阻害物質を用いたがん転移抑制
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Books (1)：
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Chaperokine activity of heat shock proteins
Springer International Publishing 2019
Lectures and oral presentations (7)：
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HSP47 maintains cancer cell growth via its inhibitory effect on ER stress sensor IRE1a activity
(AACR Annual Meeting 2017 2017)
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Proof of liver regeneration after resolution of fibrosis by siRNA against HSP47 encapsulated in vitamin A-coupled liposome employing CCl4 mice engineeried with Sox9-Cre(ERT2)/ROSA-YFP genes
(66th Annual Meeting of AASLD 2015)
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Membrane type 1-matrix metalloproteinase-cleaved collagens derived from hepatic stellate cells play crucial role in liver regeneration after partial hepatectomy
(66th Annual Meeting of AASLD 2015)
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A proof of liver regeneration by siRNAgp46 encapsulated in vitamin A-coupled liposome in BDL rats transplanted with GFP-hepatic stem cells
(61th Annual Meeting of AASLD 2010)
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Activated hepatic stellate cells, but not quiescent hepatic stellate cells sustain their survival by PI3K/AKT/FKB signal from collagen secreted by themselves
(60th Annual Meeting of AASLD 2009)
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Professional career (1)：
Awards (4)：
- 2017/11 - 日本臨床ストレス応答学会 若手奨励賞
- 2013 - 公益財団法人国際科学振興財団 研究助成
- 2012/12 - 第20回浜名湖シンポジウム 優秀賞
- 2010 - 公益財団法人伊藤医薬学術交流財団 海外交流助成
Association Membership(s) (5)：
日本実験動物学会
, 日本ゲノム編集学会
, 日本細胞生物学会
, 日本分子生物学会
, 日本癌学会
