Research theme for competitive and other funds (36)：
2022 - 2025 Elucidation of the mechanism of action of Siglec-15 antibody drugs in the treatment of secondary osteoporosis during growth and development
2021 - 2025 Anlysis of the RANKL-Siglec-15 signal molecular mechanism for alveolar bone regeneration
2020 - 2023 Elucidation of unknown network mechanism of osteoprotegerin in bone, cardiovascular and digestive system
2020 - 2023 幹細胞の分化を司る組織常在型M3マクロファージとそのマスター転写因子の同定
2019 - 2022 Development of new therapeutic agents for bone and periodontal diseases based on the bone metabolism-uncoupling mechanisms
2019 - 2022 Development of a potential new marker of periodontal disease status based on serum IL-1 receptor accessory protein .
2018 - 2021 Functional role of cell migration factor LRP1 in periodontal tissue repair
2018 - 2021 Development of the new periodontal treatments based on the regulation of sclerostin secretion
2017 - 2020 Analysis and clinical application of new function of osteoprotegerin as anti-aging factor
2017 - 2020 Development of Simultaneous Regeneration Treatment for Tooth and Periodontal Tissue -Possibility of Tooth Germ Transplantation-
2016 - 2019 Applied research of periodontal disease therapeutics using osteogenic sugnal from osteoclasts
2015 - 2018 Clofibrate produce IL-1Ra and inhibit the experimental periodontitis
2015 - 2018 Attempt of bone regeneration by RANK peptide using alveolar bone resorption model
2015 - 2018 Functional roles of RhoT1 on repair of periodontal tissue
2014 - 2017 Effects of periodontal disease via serum amyloid A on aging on the mechanism of exacerbation of arteriosclerosis
2013 - 2016 Osteoclast-derived factors for inhibiting sclerostin expression is a bone coupling factor.
2012 - 2015 Production of the inflammatory periodontal disease model by the enhanced MAPK signaling
2012 - 2015 Regulations of bone metabolism by bovine- and neutrophil-derived lactoferrin
2012 - 2015 Analysis of bone remodeling mechanism between osteoblasts and osteoclasts for the alveolar bone regeneration
2013 - 2014 骨代謝共役を担うWntシグナルの解明
2011 - 2013 Analysis of the condition stress on the periodontal disease
2010 - 2011 The produced newly inflammatory periodontal disease model and evaluation of the therapeutic drug
2009 - 2011 Basic research on development of new treatment of alveolar bone regeneration
2009 - 2010 LPSシグナルを用いた口腔粘膜疾患モデルの開発
2008 - 2010 Microenvironment of stem cells in bone formation
2008 - 2010 Analysis of molecular mechanism of carbon nanotube regulating bone metabolism
2008 - 2009 Using bone resorption-related gene-modified mice, analysis of periodontitis model and development of drugs
2006 - 2008 Elucidation of the mechanism of enhancement of ectopic bone formation in osteopetrotic mice.
2006 - 2007 歯周組織再生を目指したCaチャンネル阻害剤の骨吸収と骨形成作用の解析
2006 - 2007 転写因子AP-1やNF-κBと協奏的に働く破骨細胞の分化因子のクローニング
2006 - 2007 The relationship between cell proliferation and RANKL-induced osteoclastogenesis
2004 - 2005 Ara-c(白血病薬剤)の骨代謝に及ぼす影響および骨再生についての研究
2004 - 2005 The roll of soluble interleukin-1 receptor type 2 for periodontal tissue
2003 - 2005 The working mechanism of bone resorption inhibitory protein induced by osteoclasts
2002 - 2003 The effects of the role of cytokine stimulated capsular polysaccharide Actinobacillus actinomycetemcomitans in human gingival fibroblast and monocyte.
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Papers (67)：
Keigo Nakamura, Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Mai Matsushita, Hisataka Yasuda, Yuichi Ishihara, Nobuo Yoshinari, Nobuyuki Udagawa. Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation. Journal of Periodontal Research. 2023. 58. 4. 769-779
Toru Hiraga, Kanji Horibe, Masanori Koide, Teruhito Yamashita, Yasuhiro Kobayashi. Sclerostin blockade promotes bone metastases of Wnt-responsive breast cancer cells. Cancer science. 2023. 114. 6. 2460-2470
宇田川 信之, 中村 美どり, 小出 雅則, 小林 泰浩. 糖鎖認識分子による炎症制御と組織再生 Siglec-15は破骨細胞分化・骨吸収機能および骨芽細胞分化に重要な役割を果たす(Siglec-15 plays an important role in osteoclast differentiation, function of bone resorption and osteoblast differentiation). Journal of Oral Biosciences Supplement. 2022. 2022. 88-88
何 治鋒, 溝口 利英, 平賀 徹, 中道 裕子, 山下 照仁, 小出 雅則, 宇田川 信之, 小林 泰浩. マクロファージはLepR陽性細胞を活性化し骨再生を促進する(Macrophages promote bone regeneration through the activation of LepR(+) cells). Journal of Oral Biosciences Supplement. 2022. 2022. 166-166
中村 美どり, 宇田川 信之, 小出 雅則, 上原 俊介, 山下 照仁, 小林 泰浩. シアル酸受容体タンパク質Siglec-15中和抗体の破骨細胞と骨芽細胞に対する作用(Effects of sialic acid receptor protein Siglec-15 neutralizing antibody on osteoclasts and osteoblasts). Journal of Oral Biosciences Supplement. 2022. 2022. 359-359
