Rchr
J-GLOBAL ID:201301047811390973   Update date: Jan. 22, 2024

Kato Taisuke

カトウ タイスケ | Kato Taisuke
Affiliation and department:
Job title: Associate professor
Research field  (2): Molecular biology ,  Neuroscience - general
Research keywords  (6): Polyglutamine diseases ,  Genome editing ,  Small vessel disease ,  包括脳ネットワーク ,  amyotrophic lateral sclerosis ,  CARASIL
Research theme for competitive and other funds  (9):
  • 2022 - 2025 脳小血管の細胞外基質の摂動を起こす細胞群の同定と、その制御機構の解読
  • 2022 - 2025 脳小血管線維化促進細胞の同定による脳小血管老化の解明
  • 2021 - 2024 細胞老化から解く、真のTDP-43プロテイノパチー分子機構への挑戦
  • 2019 - 2022 Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.
  • 2018 - 2021 Elucidation of the mechanism of gain-of-toxic function by abnormal subcellular localization of cerebral small vessel disease-related mutant TREX1
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Papers (50):
  • Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno. TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models. Acta neuropathologica. 2023
  • Masahiro Uemura, Sho Kitahara, Taisuke Kato, Hiroaki Nozaki, Shoichiro Ando, Tomohiko Ishihara, Osamu Onodera. Inappropriate interpretation of non-pathogenic HTRA1 variant as pathogenic. Annals of clinical and translational neurology. 2023. 10. 7. 1261-1262
  • Yutaka Otsu, Masahiro Hatakeyama, Takeshi Kanayama, Natsuki Akiyama, Itaru Ninomiya, Kaoru Omae, Taisuke Kato, Osamu Onodera, Masanori Fukushima, Takayoshi Shimohata, et al. Oxygen-Glucose Deprived Peripheral Blood Mononuclear Cells Protect Against Ischemic Stroke. Neurotherapeutics. 2023
  • Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Ramil Gabdulkhaev, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, et al. Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 23. e2214652120
  • 北原 匠, 加藤 泰介, 小野寺 理. 【神経核内封入体病・白質脳症】HTRA1遺伝子変異に関連する脳小血管病. 脳神経内科. 2022. 97. 1. 71-73
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MISC (35):
  • 坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, et al. TDP-43 differentially propagates to induce degeneration in the motor circuit. Dementia Japan. 2023. 37. 4
  • 森秀樹, 坪口晋太朗, 佐藤時春, 中村由香, 加藤泰介, 須貝章弘, 小野寺理, 上野将紀. TDP-43変異型により異なる病態進展特性の解析. Dementia Japan. 2023. 37. 4
  • 加藤泰介, 眞鍋理一郎, 五十嵐博中, 亀谷富由樹, 齊藤聡, 畠野雄也, 安藤昭一朗, 福永雅喜, 佐藤俊哉, 齋藤理恵, et al. 遺伝性脳小血管病モデルから見えてきたmatrisomeの破綻と治療法の展望. Dementia Japan. 2022. 36. 4
  • 加藤泰介, 眞鍋理一郎, 五十嵐博中, 亀谷富由樹, 齊藤聡, 畠野雄也, 安藤昭一朗, 福永雅喜, 佐藤俊哉, 齋藤理恵, et al. Matrisomeの擾乱から見た脳小血管病の分子病態と治療法への展望. Dementia Japan. 2022. 36. 4
  • TSUBOGUCHI Shintaro, NAKAMURA Yuka, ISHIHARA Tomohiko, KATO Taisuke, KOYAMA Akihide, SATO Tokiharu, YOSHIDA Yutaka, UENO Masaki, ONODERA Osamu. Spreading of TDP-43 via direct corticospinal connections in mouse models. 日本神経学会学術大会プログラム・抄録集. 2020. 61st
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Lectures and oral presentations  (4):
  • Gene therapy for DRPLA model mice by AAV-delivered CRISPR / Cas9
    (Genome Engineering: From Mechanisms to Therapies, Keystone Symposia Conference 2019)
  • Therapeutic strategy based on genome editing by CRISPR/Cas9 for polyglutamine disease using DRPLA model
    (Advances in Neurodegenerative Disease Research and Therapy. Keystone Symposia Conference. 2018)
  • Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels.
    (2017)
  • Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels.
    (Neuroscience2017 2017)
Education (3):
  • 2006 - 2010 Niigata University Graduate School of Medical and Dental Sciences
  • 2004 - 2006 Niigata University Graduate School of Medical and Dental Sciences
  • 2000 - 2004 Niigata University Faculty of Agriculture Department of Applied Biological Chemistry
Professional career (1):
  • 医学博士 (Ph.D.) (新潟大学)
Work history (3):
  • 2022/04 - 現在 新潟大学脳研究所 分子神経疾患資源解析学分野 准教授
  • 2017/04 - 2022/03 Niigata University Brain Research Institute
  • 2013/10 - 2016/03 Niigata University Brain Research Institute
Awards (1):
  • 2014 - 包括型脳科学研究推進支援ネットワーク 夏のワークショップ若手優秀発表賞受賞 筋萎縮性側索硬化症運動神経細胞におけるTDP-43 mRNAの細胞内局在解析
Association Membership(s) (3):
THE JAPAN NEUROSCIENCE SOCIETY ,  Japanese Society for Neurochemistry ,  Society for Neuroscience
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