Rchr
J-GLOBAL ID：201301039658214475   Update date: Feb. 01, 2024

Natsume Toyoaki

ナツメ トヨアキ | Natsume Toyoaki
Affiliation and department：
Tokyo Metropolitan Institute of Medical Science

About Tokyo Metropolitan Institute of Medical Science


Homepage URL  (1)： https://www.igakuken.or.jp/genome-center
Research field  (3)： Genetics ,  Cell biology ,  Molecular biology
Research keywords  (9)： ゲノム医学 ,  転写 ,  SMC5/6 ,  SMC complex ,  Cell cycle ,  Protein degradation ,  Genome editing ,  Chromosome segregation ,  Chromosome replication
Research theme for competitive and other funds  (4)：
  • 2019 - 2022 ヒトSMC5/6複合体の網羅的アンバイアス解析:オーキシンデグロン法を中心に
  • 2017 - 2018 瞬時に分解すれば見えてくる、MCMヘリカーゼとコヒーシンの共役と多彩な機能
  • 2015 - 2016 Division of labor between MCM2-7 and MCM8-9 helicases in non-canonical DNA replication
  • 2013 - 2014 A new cytogenetic approach toward understanding regeneration of DNA replication fork in human cells: Using genome editing and degron technologies
Papers (30)：
  • Shaun Scaramuzza, Rebecca M. Jones, Martina Muste Sadurni, Alicja Reynolds-Winczura, Divyasree Poovathumkadavil, Abigail Farrell, Toyoaki Natsume, Patricia Rojas, Cyntia Fernandez Cuesta, Masato T. Kanemaki, et al. TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells. Nature Communications. 2023. 14. 1. 5071-5071
  • Eri Koyanagi, Yoko Kakimoto, Tamiko Minamisawa, Fumiya Yoshifuji, Toyoaki Natsume, Atsushi Higashitani, Tomoo Ogi, Antony M. Carr, Masato T. Kanemaki, Yasukazu Daigaku. Global landscape of replicative DNA polymerase usage in the human genome. Nature Communications. 2022. 13. 1. 7221-7221
  • Laura J Grange, John J Reynolds, Farid Ullah, Bertrand Isidor, Robert F Shearer, Xenia Latypova, Ryan M Baxley, Antony W Oliver, Anil Ganesh, Sophie L Cooke, et al. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. Nature communications. 2022. 13. 1. 6664-6664
  • Sundaramoorthy Revathidevi, Kazuyoshi Hosomichi, Toyoaki Natsume, Hirofumi Nakaoka, Naoko T. Fujito, Hisako Akatsuka, Takehito Sato, Arasambattu Kannan Munirajan, Ituro Inoue. AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. International Journal of Molecular Sciences. 2022. 23. 19. 11124-11124
  • Subhendu K Das, Vladislav Kuzin, Donald P Cameron, Suzanne Sanford, Rajiv Kumar Jha, Zuqin Nie, Marta Trullols Rosello, Ronald Holewinski, Thorkell Andresson, Jan Wisniewski, et al. MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome". Molecular cell. 2021
ｍore...
Patents (2)：
Lectures and oral presentations  (21)：
  • DNA topology-dependent regulation of chromosome transactions by human SMC5/6
    (第2回日本遺伝学会春季分科会 2020)
  • ヒトSMC5/6と染色体トランスアクションにおけるDNAトポロジカルストレス:DNAの絡まりと超らせん構造
    (第37回染色体ワークショップ・第18回核ダイナミクス研究会 2019)
  • 第三のSMC複合体、SMC5/6の染色体トランスアクションにおける役割〜DNAトポロジカルストレスの観点から
    (第42回日本分子生物学会年会 2019)
  • Human SMC5/6 and DNA topological stress during chromosome transactions
    (EMBO Workshop: DNA topology and topoisomerases in genome dynamics 2019)
  • Elucidating a fundamental role of human SMC5/6 in chromosome transactions: from the viewpoint of DNA topological stress
    (EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes 2019)
ｍore...
Education (3)：
  • 2003 - 2006 The Graduate University for Advanced Studies (SOKENDAI) School of Life Science Department of Genetics
  • 2001 - 2003 Shinshu University Graduate School of Science and Technology Department of Geosphere and Biosphere Science
  • 1997 - 2001 Shinshu University Faculty of Science Department of Biological Sciences
Professional career (1)：
  • phD (The Graduate University for Advanced Studies (SOKENDAI))
Work history (5)：
  • 2021/09 - 現在 Tokyo Metropolitan Institute of Medical Science
  • 2016/09 - 2021/08 National Institute of Genetics Molecular Cell Engineering Laboratory, Department of Chromosome Science Assistant professor
  • 2013/04 - 2016/08 National Institute of Genetics Molecular Function Laboratory, Center for Frontier Research Postdoctoral fellow
  • 2007/04 - 2013/03 University of Dundee (United Kingdom) Centre for Gene Regulation & Expression, College of Life Sciences Postdoctoral fellow
  • 2006/04 - 2007/03 National Institute of Genetics Division of Mutagenesis, Department of Molecular Genetics Postdoctoral fellow
Awards (5)：
  • 2021/07 - 武田科学振興財団 ライフサイエンス研究助成
  • 2018/03 - 稲盛財団 研究助成
  • 2017/12 - 第一三共生命科学研究振興財団 研究助成
  • 2017/11 - 持田記念医学薬学振興財団 研究助成金
  • 2017/10 - 住友財団 基礎科学研究助成
Association Membership(s) (3)：
JAPAN SOCIETY FOR CELL BIOLOGY ,  THE GENETICS SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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