Hatakeyama Hiroto

ハタケヤマヒロト | Hatakeyama Hiroto

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/70504786.ja.html

Research field (4)： Tumor biology , Pharmacology , Pharmaceuticals - health and biochemistry , Clinical pharmacy

Research keywords (10)：免疫チェックポイント阻害剤 , 抗体医薬 , siRNA , がん治療 , 核酸医薬 , miRNA , 細胞内動態制御 , ドラッグデリバリー , ドラッグデリバリーシステム , 抗腫瘍効果

Research theme for competitive and other funds (10)：

2022 - 2026 腹腔内移行経路による腫瘍微小環境編集と難治性腹膜播種治療への展開
2021 - 2023 免疫チェックポイント阻害剤に対する抗薬物抗体産生のダイバーシティの解明
2019 - 2022 膵臓選択的送達とナノDDSが拓く新規温熱免疫療法による膵癌治療
2017 - 2020 Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor
2018 - 2020 がん細胞および腫瘍微小環境の温熱耐性応答メカニズムの解明

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Papers (84)：

Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi, et al. The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles. Pharmaceutics. 2024. 16. 2
Yi Liu, Miho Suzuoki, Hiroki Tanaka, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita. Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines. Biological & pharmaceutical bulletin. 2024. 47. 3. 698-707
Jessica Anindita, Hiroki Tanaka, Ryotaro Oyama, Shinya Hagiwara, Daiki Shirane, Sakura Taneichi, Yuta Nakai, Kota Tange, Hiroto Hatakeyama, Yu Sakurai, et al. Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds. Pharmaceutics. 2023. 15. 12
Mizuki Doi, Hiroki Tanaka, Takara Ohoto, Naoya Miura, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita. Reactivation of Anticancer Immunity by Resetting Interorgan Crosstalk in Immune-Suppressive Cells with a Nanoparticulated Anti-Inflammatory Drug. Small (Weinheim an der Bergstrasse, Germany). 2023. e2205131
Masaki Gomi, Yu Sakurai, Minami Sato, Hiroki Tanaka, Yumi Miyatake, Koichi Fujiwara, Mizuki Watanabe, Satoshi Shuto, Yuta Nakai, Kota Tange, et al. Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine-Loaded Lipid Nanoparticles. Advanced Healthcare Materials. 2022. 2202528-2202528

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MISC (23)：

金森大誠, 宮崎菜摘, 青木重樹, 伊藤晃成, 樋坂章博, 畠山浩人. 熱ストレス下における熱耐性卵巣癌細胞の代謝シフトの解明. 日本薬学会関東支部大会講演要旨集. 2021. 65th (CD-ROM)
Hiroto Hatakeyama. N/A. 2020. 56. 8. 760-764
原島秀吉, 畠山浩人, 金沢貴憲. 平成維新-平成30年を振り返る- 平成のDDS(siRNA/リポソーム編)を原島先生と共に振り返る MEND(細胞内制御)とPEGジレンマはこうして誕生した. 薬剤学: 生命とくすり. 2020. 80. 1. 13-23
Hiroto Hatakeyama. N/A. 2019. 79. 2. 80-83
N/A. 2017. 32. 4. 323-329

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Patents (1)：

細胞内動態を改善したカチオン性脂質

Books (1)：

Cancer Drug Delivery Systems Based on the Tumor Microenvironment
Springer 2019 ISBN:9784431568803

Professional career (1)：

博士(薬学) (北海道大学)

Work history (8)：

2022/04 - 現在 Chiba University Graduate School of Pharmaceutical Sciences Professor
2019/10 - 2022/03 Chiba University Graduate School of Pharmaceutical Sciences Associate Professor
2016/01 - 2019/09 Chiba University, Faculty of Pharmaceutical Sciences Laboratory of Clinical Pharmacology and Pharmacometrics Assistant Professor
2013/10 - 2016/01 The University of Texas MD Anderson Cancer Center Department of Gynecologic Oncology and Reproductive Medicine Postdoctoral Fellow
2013/10 - 2015/09 日本学術振興会海外特別研究員

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Committee career (5)：

2023/07 - 現在日本DDS学会評議員
2023/06 - 現在日本毒性学会評議員
2022/11 - 現在日本薬物動態学会 DDS DIS委員
2020/04 - 現在日本薬剤学会代議員
2017/02 - 2022/11 日本薬物動態学会 PMx-1 DIS委員

Awards (14)：

2020/05 - 日本薬剤学会 2020年度奨励賞
2019/07 - 医療薬学フォーラム2019/第27回クリニカルファーマシーシンポジウム優秀ポスター賞抗PD-1抗体と抗PD-L1抗体は同等か-マウスモデルを用いた動態と薬効の比較解析
2018/07 - KJYSP Chair's Selection Award
2017/07 - The Japan Society of Drug Delivery System The Japan Society of Drug Delivery System Young Investigator's award
2017/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists Development of a novel liposomal DDS by manipulating pharmacokinetics and intracellular trafficking for drug therapy and nucleic acid medicine

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Association Membership(s) (8)：

日本がん免疫学会 , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , American Association for Cancer Research , THE JAPANESE CANCER ASSOCIATION , THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本毒性学会

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