Sengoku Toru

センゴクトオル | Sengoku Toru

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60576312.ja.html

Research field (1)： Structural biochemistry

Research keywords (6)： Structural Biology , Epigenetics , Transcription , 環状ペプチド , RNA , Drug Design

Research theme for competitive and other funds (11)：

2020 - 2025 Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products
2021 - 2024 Structural elucidation of the multi-subunit interactions that establish the transcriptional unity mechanism
2021 - 2024 Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions
2021 - 2024 トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明
2020 - 2022 Mechanisms that establish, maintain, and dysregulate histone methylation states

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Papers (36)：

Alexander A Vinogradov, Yue Zhang, Keisuke Hamada, Shunsuke Kobayashi, Kazuhiro Ogata, Toru Sengoku, Yuki Goto, Hiroaki Suga. A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. Journal of the American Chemical Society. 2024. 146. 12. 8058-8070
Shuhei Onishi, Kotone Uchiyama, Ko Sato, Chikako Okada, Shunsuke Kobayashi, Keisuke Hamada, Tomohiro Nishizawa, Osamu Nureki, Kazuhiro Ogata, Toru Sengoku. Structure of the human Bre1 complex bound to the nucleosome. Nature communications. 2024. 15. 1. 2580-2580
Yuchen Zhang, Keisuke Hamada, Masayuki Satake, Toru Sengoku, Yuki Goto, Hiroaki Suga. Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases. Journal of the American Chemical Society. 2023
Sachiko Ohori, Akihiko Miyauchi, Hitoshi Osaka, Charles Marques Lourenco, Naohiro Arakaki, Toru Sengoku, Kazuhiro Ogata, Rachel Sayuri Honjo, Chong Ae Kim, Satomi Mitsuhashi, et al. Biallelic structural variations withinFGF12detected by long-read sequencing in epilepsy. Life Science Alliance. 2023. 6. 8. e202302025-e202302025
Toru Sengoku, Masaaki Shiina, Kae Suzuki, Keisuke Hamada, Ko Sato, Akiko Uchiyama, Shunsuke Kobayashi, Asako Oguni, Hayato Itaya, Kota Kasahara, et al. Structural basis of transcription regulation by CNC family transcription factor, Nrf2. Nucleic Acids Research. 2022. 50. 21. 12543-12557

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MISC (11)：

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Works (29)：

Nrf2-MafG heterodimer bound with CsMBE1
Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Okada, C., Baba, S., Ohta, T., Motohashi, H., Yamamoto, M., Ogata, K.
Nrf2-MafG heterodimer bound with CsMBE2
Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Okada, C., Baba, S., Ohta, T., Motohashi, H., Yamamoto, M., Ogata, K.
Nrf2 (A510Y)-MafG heterodimer bound with CsMBE2
Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Okada, C., Baba, S., Ohta, T., Motohashi, H., Yamamoto, M., Ogata, K.
Crystal structure of TNIK-thiopeptide TP1 complex
Hamada, K., Vinogradov, A.A., Zhang, Y., Chang, J.S., Nishimura, H., Goto, Y., Onaka, H., Suga, H., Ogata, K., Sengoku, T.
Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex
Hamada, K., Vinogradov, A.A., Zhang, Y., Chang, J.S., Nishimura, H., Goto, Y., Onaka, H., Suga, H., Ogata, K., Sengoku, T.

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Professional career (1)：

Work history (1)：

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