Ohishi Tomokazu

オオイシトモカヅ | Ohishi Tomokazu

Affiliation and department：
Job title： Senior Researcher
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/50442546.ja.html

Research field (4)： Tumor biology , Pharmaceuticals - chemistry and drug development , Tumor diagnostics and therapeutics , Laboratory animal science

Research keywords (14)： Phospholipid remodeling , bacteriology , microbiology , Monoclonal antibody , Cancer metastasis , Tea , PARP , Poly(ADP-ribosyl)ation , Tankyrase , Cancer , Tmour , Molecular targeted therapy , Chemical biology , Tumor-stromal cell interactions

Research theme for competitive and other funds (11)：

2022 - 2025 大腸がん肝転移を規定する間質由来因子PAI-1を標的とした治療戦略の確立
2023 - 2024 冬虫夏草菌類二次代謝産物とマウス腫瘍モデルを用いた新規創薬シードの探索
2021 - 2024 難治性がんを標的とした先端的がん特異的抗体創製基盤技術開発とその医療応用(研究開発代表者:加藤幸成)
2022 - 2023 リゾリン脂質アシル基転移酵素LPCAT1によるがんの細胞膜リン脂質リモデリングの意義の解明
2021 - 2022 肝臓間質細胞由来因子を標的とした大腸がん肝転移の治療戦略

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Papers (96)：

Mika K. Kaneko, Hiroyuki Suzuki, Yukinari Kato. Establishment of a Novel Cancer-Specific Anti-HER2 Monoclonal Antibody H₂Mab-250/H₂CasMab-2 for Breast Cancers. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 2024
Takao Arimori, Emiko Mihara, Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K. Kaneko, Junichi Takagi, Yukinari Kato. Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies. Structure. 2024
Mika K. Kaneko, Hiroyuki Suzuki, Tomokazu Ohishi, Takuro Nakamura, Tomohiro Tanaka, Yukinari Kato. A Cancer-Specific Monoclonal Antibody against HER2 Exerts Antitumor Activities in Human Breast Cancer Xenograft Models. International Journal of Molecular Sciences. 2024. 25. 1
Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato. A Cancer-Specific Monoclonal Antibody against Podocalyxin Exerted Antitumor Activities in Pancreatic Cancer Xenografts. International journal of molecular sciences. 2023. 25. 1
Daisuke Tatsuda, Masahide Amemiya, Chisato Nosaka, Ryuichi Sawa, Hideyuki Muramatsu, Masayuki Igarashi, Junjiro Yoshida, Tomokazu Ohishi, Manabu Kawada. Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells. The Journal of antibiotics. 2023

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MISC (86)：

吉田潤次郎, 大石智一, 川田学. がんエネルギー代謝を標的とした創薬-Targeting the cancer energy metabolism using inhibitors of the metabolic enzymes. 腫瘍内科 = Clinical oncology / 腫瘍内科編集委員会編. 2023. 31. 1. 102-108
Asano Teizo, Ohishi Tomokazu, Suzuki Hiroyuki, Kawada Manabu, Kaneko Mika K., Kato Yukinari. Antitumor activity of a novel anti-HER3 monoclonal antibody in mouse xenografts of colorectal cancer. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-O-056
Takei Junko, K. Kaneko Mika, Ohishi Tomokazu, Asano Teizo, Kawada Manabu, Harada Hiroyuki, Kato Yukinari. Development of a monoclonal antibody for CD44-expressing oral cancers. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 2-O-D1-4
大石智一, 吉田潤次郎, 川田学. The existing state of drug development targetting the tumor-stromal cell interactions. 実験医学. 2021. 39. 12
大石智一, 川田学. Involvement of the fibrinolytic system regulator in the liver metastasis of colorectal cancer. 日本がん転移学会学術集会・総会プログラム抄録集. 2021. 30th

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Books (5)：

CLINICAL ONCOLOGY
2023
実験医学増刊(Vol.39 No.12)がん微小環境に1細胞レベルで挑む
羊土社 2021
微生物と免疫
建帛社 2020
がんの分子標的治療 = Molecular target therapy of cancer
南山堂 2008 ISBN:9784525420413
細胞 The CELL 2007年10月号
ニューサイエンス社 2007

Lectures and oral presentations (7)：

冬虫夏草類培養液を用いた制がん剤in vivoスクリーニング系の構築と探索研究
(岩手生物工学研究センター研究セミナー 2023)
大腸がん肝転移におけるがん間質相互作用の役割とその制御
(第32回がん転移学会学術集会・総会シンポジウム「がん転移に克つためのバイオ医薬開発技術の最前線」 2023)
今こそ正しく知りたい!!お茶の成分と健康機能
(NPO法人中国茶文化協会主催オープンセミナー 2023)
お茶の健康機能の新たな可能性~新型コロナ、がん、生活習慣病〜
(今知りたい!!Withコロナ時代におけるお茶のちから公開シンポジウム(静岡県立大学) 2023)
ポリフェノール類の生体機能の新たな可能性
(日本カテキン学会特別講演II 2022)

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Education (1)：

2002 - 2006 The University of Tokyo Graduate School of Medicine

Professional career (1)：

博士(医学) (東京大学)

Work history (4)：

2022/04 - 現在 Institute of Microbial Chemistry(BIKAKEN), Microbial Chemistry Research Foundation Laboratory of Oncology, Numazu brunch
2015/04 - 2022/03 Institute of Microbial Chemistry(BIKAKEN), Microbial Chemistry Research Foundation Numazu branch
2014/04 - 2015/03 Tokyo Metropolitan Institute of Medical Science
2006/04 - 2014/03 Japanese Foundation for Cancer Research

Committee career (3)：

2018/04 - 現在 International Symposium on Cancer Chemotherapy Committee member
2017/04 - 現在 Japanese Association for Molecular Target Therapy of Cancer Councilor
2022/01 - 2023/01 第32回新薬創製談話会事務局

Awards (7)：

2021/05 - The Japanese Association for Molecular Target Therapy of Cancer Excellent Presentation Award
2020/01 - 第20回関東ホルモンと癌研究会幹事特別賞
2017/03 - Cosmo Bio Co., LTD. Cosmo Bio Award
2016/12 - The Japanese Society of Clinical Pharmacology and Therapeutics Excellent Presentation Award
2016/06 - The Japanese Association for Molecular Target Therapy of Cancer Research Encouragement Award

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Association Membership(s) (5)：

The Japanese Society of Clinical Pharmacology and Therapeutics , The Japanese Association for Metastasis Research , International Symposium on Cancer Chemotherapy , The Japanese Association for Molecular Target Therapy of Cancer , Japanese Cancer Association

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