Tokunaga Shinji

トクナガシンジ | Tokunaga Shinji

Affiliation and department：

Research field (5)： Pharmaceuticals - chemistry and drug development , Biological, health, and medical informatics , Molecular biology , Cell biology , Neuroscience - general

Research keywords (8)：脳卒中 , ミトコンドリア , 創薬研究 , ケミカルバイオロジー , ミエリン形成 , NAD metabolism , axonal degeneration , neuroscience

Research theme for competitive and other funds (2)：

2023 - 2026 ヒトシュワン細胞の分化制御機構解明に資する培養技術の確立
2015 - 2017 新規軸索保護化合物を用いた軸索維持・破壊機構の解明

Papers (6)：

Shuji Wakatsuki, Shinji Tokunaga, Megumi Shibata, Toshiyuki Araki. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. JOURNAL OF CELL BIOLOGY. 2017. 216. 2. 477-493
Fuminori Saitoh, Shuji Wakatsuki, Shinji Tokunaga, Hiroki Fujieda, Toshiyuki Araki. Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation. SCIENTIFIC REPORTS. 2016. 6. 29856
Shohei Oie, Kazuya Matsuzaki, Wataru Yokoyama, Shinji Tokunaga, Tsuyoshi Waku, Song-Iee Han, Naoya Iwasaki, Aya Mikogai, Kayoko Yasuzawa-Tanaka, Hiroyuki Kishimoto, et al. Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity. CELL REPORTS. 2014. 7. 3. 807-820
Kazuya Togashi, Shuji Wakatsuki, Akiko Furuno, Shinji Tokunaga, Yoshitaka Nagai, Toshiyuki Araki. Na+/H+ Exchangers Induce Autophagy in Neurons and Inhibit Polyglutamine-Induced Aggregate Formation. PLOS ONE. 2013. 8. 11. e81313
J. Y. Park, S. Y. Jang, Y. K. Shin, H. Koh, D. J. Suh, T. Shinji, T. Araki, H. T. Park. MITOCHONDRIAL SWELLING AND MICROTUBULE DEPOLYMERIZATION ARE ASSOCIATED WITH ENERGY DEPLETION IN AXON DEGENERATION. NEUROSCIENCE. 2013. 238. 258-269

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MISC (1)：

德永慎治. NAD合成経路改変によるミトコンドリア機能障害からの神経保護. 実験医学. 2012. 30. 9. 1418-1422

Lectures and oral presentations (1)：

軸索変性過程におけるミトコンドリア異常からの神経保護的治療戦略
(第85回日本生化学会大会 2012)

Education (3)：

2007 - 2012 Waseda University
2004 - 2007 Waseda University School of Science and Engineering
2003 - 2004 Waseda University School of Science and Engineering

Professional career (1)：

博士(理学) (早稲田大学院)

Work history (5)：

2023/08 - 現在 National Center of Neurology and Psychiatry
2020/10 - 2023/07 National Center of Neurology and Psychiatry PNS Research
2018/08 - 2020/09 Jiksak Bioengineering Co. COO
2017/04 - 2018/07 ラクオリア創薬株式会社創薬研究部門生物研究部リサーチャー
2012/07 - 2017/03 国立精神・神経医療研究センター神経研究所非常勤研究員

Awards (1)：

2012 - 新学術領域「脳内環境」 Travel Award(若手研究者海外発表渡航助成)

Association Membership(s) (1)：

Society for Neuroscience

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